Preassociation of STAT1 with STAT2 and STAT3 in Separate Signalling Complexes Prior to Cytokine …
LF Stancato, M David, C Carter-Su, AC Larner, WB … - J. Leukoc. Biol, 2004 - dx.doi.org
... Molecular Biology, Inc. Preassociation of STAT1 with STAT2 and STAT3 in Separate
Signalling Complexes Prior to Cytokine Stimulation. ...
Cited by 29 - Web Search - jbc.org - www-biology.ucsd.edu - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

STAT3 complements defects in an interferon-resistant cell line: Evidence for an essential role for … - Full text - MIT Libraries
CH Yang, A Murti, LM Pfeffer - Cell, 1998 - dx.doi.org
... The type I interferons (IFN / ) promote the DNA-binding activity of the
transcription factors STAT1, STAT2, and STAT3. Although ...
Cited by 44 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Application of Genomic DNA Affinity Chromatography Identifies Multiple Interferon--regulated Stat2 … - Full text - MIT Libraries
JJ Ghislain, EN Fish - Mol. Cell. Biol, 2002 - jbc.org
... transduction is mediated by the phosphorylation-activation of the signal transducer
and activator of transcription (STAT) proteins Stat1, Stat2, and Stat3. ...
Cited by 23 - Web Search - ncbi.nlm.nih.gov

Cloning of a new type II cytokine receptor activating signal transducer and activator of … - Full text - MIT Libraries
L Dumoutier, D Lejeune, S Hor, H Fickenscher, JC … - Biochem. J, 2003 - biochemj.org
... transcription (STAT) 1, STAT2 and STAT3. ... of LICR2, activated STAT1, STAT2, STAT3
and STAT5 upon IL-10 stimulation, in a JAK1- dependent manner. ...
Cited by 9 - View as HTML - Web Search - biochemj.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Reflections on STAT3, STAT5, and STAT6 as fat STATs - Full text - MIT Libraries
JE Darnell Jr - Proc. Natl. Acad. Sci. USA, 1996 - pnas.org
... DNA- binding complexes containing, individually, STAT3, STAT5, or STAT6;
STAT1, STAT2, and STAT4 were not detectably activated. ...
Cited by 26 - Web Search - pubmedcentral.nih.gov - dx.doi.org - intl.pnas.org - all 7 versions »

Urokinase Induces Activation and Formation of Stat 4 and Stat 1-Stat 2 Complexes in Human Vascular … - Full text - MIT Libraries
I Dumler, A Kopmann, K Wagner, OA Mayboroda, U … - J Biol Chem, 1999 - jbc.org
... Besides formation of homodimers, activated Stat1 can form heterodimers in
combination with Stat3 or Stat2. The Stat1-Stat3 heterodimer ...
Cited by 21 - Web Search - dx.doi.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

Interleukin-10 inhibits expression of both interferon-and interferon-induced genes by suppressing … - Full text - MIT Libraries
S Ito, P Ansari, M Sakatsume, H Dickensheets, N … - Blood, 1999 - bloodjournal.org
... 15 IFN activates Tyk2, Jak1, STAT1, STAT2, STAT3, and STAT5. ... 35 IFN can activate
several STATs, including STAT1, STAT2, STAT3, STAT4, and STAT5. ...
Cited by 29 - Web Search

Hendra virus V protein inhibits interferon signaling by preventing STAT1 and STAT2 nuclear … - Full text - MIT Libraries
JJ Rodriguez, LF Wang, CM Horvath - J. Virol, 2003 - pubmedcentral.nih.gov
... were immunoprecipitated with FLAG epitope-specific antibody, and immune complexes
were processed for immunoblotting with antiserum for STAT1, STAT2, or STAT3. ...
Cited by 12 - Web Search - dx.doi.org - jvi.asm.org - ncbi.nlm.nih.gov - all 7 versions »

Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in … - Full text - MIT Libraries
JD Farrar, JD Smith, TL Murphy, S Leung, GR Stark, … - Nat. Immunol, 2000 - nature.com
... 24. Leung, S., Qureshi, SA, Kerr, IM, Darnell, JE & Stark, GR Role of STAT2 in the ...
Direct association of STAT3 with the IFN- R-1 chain of the human type I ...
Cited by 65 - Web Search - nature.com - uiowa.edu - ncbi.nlm.nih.gov

The Proximal Tyrosines of the Cytoplasmic Domain of the beta Chain of the Type I Interferon Receptor … - Full text - MIT Libraries
OW Nadeau, P Domanski, A Usacheva, S Uddin, LC … - J Biol Chem, 1999 - dx.doi.org
... L /IFNAR2) of the type I interferon receptor (IFN-R) in the activation of signal
transducer and activator of transcription (Stat) 1, Stat2, and Stat3 has not ...
Cited by 27 - Web Search - jbc.org - jbc.org - ncbi.nlm.nih.gov - all 5 versions »

Tyrosine-Phosphorylated Stat1 and Stat2 Plus a 48-kDa Protein All Contact DNA in Forming Interferon- … - Full text - MIT Libraries
SA Qureshi, M Salditt-Georgieff, JE Darnell Jr - Proceedings of the National Academy of Sciences - pnas.org
... the Signal Transducer and Activator of Transcription (STAT3) Isoform J ... Affinity
Chromatography Identifies Multiple Interferon-alpha-regulated Stat2 Complexes J ...
Cited by 93 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets - Full text - MIT Libraries
Y Miyakawa, A Oda, BJ Druker, H Miyazaki, M Handa, … - Mol. Endocrinol, 2002 - bloodjournal.org
... to thrombopoietin. We immunologically identified Stat1, Stat2, Stat3, and
Stat5 in human platelet lysates. Thrombopoietin induced ...
Cited by 43 - Web Search - ncbi.nlm.nih.gov

The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2 - Full text - MIT Libraries
R Yan, S Qureshi, Z Zhong, Z Wen, JE Darnell Jr - Nucleic Acids Res, 1995 - pubmedcentral.nih.gov
... There are 24 exons in the Stat2 gene and a matching number in very ... Stat3: a STAT
family member activated by tyrosine phosphorylation in response to epidermal ...
Cited by 22 - Web Search - nar.oupjournals.org - ncbi.nlm.nih.gov

STAT3 ubiquitylation and degradation by mumps virus suppress cytokine and oncogene signaling - Full text - MIT Libraries
CM Ulane, JJ Rodriguez, JP Parisien, CM Horvath - J. Virol, 2003 - jvi.asm.org
... single mumps virus protein, called V, that assembles STAT-directed ubiquitylation
complexes from cellular components, including STAT1, STAT2, STAT3, DDB1, and ...
Cited by 20 - Web Search - pubmedcentral.nih.gov - biochem.northwestern.edu - dx.doi.org - all 7 versions »

STAT3 Activation by Type I Interferons Is Dependent on Specific Tyrosines Located in the Cytoplasmic … - Full text - MIT Libraries
JL Yang, XJ Qu, PJ Russell, D Goldstein, H … - J. Biol. Chem, 2002 - jbc.org
... The role of STAT1 and STAT2 in IFN-dependent JAK-STAT signaling is well established;
however, the role of STAT3 and its activation by IFNs remains unclear. ...
Cited by 7 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of … - Full text - MIT Libraries
U Hemmann, C Gerhartz, B Heesel, J Sasse, G … - J. Biol. Chem, 1996 - jbc.org
... An analogous result was recently generated using Stat1/Stat2 chimeras (46). Secondly,
chimera Stat3/1[SH2] showed the same pattern of activation through gp130 ...
Cited by 117 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Stat3 and Stat4: Members of the Family of Signal Transducers and Activators of Transcription - Full text - MIT Libraries
Z Zhong, Z Wen, JE Darnell Jr - Proceedings of the National Academy of Sciences - pnas.org
... the Signal Transducer and Activator of Transcription (STAT3) Isoform J ... Affinity
Chromatography Identifies Multiple Interferon-alpha-regulated Stat2 Complexes J ...
Cited by 121 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and … - Full text - MIT Libraries
X Li, S Leung, IM Kerr, GR Stark - Mol. Cell. Biol, 1997 - mcb.asm.org
... Furthermore, the preassociation is specific for STAT2 and STAT1, since STAT3
and STAT5 did not bind to the fusion protein (data not shown). ...
Cited by 67 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Activation and association of Stat3 with Src in v-Src-transformed cell lines - Full text - MIT Libraries
X Cao, A Tay, GR Guy, YH Tan - Mol Cell Biol, 1996 - mcb.asm.org
... Unlike Stat1, however, Stat3 is not activated by IFN- ; neither does it form
a complex with Stat2 or bind to the ISRE after IFN- treatment. ...
Cited by 162 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Cooperative transcriptional activity of Jun and Stat3f3, a short form of Stat3 - Full text - MIT Libraries
TS SCHAEFER, LK SANDERS, D NATHANS - Proc. Natl. Acad. Sci. USA, 1995 - pnas.org
... genes (5). Stat3 was identified by the low-stringency hybridization of its cDNA
to a Statl probe derived from a region conserved between Statl and Stat2 (6, ...
Cited by 165 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Mutational analysis of acute-phase response factor/Stat3 activation and dimerization - Full text - MIT Libraries
J Sasse, U Hemmann, C Schwartz, U Schniertshauer, … - Mol. Cell. Biol, 1997 - mcb.asm.org
... Stat1-Stat3 heterodimers (40). Recent evidence in- dicated the existence of
Stat2-Stat3 heterodimers (12). In con- trast, Stat4, Stat5 ...
Cited by 38 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

IFN-alpha activates Stat6 and leads to the formation of Stat2: Stat6 complexes in B cells - Full text - MIT Libraries
S Gupta, M Jiang, AB Pernis - J. Immunol, 1999 - jimmunol.org
... 1 . Ab interference mobility shift assays were conducted by addition of antisera
against Stat1, Stat2, Stat3, Stat5, or Stat6 or preimmune serum (control). ...
Cited by 15 - Web Search - jimmunol.org - cpmcnet.columbia.edu - ncbi.nlm.nih.gov - all 8 versions »

Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG … - Full text - MIT Libraries
M Nielsen, K Kaltoft, M Nordahl, C Ropke, C … - Proc Natl Acad Sci USA, 1997 - dx.doi.org
... Thus, neither the fast migrating isoform of Stat3 (Stat3 fm ) nor other Stats (Stat1,
Stat2, and Stat4 through Stat6) were constitutively activated. ...
Cited by 77 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

CILIARY NEUROTROPHIC FACTOR AND PHORBOL ESTER EACH DECREASE SELECTED STAT3 POOLS IN NEUROBLASTOMA … - Full text - MIT Libraries
RL Malek, SW Halvorsen, H Drissi, M Lieberherr, M … - Cytokine, 1999 - ingentaconnect.com
... neuroblastoma cells with the phorbol ester, 12- O -tetradecanoylphorbol 13-acetate
(TPA), for 4–5 h caused a 60% decline in both STAT2 and STAT3 levels and ...
Cited by 9 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 4 versions »

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T … - Full text - MIT Libraries
C Beadling, D Guschin, BA Witthuhn, A Ziemiecki, … - J. Immunol, 2005 - embojournal.npgjournals.com
... IFN alpha activated STAT1, STAT2 and STAT3 in T cells, but no detectable activation
of these STATs was induced by IL-2. However, IL-2 regulates the DNA binding ...
Cited by 84 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-{alpha}–stimulated … - Full text - MIT Libraries
J Wang, N Pham-Mitchell, C Schindler, IL Campbell - J. Clin. Invest, 2003 - jci.org
... Therefore, despite STAT2 deficiency, STAT1, STAT3, and STAT5 were all activated
and STAT1 levels strongly upregulated in the presence of IFN- in the cerebellum ...
Cited by 10 - Web Search - jci.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Stat1 and Stat2 but Not Stat3 Arbitrate Contradictory Growth Signals Elicited by Alpha/Beta … - Full text - MIT Libraries
R Gimeno, CK Lee, C Schindler, DE Levy - Mol Cell Biol, 2005 - mcb.asm.org
... STAT2 and STAT3 were the most highly phosphorylated STAT proteins in response to
IFN- /ß treatment in the absence of STAT1 (Fig. 5 and data not shown). ...
Web Search - mcb.asm.org - ncbi.nlm.nih.gov

[CITATION] type I interferon (IFN/) pathway that uses STAT1 and STAT2 (26), the type II interferon (IFN) …
J EMBO, J EMBO - EMBO J, 1991
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Stat2 (C-20): sc-476
I Santa Cruz Biotechnology - genetimes.com.cn
... with Stat2 p113 of human origin by Western blotting, immunoprecipitation and
immunohisto- chemistry; non cross-reactive with Stat1α p91, Stat1β p84, Stat3 p92 ...
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Stat2 (N-17): sc-839
I Santa Cruz Biotechnology - genetimes.com.cn
... N-17) reacts with Stat2 p113 of human origin by Western blotting and
immunohistochemistry; non cross- reactive with Stat1α p91, Stat1β p84, Stat3 p92, ...
View as HTML - Web Search

Stat2 (A-7): sc-1668
I Santa Cruz Biotechnology - genetimes.com.cn
... A-7) reacts with Stat2 p113 of human origin by Western blotting and
immunohistochemistry; non cross- reactive with Stat1α p91, Stat1β p84, Stat3 p92, ...
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Stat2 (L-20): sc-950
I Santa Cruz Biotechnology - genetimes.com.cn
... 20) reacts with Stat2 p113 of mouse and rat origin by Western blotting and
immunohistochemistry; non cross- reactive with Stat1α p91, Stat1β p84, Stat3, Stat4 ...
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Catalytically Active TYK2 Is Essential for Interferon--mediated Phosphorylation of STAT3 and …
EN Fish, A Wolfman, RM Ransohoff - jbc.org
... Blots were probed with antibody to STAT1 and STAT2 (top panel) and to STAT3 (bottom
panel). C, positive control: extract from IFN- -treated U266 cells. ...
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Stat3 (K-15): sc-483
I Santa Cruz Biotechnology - genetimes.com.cn
... Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the
ISGF3 transcription factor complex (3). Although early reports indicate Stat3 ...
View as HTML - Web Search

Stat3 (C-20): sc-482
I Santa Cruz Biotechnology - genetimes.com.cn
... Stat3 (C-20) reacts with Stat3 p92 of mouse, rat and human origin ... and
immunohistochemistry; non cross-reactive with Stat1α p91, Stat1β p84, Stat2 p113, ...
View as HTML - Web Search - cosmobio.co.jp

Polyclonal Antibody to STAT2
S React, A Notes, R Products - imgenex.com
... Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), Stat1,
Stat3, Stat5a, and Stat5b have a wide activation profile (4,5). Human ...
View as HTML - Web Search - imgenex.com

The genomic structure and chromosomal localization of the mouse STAT3 gene - Full text - MIT Libraries
W Shi, M Inoue, M Minami, K Takeda, M Matsumoto, Y … - Int Immunol, 1996 - intimm.oupjournals.org
... The structure of the mouse STAT3 gene was almost identical to that of the human
STAT2 gene, including the number and size of exons, indicating that the exon ...
Cited by 11 - Web Search - ncbi.nlm.nih.gov

p-Stat3 (B-7): sc-8059
S CRUZ - scbt.com
... Stat1 and Stat2 are induced by IFN-α and form a heterodimer which is part of the
ISGF3 transcription factor complex (3). Although early reports indicate Stat3 ...
View as HTML - Web Search

Three-dimensional structure of the Stat3 homodimer bound to DNA - Full text - MIT Libraries
S Becker, B Groner, CW Muller - Nature, 1998 - nature.com
... b, Sequence alignment of mouse Stat3 with human homologues Stat1, Stat2, Stat4,
Stat5 and Stat6 and Lck, Src and Abl SH2 domains (program CLUSTALW, manually ...
Cited by 21 - Web Search

Function of Stat2 protein in transcriptional activation by alpha interferon - Full text - MIT Libraries
SA Qureshi, S Leung, IM Kerr, GR Stark, JE Darnell … - Mol Cell Biol, 1996 - mcb.asm.org
... Stat1 has a required serine residue for IFN- induction in a sequence that is conserved
between Stat1, Stat3, Stat4, and Stat5 (33). In con- trast, Stat2 has a ...
Cited by 60 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

STAT ANTIBODY SAMPLER PACK
A DESCRIPTIONS - zymed.com
... Specificity STAT1α STAT2 STAT3 STAT4 STAT5a STAT5b STAT5(pan) STAT6 Host/Type
Ms/Mono Rb/Poly Ms/Mono Ms/Mono Ms/Mono Ms/Mono Ms/Mono Ms/Mono ...
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Activation of the Jak-Stat Pathway in Cells That Exhibit Selective Sensitivity to the Antiviral …
IM GRUMBACH, EN FISH, S UDDIN, B MAJCHRZAK, OR … - JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 1999 - dx.doi.org
... Tyk2. Polyclonal antibodies against Stat1, Stat2, and Stat3 were purchased
from Santa Cruz Biotechnology (Santa Cruz, CA). Another ...
Cited by 14 - Web Search - liebertonline.com - liebertonline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Steel factor induces serine phosphorylation of Stat3 in human growth factor-dependent myeloid cell … - Full text - MIT Libraries
A Gotoh, H Takahira, C Mantel, S Litz-Jackson, HS … - Blood, 1996 - bloodjournal.org
... Anti-Stat2, Stat3, Stad, and Stat6 monoclonal antibodies (MoAbs), anti-ISGF3 poly-
clonal Ab, and anti-phosphotyrosine MoAb (PY20) were purchased from ...
Cited by 27 - Web Search - bloodjournal.org - bloodjournal.org - ncbi.nlm.nih.gov

Characterization of phosphopeptide motifs specific for the src homology 2 (SH2) domains of signal … - Full text - MIT Libraries
M Wiederkehr-Adam, P Ernst, K Mueller, E Bieck, FO … - J. Biol. Chem, 2004 - jbc.org
... transcription 1 (STAT1) and STAT3 Michèle Wiederkehr-Adam*, Philipp Ernst*, Kurt
Müller†, Elke Bieck*, Frank O. ... Phosphopeptide binding of STAT1 and STAT3 ...
Cited by 8 - Web Search - jbc.org - ncbi.nlm.nih.gov

Identification of a novel Stat3 recruitment and activation motif within the granulocyte colony- … - Full text - MIT Libraries
A Chakraborty, KF Dyer, M Cascio, TA Mietzner, DJ … - Blood, 1999 - bloodjournal.org
... Grb-2. Also included in the CLUSTAL analysis for comparison were the sequences of
identified homologues of Stat3: the SH2 domains of Stat1, Stat2, Stat4, Stat5A ...
Cited by 27 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Role of angiotensin II in activation of the JAK/STAT pathway induced by acute pressure overload in … - Full text - MIT Libraries
J Pan, K Fukuda, H Kodama, S Makino, T Takahashi, … - Circ Res, 1997 - circresaha.org
... Western blot analysis revealed that pressure overload activated JAK1, JAK2, and
Tyk2 as early as 5 minutes and that STAT1, STAT2, and STAT3 were tyrosine ...
Cited by 69 - Web Search - intl-circres.ahajournals.org - circres.ahajournals.org - ncbi.nlm.nih.gov - all 5 versions »

Stat Protein Transactivation Domains Recruit p 300/CBP through Widely Divergent Sequences - Full text - MIT Libraries
M Paulson, S Pisharody, L Pan, S Guadagno, AL Mui, … - J Biol Chem, 1999 - jbc.org
... Note that the Stat1 construct contains the full-length protein, while Stat2 and
Stat3 were carboxyl-terminal fusions. IP, immunoprecipitated. ...
Cited by 82 - Web Search - jbc.org - ncbi.nlm.nih.gov

Activation of Stat3 Transcription Factor by Herpesvirus Saimiri STP-A Oncoprotein - Full text - MIT Libraries
YH Chung, NH Cho, MI Garcia, SH Lee, P Feng, JU … - J Virol, 2004 - pubmedcentral.nih.gov
... Stat1, Stat2, and Stat3 were expressed at equivalent levels (Fig. 2A). ... We found that
STP-A11 efficiently interacted with Stat3 but not with Stat1 or Stat2. ...
Cited by 4 - Web Search - jvi.asm.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Role of Stat3 in lipopolysaccharide-induced IL-10 gene expression - Full text - MIT Libraries
EM Benkhart, M Siedlar, A Wedel, T Werner, HW … - J. Immunol, 2000 - jimmunol.org
... The following Abs were purchased from Santa Cruz Biotechnology (Santa Cruz, CA):
Stat1 p84/p91, sc-346; Stat2, sc-839; Stat3, sc-483; Stat3, sc-7179; Stat4, sc ...
Cited by 42 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 6 versions »

STAT Family Screening Kit
L No - activemotif.com
... Approximate molecular weights STAT1 alpha: 91 kDa STAT2: 113 kDa STAT3: 86 and 91
kDa STAT4: 84 kDa STAT5A: 94 kDa STAT5B: 92 kDa STAT6: 100 kDa ...
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