Signaling inputs converge on nuclear effectors in TGF-b signaling - Full text - MIT Libraries
P ten Dijke, K Miyazono, CH Heldin - Trends Biochem. Sci, 2000 - chemistry.montana.edu
... factor might not always inter- act directly with each other; Stat3 and Smad1 ... TGIF
Smad2 MH2 Transcriptional co-repressor; recruits histone deacetylase activity ...
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Androgen receptor corepressors: An overview
L Wang, CL Hsu, C Chang, U andtheCancerCenter, NY … - The Prostate, 2005 - doi.wiley.com
... responsive transcription, cyclin D1 suppresses the transactivation of AR, STAT3,
and TR ... TGIF DBD The transcriptional repression of AR by TGIF is mainly mediated ...
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Smad Proteins Suppress CCAAT/Enhancer-binding Protein(C/EBP) beta- and STAT 3-mediated … - Full text - MIT Libraries
A Zauberman, S Lapter, D Zipori - J Biol Chem, 2001 - jbc.org
... TGIF (TG-interacting factor) and c-Ski repress TGF -mediated transcription by ... other
studies have implied that TGF controls C/EBP - or STAT3-mediated pathways. ...
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The role of Smads in BMP signaling
R Nishimura, K HATA, F IKEDA, T Matsubara, K … - Front. Biosci, 2003 - bioscience.org
... E: When Smad complex associates with repressor, TGIF, Ski or SnoN, the ... Smad complex
directly or indirectly associates with LEF/b-catenin, Stat3 or vitamin D ...
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Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT - Full text - MIT Libraries
J Long, I Matsuura, D He, G Wang, K Shuai, F Liu - Proceedings of the National Academy of Sciences, 2003 - pnas.org
... The interactions between Smad2 and Smad3 with TGIF, and the interactions among Smad2 ...
PIAS1 and PIAS3 bind and inhibit STAT1 and STAT3 DNA-binding activities ...
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How cells read TGF-beta signals - Full text - MIT Libraries
J Massague - Nat Rev Mol Cell Biol, 2000 - nature.com
... Thrombospondin Activin SHH SHH BMP LEF1/TCF CBFA1 CBFA3 Mixer STAT3 JUN Wnt BMP
TGF-β Xnr LIF TNF-α ... Ski/SnoN Corepressors TGIF Signalling receptors ...
Cited by 286 - Web Search - bio.kaist.ac.kr - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Stat1-dependent and-independent pathways in IFN-γ-dependent signaling - Full text - MIT Libraries
CV Ramana, M Gil, RD Schreiber, GR Stark - J. Immunol - chosun.ac.kr
... the tyrosine phosphorylation and activation of Stat1 and Stat3 [23]. ... 5.5 Regulation;
phosphatase MIP-2 – 5.4 Secreted; chemokine TGIF –4.4 Transcriptional ...
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Transcription activator protein 1 (AP-1) mediates D-but not E-adrenergic hypertrophic growth …
G Taimor, KD Schlueter, P Best, S Helmig, HM Piper - intl-ajpheart.physiology.org
... Jun can also interact with diverse transcriptional repressors such as TGIF or
Ski or with other transcription factors, eg STAT3 (14, 15, 21). ...
Web Search

NEW EMBO MEMBER'S REVIEW Transcriptional control by the TGF-b/Smad signaling system - Full text - MIT Libraries
J MassagueA, D Wotton - The EMBO Journal, 2000 - emboj.org
... astrocyte formation is mediated by a complex between Smad1 and Stat3 bridged by ... TGIF
ASmad complex bound to DNAhas the option to recruit not only coactivators ...
Cited by 107 - Web Search - nature.com

A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal … - Full text - MIT Libraries
RH Kim, D Wang, M Tsang, J Martin, C Huff, MP de … - Genes Dev, 2000 - genesdev.org
... 1999 ), TGIF, which recruits the histone deacetylase HDAC (Wotton et al. ... with a number
of transcription factors such as Stat2 and Stat3 (Bhattacharya et al. ...
Cited by 49 - Web Search - stke.org - benaroyaresearch.org - all 10 versions »

NEW EMBO MEMBER’S REVIEW - Full text - MIT Libraries
J Massague, D Wotton - The EMBO Journal, 2000 - embojournal.npgjournals.com
... LIF in astrocyte formation is mediated by a complex between Smad1 and Stat3 bridged
by ... TGIF A Smad complex bound to DNA has the option to recruit not only ...
Cited by 4 - Web Search - emboj.org - pubmedcentral.nih.gov

HOW CELLS READ TGF-< img border='0' src='/__chars/beta/black/med/base/glyph. gif' align='middle' alt … - Full text - MIT Libraries
J Massague - Nature Reviews Molecular Cell Biology - nature.com
1. Massagué, J. TGF signal transduction. Annu. Rev. Biochem. 67, 753-791
(1998). | Article | PubMed | ISI | ChemPort |. 2. Schier ...
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Divergence and convergence of TGF-b/BMP signaling - Full text - MIT Libraries
K Miyazono, K Kusanagi, H Inoue - J. Cell Physiol, 2001 - doi.wiley.com
... Moses, 2000); TAK1 (Kimura et al., 2000); TFE3 (Hua et al., 1999); TGIF (Wotton
et ... but it has been shown that BR-Smads indirectly interact with STAT3 through a ...
Cited by 135 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Selective inhibition of TGF-bold italic beta responsive genes by Smad-interacting peptide aptamers … - Full text - MIT Libraries
Q Cui, SK Lim, B Zhao, FM Hoffmann - Oncogene, 2005 - nature.com
... et al., 2000; Pardali et al., 2000b), TFE3 (Hua et al., 1998), TGIF (Wotton et ... 1997),
p300-HIF-1 (Kung et al., 2000), EGF receptor−Stat3 interaction (Buerger ...
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The Transcriptome Profile of Human Embryonic Stem Cells as Defined by SAGE - Full text - MIT Libraries
M Richards, SP Tan, JH Tan, WK Chan, A Bongso - Stem Cells, 2004 - intl-stemcells.alphamedpress.org
... In contrast, members of the leukemia inhibitory factor (LIF) signaling pathway
(STAT3, LIF, LIFR ... 15, 20, 21, 26], and eight of them, including TGIF, TDGF1, CHEK2 ...
Cited by 23 - Web Search - dx.doi.org - stemcells.alphamedpress.org - ncbi.nlm.nih.gov - all 6 versions »

Signaling of transforming growth factor-b family members through Smad proteins
S Itoh, F Itoh, MJA Goumans, P ten Dijke - cancer - ingentaconnect.com
... The expression level of corepres- sors Ski and TGIF may control the magnitude of
TGF ... STAT3, which is activated by LIF, was found to interact indirectly with BMP ...
Cited by 41 - Web Search

Statistical methods for joint data mining of gene expression and DNA sequence database
MD Curran, H Liu, F Long, N Ge - SIGKDD Explorations Special Issue on Microarray Data Mining, 2003 - portal.acm.org
... OCT-x OCT1 -- OCT_C 42.1% STAT1 STAT3 -- STAT_C 71.8% NF-kappaB NF-kappaB (p65)
c-Rel NFkcR_C 77.9% ... Arnt Max -- ArMx_C 0.0% MEIS1 TGIF -- MsTGIF_C 5.6% ...
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Identification of genes regulated during osteoblastic differentiation by genome-wide expression …
S Roman-Roman, T Garcia, A Jackson, J Theilhaber, … - Bone, 2003 - proskelia.com
... the calvaria maturation time course, NF B p65 and p105, FKHR, Stat3 ATFx, PTTG ... to
note the opposed regulation of two inhibitors of Smad signaling, TGIF (up) and ...
Cited by 6 - View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Activin Inhibits Pituitary Prolactin Expression and Cell Growth through Smads, Pit-1 and Menin - Full text - MIT Libraries
A Lacerte, EH Lee, R Reynaud, L Canaff, C de Guise … - Molecular Endocrinology - mend.endojournals.org
... indicated specific antibody overnight at 4 C [menin (62), stat3 (Santa Cruz ... J 1999
Multiple modes of repression by the Smad transcriptional corepressor TGIF. ...
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Signaling of transforming growth factor-beta family members through Smad proteins - Full text - MIT Libraries
S Itoh, F Itoh, MJ Goumans, P ten Dijke - European Journal of Biochemistry, 2000 - content.febsjournal.org
... activated kinase; Tcf, T-cell factor; TFE, transcription factor mu E3; TGIF, 5'TG ...
STAT3, which is activated by LIF, was found to interact indirectly with BMP ...
Cited by 95 - Cached - Web Search - ejbiochem.org - blackwell-synergy.com - ncbi.nlm.nih.gov - all 6 versions »

Epidermal growth factor receptor and signal transduction: potential targets for anti-cancer therapy - Full text - MIT Libraries
E Targeting, C Articles - Anti-Cancer Drugs, 2005 - anti-cancerdrugs.com
... Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. ...
factor signaling via Ras controls the Smad transcriptional co-repressor TGIF. ...
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HOW CELLS READ TGF-bold beta SIGNALS - Full text - MIT Libraries
J Massague - Nature Reviews Molecular Cell Biology, 2000 - nature.com
... region and increase the level of the SMAD corepressor TGIF by stabilizing ... In a related
example, STAT3, activated by the cytokine leukaemia inhibitory factor ...
Web Search - nature.com

AP-1 as a regulator of cell life and death - Full text - MIT Libraries
E Shaulian, M Karin - Nature Cell Biology, 2002 - nature.com
... Pessah, M. et al. c-Jun interacts with the corepressor TG-interacting factor (TGIF)
to suppress Smad2 transcriptional activity. Proc. Natl Acad. Sci. ...
Cited by 210 - Web Search - nature.com - ncbi.nlm.nih.gov

Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by … - Full text - MIT Libraries
AA Postigo, JL Depp, JJ Taylor, KL Kroll - The EMBO Journal, 2003 - embojournal.npgjournals.com
... TGIF also recruits CtBP to repress Smads but it does not require direct binding
to DNA to ... has also been shown to act as a bridge between Smad1 and Stat3 in the ...
Cited by 8 - Web Search - emboj.org - molecool.wustl.edu - nature.com - all 9 versions »

Induction of Ectopic Olfactory Structures and Bone Morphogenetic Protein Inhibition by Rossy, a … - Full text - MIT Libraries
I Munoz-Sanjuan, AH Brivanlou - Mol Cell Biol, 2005 - mcb.asm.org
... recruitment of transcriptional corepressors (such as Ski, SnoN, and TGIF [49, 55,
60 ... and basic fibroblast growth factor (bFGF)/Ras, Wnt, or Stat3 signaling in ...
Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta … - Full text - MIT Libraries
M KAWABATA, T IMAMURA, H INOUE, JI HANAI, A … - J. Immunol, 2004 - dx.doi.org
... Smad transcriptional activity by protein inhibitor of activated STAT3 (PIAS3) PNAS ...
c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress ...
Web Search - dx.doi.org - pnas.org - pnas.org

Regulation of cell proliferation by Smad proteins - Full text - MIT Libraries
P Ten Dijke, MJ Goumans, F Itoh, S Itoh - Journal of Cellular Physiology, 2002 - doi.wiley.com
... For example, Stat3 activated by LIF was found to indirectly associate with BMP ... The
co-repressor TGIF, a homeodomain-containing protein which recruits histone ...
Cited by 87 - Web Search - ncbi.nlm.nih.gov

Transforming growth factor ß signal transduction
S Dennler, MJ Goumans, P ten Dijke - J Leukoc Biol, 2002 - jleukbio.org
... TGIF can interact directly with HDAC, whereas c-Ski and SnoN interact indirectly ...
2 induces apoptosis in human myeloma cells with modulation of STAT3 Blood 96 ...
Cited by 30 - Web Search - jleukbio.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Journal of Carcinogenesis - Full text - MIT Libraries
MJ van Erk, E Teuling, YCM Staal, S Huybers, PJ … - Journal of Carcinogenesis, 2004 - bmc.ub.uni-potsdam.de
... and activator of transcription 3 (acute-phase response factor) STAT3 1.56 1.19 ... R83270
TGFB-induced factor (TALE family homeobox) TGIF -1.97 -1.06 Transcription ...
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Interaction and functional cooperation of NFκB with Smads - Full text - MIT Libraries
T Lopez-Rovira, E Chalaux, JL Rosa, R Bartrons, F … - J. Biol. Chem, 2000 - jbc.org
... sites on responsive promoters, as described for FAST, TFE3, or Stat3, or through ...
by binding to factors recruiting histone deacetylases such as TGIF (56) or ...
Cited by 41 - Web Search - jbc.org - ub.es - ncbi.nlm.nih.gov

Novel transcription factors in human CD34 antigen-positive hematopoietic cells - Full text - MIT Libraries
I Gomes, TT Sharma, S Edassery, N Fulton, BG Mar, … - Blood, 2002 - bloodjournal.org
... Transcription Hs.321677 STAT3 Signal transducer and activator of
transcription 3 (acute-phase response factor) 17q21 437.5 VH W ...
Cited by 3 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

The shape of the messenger: using protein structure information to design novel cytokine-based …
CH Schein - Curr Pharm Design, 2002 - ingentaconnect.com
... T-cell growth factor CSIF: cytokine synthesis inhibitory factor TGIF: T-cell ... subunits
are expressed in skin and upregulated in psoriasis, signals through STAT3 ...
Cited by 13 - Web Search - virologyj.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

TGF-β signaling in mammary gland development and tumorigenesis
LM Wakefield, E Piek, EP Bottinger - J. Mammary Gland Biol. Neoplasia, 2001 - kluweronline.com
... of proto-oncogenes and the homeodomain protein TGIF, which function ... In thenucleus,
thevitaminDreceptor,theglucocorticoid receptor and Stat3 are all examples of ...
Cited by 9 - Web Search - springerlink.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molecular aspects of vertebrate retinal development
SS Zhang, XY Fu, CJ Barnstable - Mol. Neurobiol, 2002 - biomed.humanapress.com
... The intracellular signaling molecule Stat3 shows a pattern of expression during
develop- ment consistent with a role in generation of neuronal ... TGIF TF – (69) ...
Cited by 9 - Web Search - neurosci.humanapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

French society of immunology, cytokines
A et Biotech - john-libbey-eurotext.fr
... IL-7Ralpha and hTSLPR, by IL-50 leads to phosphorylation of STAT3 and STAT5 ... c-Jun
interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 ...
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Leiomyoma and Myometrial Gene Expression Profiles and Their Response to Gonadotropin Releasing …
X Luo, L Ding, J Xu, RS Williams, N Chegini - Endocrinology (submitted), 2004 - endo.endojournals.org
... TGIF may serve as an additional downstream mechanism altering TGF-β actions in
leiomyoma (35). ... of NFκ-B, STAT3, Myc, Rb, C/EBP, CBP/p300, E2F and AP1 (82). ...
Cited by 1 - Web Search - endo.endojournals.org

Cross-talk between glucocorticoid and retinoic acid signals involving glucocorticoid receptor … - Full text - MIT Libraries
N Subramaniam, J Campion, I Rafter, S Okret - Biochem J, 2003 - biochemj.org
... Z., Jones, S., Hagood, JS, Fuentes, NL and Fuller, GM (1997) STAT3 acts as ... KNOX,
Iroquois, TGIF) reveals a novel domain conserved between plants and animals. ...
Cited by 6 - View as HTML - Web Search - biochemj.org - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

CHIP Mediates Degradation of Smad Proteins and Potentially Regulates Smad-Induced Transcription - Full text - MIT Libraries
L Li, H Xin, X Xu, M Huang, X Zhang, Y Chen, S … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... partner proteins, such as SIP1, Ski, SNIP1, Evi-1, and TGIF, were identified ...
overexpression of CHIP had no effect on the unrelated protein (STAT3) level (Fig. ...
Cited by 3 - Web Search - utminers.utep.edu - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

Microarray analysis of gene expression in human donor sclera - Full text - MIT Libraries
TL Young, GS Scavello, PC Paluru, JD Choi, EF … - Mol Vis, 2004 - molvis.org
Page 1. Molecular Vision 2004; 10:163-76 <http://www.molvis.org/molvis/v10/a22>
Received 3 October 2003 | Accepted 16 March 2004 | Published 22 March 2004 ...
Cited by 3 - View as HTML - Web Search - molvis.org - scavello.net - ncbi.nlm.nih.gov

Synergistic Cooperation between Hypoxia and Transforming Growth Factor-beta Pathways on Human … - Full text - MIT Libraries
T Sanchez-Elsner, LM Botella, B Velasco, A Corbi, … - J Biol Chem, 2001 - intl.jbc.org
... bind independently and transactivate target gene promoters; Smad1 and STAT3, bridged
by ... Smads with the adenoviral oncoprotein E1A (20), with the TGIF factor (21 ...
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AML1 interconnected pathways of leukemogenesis
J Michaud, HS Scott, R Escher - Cancer Invest, 2003 - taylorandfrancis.metapress.com
... Transcription activators STAT3 d Signal transducer and acti- vator of transcription
3 Not specific In silico [223] Constitutive expression [57] ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Transcriptional regulation by the MAP kinase signaling cascades - Full text - MIT Libraries
SH Yang, AD Sharrocks, AJ Whitmarsh - Gene, 2003 - www-unix.oit.umass.edu
... TIF-1A ERK, RSK 75 STAT3 ERK, JNK, p38, MSK 60, 76 p65 (NFnB) MSK 77 Coregulatory
proteins CBP, p300, SRC-1, GRIP-1, PBP, AIB1, TGIF ERK 77–84 PGC-1 p38 85 ...
Cited by 48 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Crossing Smads
JL Wrana - Sci STKE, 2000 - stke.org
... specific gene 1 (MSG1) (3). Alternatively, in some instances Smads can negatively
regulate transcription by recruiting corepressors such as TGIF or the ...
Cited by 18 - Cached - Web Search - people.sabanciuniv.edu - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Signalling by TGF-
J Qing, R Derynck - ucsf.edu
... by other Smad- interacting corepressors, such as the c-Ski-related SnoN, TGIF, SNIP
and ... activated Smad1 has been shown to form a complex with STAT3, which was ...
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Ueber die Funktion von Zinkfinger Proteinen bei der Induktion des Mesoderms in Xenopus laevis
U Duerr - webdoc.gwdg.de
Page 1. Über die Funktion von Zinkfinger Proteinen bei der Induktion des Mesoderms
in Xenopus laevis Dissertation zur Erlangung des Doktorgrades ...
View as HTML - Web Search - webdoc.sub.gwdg.de - deposit.ddb.de

Transcription activator protein 1 mediates {alpha}-but not {beta}-adrenergic hypertrophic growth … - Full text - MIT Libraries
G Taimor, KD Schluter, P Best, S Helmig, HM Piper - Am J Physiol Heart Circ Physiol, 2004 - intl-ajpheart.physiology.org
... and Atfi A. c-Jun interacts with the corepressor TG-interacting factor (TGIF) to
suppress ... Vellenga E, and Kruijer W. c-Jun and c-Fos cooperate with STAT3 in IL ...
Cited by 1 - Web Search - intl-ajpheart.physiology.org - ncbi.nlm.nih.gov

Gene expression changes during mouse skeletal myoblast differentiation revealed by transcriptional … - Full text - MIT Libraries
JL Moran, Y Li, AA Hill, WM Mounts, CP Miller - Physiol Genomics, 2002 - physiolgenomics.physiology.org
... increasing during muscle differentiation include MyoD1, Six1, Stat3, Hes6,
Klf4 and Osf2 (Figure 5A). Members of the Id gene family ...
Cited by 6 - Web Search - intl-physiolgenomics.physiology.org - intl-physiolgenomics.physiology.org - ncbi.nlm.nih.gov - all 5 versions »

Critical Review
M Karin, E Shaulian - Life, 2001 - dx.doi.org
Page 1. IUBMB Life , 52: 17 – 24, 2001 Copyright c° 2001 IUBMB 1521-6543/01 $12.00 +
.00 Critical Review AP-1: Linking Hydrogen Peroxide and Oxidative Stress ...
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TGF-bold beta signaling in tumor suppression and cancer progression - Full text - MIT Libraries
R Derynck, RJ Akhurst, A Balmain - Nature Genetics, 2001 - nature.com
... The corepressors Evi-1 (ref. 62) and c-Ski (ref. 63,64), as well as SnoN
(ref. 65), TGIF (ref. 66), SNIP1 (ref. 67) and SIP1 (ref. ...
Cited by 277 - Web Search - mcb.mcgill.ca - radiationbiology.dk - ucsf.edu - all 6 versions »

TIEG proteins join the Smads as TGF-beta-regulated transcription factors that control pancreatic … - Full text - MIT Libraries
T Cook, R Urrutia - Am J Physiol Gastrointest Liver Physiol, 2000 - ajpgi.physiology.org
... Conversely, another Smad2-interacting cofactor, TG sequence-interacting factor
(TGIF), is a homeodomain protein that recruits a histone deacetylase complex to ...
Cited by 16 - Web Search - stke.org - ncbi.nlm.nih.gov - all 6 versions »