Oligo GEArray® Human Neurotrophin and Receptors Microarray
S Conditions - search.cosmobio.co.jp
... NR1I2. Transcription factors: ELK1, ETS1, JUN, MEF2C, MYC, NR1I2, STAT1, STAT2,
STAT3, STAT4, STAT5A, STAT5B, TP53. Storage Conditions ...
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Targeting STAT3 affects melanoma on multiple fronts
M Kortylewski, R Jove, H Yu - Cancer and Metastasis Reviews, 2005 - springerlink.com
... p53 expression by either overexpressing HOXA5 [83] or targeting STAT3 results in
tumor ... Low incidence of TP53 mutations in 10% of familial human melanomas is ...
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Technology Insight: identification of biomarkers with tissue microarray technology
JM Giltnane, DL Rimm - Nature Clinical Practice Oncology, 2004 - tissuearray.org
... Lymphoma—classical Hodgkins Garcia 2003 14 288 29 biomarkers including
BAX, BCL2, BCL2L1, CDKN1A, MIB1, TP53, STAT3 Biomarker ...
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349 Gene expression analysis of colorectal tumors using high density oligonucleotide microchips
W DIETMAIER, U BREHM, A KOEHLER, H AUER, F … - ingentaconnect.com
... Group 3: STAT3(P)- /cycD1- (18 cases, 36%). ... By FISH-analysis, 11/15 (85%) PBV-DLBCL
had a monoallelic TP53- deletion, which was not found in 10 cases of CB/IB. ...
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GEArray Q Series Human EGF/PDGF Signaling Pathway Gene Array: AR-SAHS-040
FG Grouping, R Ligands, N Regulators, IS Molecules - eurogentec.be
... MEKK2), MAP3K3 (MEKK3), MAPK8 (JNK1), MAPK9 (JNK2), MAPK10 (JNK3), NFATC3 (NFAT4),
TP53. ... RhoA), JAK1, PLCG1, PLCG2, PRKCA (PKC alpha), STAT1, STAT3, STAT5A. ...
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Seventh Japanese–German workshop on molecular and cellular aspects of carcinogenesis - Full text - MIT Libraries
T Kuroki, MF Rajewsky - International Journal of Cancer, 2000 - doi.wiley.com
... Up-regulation of p27 KIP1 mRNA was STAT3-dependent, and p27 KIP1 accumulated in ... Upon
DNA damage, TP53 accumulates rapidly in the target cells and is activated ...
Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Perturbed IFN-gamma-Jak-signal transducers and activators of transcription signaling in tuberous … - Full text - MIT Libraries
N El-Hashemite, H Zhang, V Walker, KM Hoffmeister, … - Cancer Res, 2004 - cancerres.aacrjournals.org
... pSTAT1 Ser727, Upstate Signaling (Lake Placid, NY); and STAT3, BD Biosciences ... by
the mouse fibroblast cell technique and Tsc2 –/– TP53 –/– MEF lines ...
Cited by 3 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: Activation of the … - Full text - MIT Libraries
RB Amson, M Nemani, JP Roperch, D Israeli, L … - Genetics, 1996 - dx.doi.org
... with different TP53 gene dosage reveals numerous genes that are affected by TP53
dosage and ... and PB Sehgal Regulation of IL-6 Signaling by p53: STAT3- and STAT5 ...
Cited by 66 - Web Search - pnas.org - acm.caltech.edu - cmi.univ-mrs.fr - all 7 versions »

Chromosomal Instability in Oral Cancer Cells - Full text - MIT Libraries
SC Reshmi, SM Gollin - J Dent Res, 2005 - jdr.iadrjournals.org
... signal transducers, such as RAS family members, RAF1, and STAT3; transcription factors ...
Tumor suppressor genes—including FHIT, RB1, TP53, and CDKN2A (p16 INK4A ...
Web Search - jdr.iadrjournals.org - ncbi.nlm.nih.gov

Radiosensitization by inhibition of IkappaB-alpha phosphorylation in human glioma cells - Full text - MIT Libraries
GR Ding, N Honda, T Nakahara, F Tian, M Yoshida, H … - Radiat Res, 2003 - bioone.org
... of NFKB on radiosensitivity and PLD repair may be the TP53 protein. ... necessary for
suppressing embryonic stem cell differentiation involvement of STAT3: J. Biol ...
Cited by 5 - Web Search - apt.allenpress.com - bioone.org - ncbi.nlm.nih.gov - all 5 versions »

Regulation of apoptosis during mammary involution by the p53 tumor suppressor gene - Full text - MIT Libraries
DJ Jerry, ES Dickinson, AL Roberts, TK Said - J. Dairy Sci, 2002 - jds.fass.org
... Key words: p53, Stat3, involution, lactation ... The p53 tumor suppressor gene (designated
Trp53 in mouse; TP53 in humans) responds to a wide array of physiological ...
Cited by 6 - Web Search - angra.uac.pt - fass.org - ncbi.nlm.nih.gov - all 6 versions »

RNA interference as a potential tool in the treatment of leukaemia
A Borkhardt, O Heidenreich - Expert Opinion on Biological Therapy, 2004 - extenza-eps.com
... However, TP53 mutations in leukaemia are associated with a poor therapeutic ... mainly
has a differentiation-supportive and antiproliferative role, STAT3 and -5 ...
Web Search - ashley-pub.com - dx.doi.org - ingentaconnect.com - all 8 versions »

Characterization of 4 mantle cell lymphoma cell lines
HM Amin, TJ McDonnell, LJ Medeiros, GZ Rassidakis, … - Archives of Pathology and Laboratory Medicine, 2003 - arpa.allenpress.com
... 48 Conceivably, TP53 gene mutations contribute to uncontrolled cellular proliferation ...
Recently, we identified evidence that STAT3 is constitutively activated ...
Cited by 6 - Web Search - arpa.allenpress.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

GEArray Q Series Human Neurotrophin and Receptors Gene Array: AR-SAHS-018
FG Grouping - eurogentec.com
... ETS1, FOS, JUN, MEF2C, MYC, NCOA1, NELL1, RPS6KA6, STAT1, STAT2, STAT3, STAT4, STAT5A,
STAT5B Apoptosis Related Genes: APAF1, BAX, BCL2, HSPB1, TNFRSF6, TP53 ...
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Analysis of the interaction of TIP60β and PIN1 with the ets family transcription factor ETV6
CD Zhang - edoc.ub.uni-muenchen.de
... et al., 2003). TIP60 interacts with STAT3 and represses STAT3-mediated gene expression. ...
NcoA/SRC1a also play essential roles in STAT3-mediated transcriptional ...
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GEArray S Series Human Immunology Signaling Pathways Gene Array: AR-SAHS-605
FG Grouping, A Molecules, I ICAM, CS Molecules, C … - eurogentec.com
... JAK and STAT Proteins: JAK1, JAK2, JAK3, STAT1, STAT2, STAT3, STAT4, STAT5A ... MYC,
MYF5, NFKB2, NFKBIB, NFKBIE, NR4A2, PCNA, RAF1, RELA, RPS6KA5, SP1, SP3, TP53. ...
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42 nd Annual Meeting of the American Society for Cell Biology, San Francisco, California, USA, 14 … - Full text - MIT Libraries
P Kenny, A Rizki - Breast Cancer Res, 2003 - pubmedcentral.nih.gov
... results suggest that LIF is sufficient but not required for Stat3 activation, ie ...
correlated strongly with both ER-α negativity and mutations in TP53 in the ...
Web Search - dx.doi.org - citebase.eprints.org - breast-cancer-research.com - all 7 versions »

Evolutionary aspects of the genomic organization of rat chromosome 10 - Full text - MIT Libraries
A Behboudi, E Sj&ouml strand, P G&oacute mez-Fabre … - Cytogenetic and Genome Research, 2002 - content.karger.com
... Note! The genes Pld2, Eif4a1, Fxr2h, Shbg and Tp53 cannot be mapped by RH mapping
due to very low retention rates (Behboudi et al., 2002b). Fig. ...
Cited by 2 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »

A comparative analysis of relative occurrence of transcription factor binding sites in vertebrate … - Full text - MIT Libraries
M Stepanova, T Tiazhelova, M Skoblov, A Baranova - Bioinformatics, 2005 - bioinformatics.oxfordjournals.org
... found for TP53, indicating a selective pressure toward accumulation of TP53 binding
sites ... On the other hand, binding sites for factors STAT1, STAT3 and V-JUN ...
Web Search - bioinformatics.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

Medulloblastoma Sensitivity to 17-Allylamino-17-demethoxygeldanamycin Requires MEK/ERKM - Full text - MIT Libraries
C Calabrese, A Frank, K Maclean, R Gilbertson - J Biol Chem, 2003 - jbc.org
... and HSP90 mouse monoclonal antibodies (StressGen Biotechnology, Victoria, Canada),
TP53 mouse monoclonal ... of AKT1 and ERK1/2, but not p38, JNK, STAT3, or STAT5 ...
Cited by 6 - Web Search - jbc.org - ncbi.nlm.nih.gov

Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland - Full text - MIT Libraries
G Li, GW Robinson, R Lesche, H Martinez-Diaz, Z … - Development, 2002 - dev.biologists.org
... is similar to that of the tumor suppressor gene TP53 (Stokoe, 2001 ). ... phospho-BAD
(Ser136), -phospho-FKHR (Thr24)/FKHRL1 (Thr32), -phospho-STAT3 (Tyr705), and ...
Cited by 25 - Web Search - unmc.edu - mammary.nih.gov - ncbi.nlm.nih.gov - all 7 versions »

Mitogenic signaling cascades in glial tumors
GS Kapoor, DM O'Rourke - Neurosurgery, 2003 - neurosurgery-online.com
... A, Hettlich C, Freiman R, Hedley-Whyte ET, Martuza R: TP53 gene mutations ... Coqueret
O, Gascan H: Functional interaction of STAT3 transcription factor with the ...
Cited by 5 - Web Search - neurosurgery-online.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molecular genetics of head and neck cancer - Full text - MIT Libraries
LL Gleich, FN Salamone - Cancer Control, 2002 - moffitt.usf.edu
... 82 STAT3 ... 83 STAT3 expression and DNA binding are significant- ly increased
in the mucosa of patients with head and neck cancer. ...
Cited by 8 - View as HTML - Web Search - moffitt.usf.edu - ncbi.nlm.nih.gov

Cutaneous Biology BCL2 and JUNB abnormalities in primary cutaneous lymphomas - Full text - MIT Libraries
X Mao, G Orchard, DM Lillington, FJ Child, EC … - British Journal of Dermatology, 2004 - blackwell-synergy.com
... for the STAT family decreased expression of STAT2 (12q13.13, fivefold), STAT3 (17q21,
fivefold) and STAT5 (17q11.3, fivefold), for the TP53 family decreased ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Candidate nsSNPs That Can Affect the Functions and Interactions of Cell Cycle Proteins - Full text - MIT Libraries
S Savas, MF Ahmad, M Shariff, DY Kim, H Ozcelik - risk - doi.wiley.com
... cell cycle control genes such as RB1, 3 BRCA1 and BRCA2, 4 TP53, 5 NF2 ... CRK, CSNK2A1,
CSNK2B, CTNNB1, DNMT1, ESR1, HDAC1, HSPA8, HSPCA, LMNA, PSMA3, STAT3, TFDP2 ...
Web Search - ijmm.org - ncbi.nlm.nih.gov

A new member of the interleukin 10-related cytokine family encoded by a poxvirus - Full text - MIT Libraries
NW Bartlett, L Dumoutier, JC Renauld, SV Kotenko, … - J Gen Virol, 2004 - jgv.sgmjournals.org
... of transcription (STAT) signal transduction pathway, resulting in phosphorylation,
nuclear translocation and transcriptional activity of STAT3 and STAT1 ...
Cited by 1 - Web Search - vir.sgmjournals.org - jgv.sgmjournals.org - ncbi.nlm.nih.gov - all 5 versions »

Signal Transduction and Cellular Radiation Responses - Full text - MIT Libraries
RK Schmidt-Ullrich, P Dent, S Grant, RB Mikkelsen, … - Radiation Research, 2000 - bioone.org
... in the form of single- or double-strand breaks or of TP53 function. ... regulated protein
kinase (ERK)-dependent and ERK-independent pathways target STAT3 on serine ...
Cited by 84 - Web Search - apt.allenpress.com - ncbi.nlm.nih.gov - csa.com - all 6 versions »

Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high … - Full text - MIT Libraries
JD Khoury, LJ Medeiros, GZ Rassidakis, TJ … - The Journal of Pathology, 2003 - doi.wiley.com
... other mechanisms deregulating the G 1 phase of the cell cycle have been identified
in MCL, including hypermethylation and inactivation of p16 INK4a , TP53 ...
Cited by 8 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

IDENTIFICATION OF A CELL SENESCENCE GENE AT 6Q16. 3 IN BREAST CANCER CELLS Raghbir S. Athwal, Neena …
VK Zhawar, GP Kaur - mrmc-rad6.army.mil
... (2) STAT3 activation (phosphorylation) is ... Li-Fraumeni syndrome (LFS) is associated
with heterozygous germline mutations in the gene encoding p53 (TP53). ...
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Molecular cytogenetic characterization of Sezary syndrome
X Mao, DM Lillington, B Czepulkowski, R Russell- … - Genes Chromosomes and Cancer, 2003 - doi.wiley.com
... inactivation of a number of tumor-suppressor genes including TP53, CDKN2B/CDKN2A ...
Signal transducers and activators of transcrip- tion 3 and 5 (STAT3 and STAT5 ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molecularly Targeted Therapy in Acute Myeloid Leukemia - Full text - MIT Libraries
P BERNASCONI, M BONI, PM CAVIGLIANO, S CALATRONI, … - Ann. NY Acad. Sci, 2004 - annalsnyas.org
... them, nicotinamide, inhibits TP53-dependent apoptosis by antagonizing TP53
deacetylation mediated ... In particular, STAT3 and STAT5 play a crucial role in myeloid ...
Web Search - annalsnyas.org - ncbi.nlm.nih.gov

Mda-7/IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways - Full text - MIT Libraries
M Sauane, RV Gopalkrishnan, I Lebedeva, MX Mei, D … - Journal of Cellular Physiology, 2003 - doi.wiley.com
... We also examined whether the JAK-selective inhibitor, AG490, which has been shown
to effectively block STAT3 signaling (Catlett-Falcone et al., 1999; Nielsen ...
Cited by 9 - Web Search - ncbi.nlm.nih.gov

A Maximum Entropy Approach to Biomedical Named Entity Recognition
YF Lin, TH Tsai, WC Chou, KP Wu, TY Sung, WL Hsu - iasl.iis.sinica.edu.tw
... p53 is a syn- onym for the gene TP53 in HUGO nomenclature; but in ... PKC, calcineurin,
molecules, GM-CSF, GATA-1, IL- 12, subunit, cell, STAT3, family, antibody ...
Cited by 1 - View as HTML - Web Search - iis.sinica.edu.tw - cs.rpi.edu - iis.sinica.edu.tw - all 5 versions »

BASIC SCIENCE REVIEW
CAINS CELL - doi.wiley.com
... inac- tivated in a somatic cell, it is as if the cell has “lost its brakes.” Examples
of such tumor suppressor genes altered in SCCHN are TP53, RB1, and ...
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Epidermal growth factor and ionizing radiation up-regulate the DNA repair genes XRCC1 and ERCC1 in … - Full text - MIT Libraries
A Yacoub, R McKinstry, D Hinman, T Chung, P Dent, … - Radiat Res, 2003 - bioone.org
... unlike DU145 cells, LNCaP cells display wild-type RB and TP53 proteins and a ...
Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer ...
Cited by 10 - Web Search - apt.allenpress.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Genetically Targeted Cancer Therapy
SA Vorburger, A Pataer, SG Swisher, KK Hunt - Am J Pharmacogenomics, 2004 - ingentaconnect.com
... 1), p53, and signal transducer and activator of transcription (STAT)-1 and STAT3,
which have ... introduction of pro-apoptotic gene therapies with TP53, BAX, or ...
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Genetic predictors for drug resistance in soft tissue sarcoma: a review of publications in 2004.
J Fayette, JY Blay - Current Opinion in Oncology, 2005 - co-oncology.com
... 7••]. Its dysfunction may be caused by mutations of the TP53 gene as ... p42/44, AKT,
and S6K was KIT-dependent, whereas STAT1 and STAT3 phosphorylation was ...
Web Search - co-oncology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

From chemoprevention to chemotherapy: common targets and common goals
BB Aggarwal, Y Takada, OV Oommen - Expert Opinion on Investigational Drugs, 2004 - extenza-eps.com
... Constitutive activation of transcription factors • STAT3, AP-1, NF-κB • Tumour
suppressor genes Overexpression ... CBP β-catenin Nrf2 STAT3 STAT5 PPAR-γ p53 ...
Cited by 1 - Web Search - ashley-pub.com - dx.doi.org - ingentaconnect.com - all 8 versions »

Molecular mechanisms of drug resistance - Full text - MIT Libraries
DB Longley, PG Johnston - The Journal of Pathology, 2005 - doi.wiley.com
... So, 5-FU chemosen- sitivity may be dependent on the particular TP53 geno- type. ...
C3,7 p53 DcR3 EGFR Growth Factor STAT3/5 Akt BAD IAPs p21, GADD45 Growth Arrest ...
Cited by 4 - Web Search - ingentaconnect.com - uni-ulm.de - biochemie.uni-greifswald.de - all 5 versions »

5a-Androstane-3a, 17b-diol activates pathway that resembles the epidermal growth factor responsive …
RA Zimmerman, I Dozmorov, EH Nunlist, Y Tang, X Li … - Prostate Cancer and Prostatic Diseases, 2004 - nature.com
... Several genes’ expression patterns including PRKACB (M34181), PRKR1B (M65066), AR
(M20132), TP53 (M14694), and SRC (NM_005417) had different clustering ...
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SIAPEC IAP Societa Italiana International Academy di Anatomia Patologica e of Pathology …
B Board, GI di Immunoistochimica, GI di Patologia - springerlink.com
Page 1. 339 Page 2. SIAPEC IAP Società Italiana International Academy di Anatomia
Patologica e of Pathology Citopatologia Diagnostica Italian Division ...
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Journal of Carcinogenesis - Full text - MIT Libraries
MJ van Erk, E Teuling, YCM Staal, S Huybers, PJ … - Journal of Carcinogenesis, 2004 - bmc.ub.uni-potsdam.de
... involved in DNA repair, eg MLH1, MSH3 and ERCC2 (Tables 1 and 2). Upregulated signal
transduction genes included STAT3 and STAT5b (Table 1) and some genes of ...
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Time- and dose-dependent effects of curcumin on gene expression in human colon cancer cells - Full text - MIT Libraries
M van Erk, E Teuling, Y Staal, S Huybers, P van … - Journal of Carcinogenesis, 2004 - dx.doi.org
... Tables 1 and 2). Upregulated signal transduction genes included STAT3 and STAT5b ...
Curcumin downregulated expression of tumor protein p53 (TP53) (Figure 3), a ...
Cited by 2 - Web Search - pubmedcentral.nih.gov - carcinogenesis.com - citebase.eprints.org - all 9 versions »

Targeted therapy for epithelial ovarian cancer: Current status and future prospects
HT SEE, JJ KAVANAGH, W HU, RC BAST JR - Cancer, 2003 - ingentaconnect.com
... TP53 is the product of the oncogene p53 that activates the intrinsic apoptotic process
by regulating proteins BCL2 and BAX., which in turn activate the ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molecular Profiling of Inflammatory Breast Cancer - Full text - MIT Libraries
I Bieche, F Lerebours, S Tozlu, M Espie, M Marty, … - Clinical Cancer Research, 2004 - clincancerres.aacrjournals.org
... Bieche I, Bertheau P, et al Increased incidence of ERBB2 overexpression and TP53
mutation in ... D, Vellenga E, Kruijer W c-Jun and c-Fos cooperate with STAT3 in IL ...
Web Search - clincancerres.aacrjournals.org - ncbi.nlm.nih.gov

New genomic region for Wegener’s granulomatosis as revealed by an extended association screen with … - Full text - MIT Libraries
P Jagiello, M Gencik, L Arning, S Wieczorek, E … - Human Genetics, 2004 - springerlink.com
... NOX3 TNFRSF1B Casp4 IL4 SLPI NOX4 TNFRSF21 Casp5 IL4R STAT3 P2RX1 TNFRSF4 Casp6
IL6 TLR1 ... TP73 TNFSF7 RBQ-1 MADD a TAPBPR VDR TNFSF8 TP53 MAP2K6 ...
Cited by 6 - Web Search - peo.cshl.org - ncbi.nlm.nih.gov

MDA-7/IL-24 Regulates Proliferation, Invasion and Tumor Cell Radiosensitivity: A New Cancer Therapy? - Full text - MIT Libraries
P Dent, A Yacoub, S Grant, DT Curiel, PB Fisher - Journal of Cellular Biochemistry, 2005 - doi.wiley.com
... melanoma cells via an IL-20 receptor- dependent but STAT3-independent mechanism ...
radiosensitizes non-small cell lung cancer cells via TP53-independent mechanisms ...
Web Search - ncbi.nlm.nih.gov

DNA methylation in brain development and gliomagenesis
JF Costello - Front Biosci, 2003 - genetics.ucla.edu
... The differential methylation involves a critical STAT3 binding site,
preventing STAT3 binding and blocking GFAP expression (42). ...
Cited by 5 - View as HTML - Web Search - ncbi.nlm.nih.gov - bioscience.org - bioscience.org - all 6 versions » - Get it from MIT Libraries

NF2: The Wizardry of Merlin
G ASPECTS - GENES, CHROMOSOMES & CANCER, 2003 - doi.wiley.com
... RB1 and TP53 are often mutated in sporadic small-cell lung cancer, which is ... al.,
1999), and active Rac1 induces Stat3 activation by either direct binding of ...
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Abstracts of the 2nd International Symposium on Molecular Diagnostics and Skin Gene Therapy - Full text - MIT Libraries
I Session, II Session, IV Session, V Session, VI … - J Gene Med, 2003 - doi.wiley.com
... Therefore, we investigated the protein expression of Stat3 and Stat5 via Western
blot analysis and observed a constitutive level of these proteins in primary ...
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