protein GATAl - Full text - MIT Libraries
H OSADA, G GRUTZ, H AXELSON, A FORSTER, TH … - Proc. Natl. Acad. Sci. USA, 1995 - pnas.org
... involving RBTN2, TAL1, and GATA1, together with E47, the basic helix-loop-helix
heterodimerization partner of TAL1, could be demonstrated. ...
Cited by 85 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

TAL 1 expression does not occur in the majority of T-ALL blasts - Full text - MIT Libraries
E Delabesse, M Bernard, VE Meyer, L Smit, K … - British Journal of Haematology, 1998 - blackwell-synergy.com
... Comparative sensitivity of detection of TAL1 and GATA1 transcripts was assessed
by log dilution of K562 RNA in HPB-ALL RNA prior to reverse transcription and ...
Cited by 13 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Transcriptional activity of TAL 1 in T cell acute lymphoblastic leukemia(T-ALL) requires RBTN 1 or-2 … - Full text - MIT Libraries
Y Ono, N Fukuhara, O Yoshie - J Biol Chem, 1997 - jbc.org
... TAL1 and GATA2. On the other hand, they observed little significant binding
between TAL1 and GATA1 or GATA2 (24). These results ...
Cited by 18 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Expression profiling of CD34 hematopoietic stem/progenitor cells reveals distinct subtypes of … - Full text - MIT Libraries
Z Qian, AA Fernald, LA Godley, RA Larson, MM Le … - N. Engl. J. Med, 2005 - dx.doi.org
... A second subgroup of t-AML is characterized by down-regulation of transcription
factors involved in early hematopoiesis (TAL1, GATA1, and EKLF) and ...
Cited by 21 - Web Search - pnas.org - pubmedcentral.nih.gov - fgf.bsd.uchicago.edu - all 7 versions »

The GATA-E box-GATA motif in the EKLF promoter is required for in vivo expression - Full text - MIT Libraries
KP Anderson, SC Crable, JB Lingrel - Blood, 2000 - bloodjournal.org
... The identification of a multiprotein complex in which Lmo2 acts as a bridge between
Tal1 and GATA1 has been identified in erythroid cells, 21-25 which might ...
Cited by 8 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Lmo 2 and Scl/Tal 1 convert non-axial mesoderm into haemangioblasts which differentiate into … - Full text - MIT Libraries
M Gering, Y Yamada, TH Rabbitts, RK Patient - Development, 2003 - dev.biologists.org
... This restriction correlates well with activation of gata1 transcription and
co-injection of gata1 mRNA along with scl/tal1 and lmo2 induces erythropoiesis more ...
Cited by 10 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell … - Full text - MIT Libraries
Y Ono, N Fukuhara, O Yoshie - Mol. Cell. Biol, 1998 - mcb.asm.org
... element(s). The TAL1-LMO-GATA3 complex in T-ALL may contain Ldb1 (also called NL1
or CLIM2) (1, 3, 25), like the TAL1-LMO2-GATA1 complex in erythroid cells (60 ...
Cited by 39 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

HbF reactivation in sibling BFU-E colonies: synergistic interaction of kit ligand with low-dose … - Full text - MIT Libraries
M Gabbianelli, U Testa, A Massa, O Morsilli, E … - Blood, 2003 - bloodjournal.org
... 28 Id2, Tal1, and GATA1 expression. Id2 ... Tal1 and GATA1, though undetectable
in HPCs, are induced in erythroid culture. Specifically ...
Cited by 3 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

The LIM Protein RBTN2 and the Basic Helix-Loop-Helix Protein TAL1 are Present in a Complex in … - Full text - MIT Libraries
VE Valge-Archer, H Osada, AJ Warren, A Forster, J … - Proceedings of the National Academy of Sciences - pnas.org
... and RK Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts
which differentiate into endothelial cells in the absence of Gata1 Development ...
Cited by 93 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Therapy-related myeloid leukaemia: A model for leukemogenesis in humans.
RA Larson, MM Le Beau - Chem Biol Interact, 2005 - ncbi.nlm.nih.gov
... A second subgroup of t-AML is characterized by down-regulation of transcription
factors involved in early hematopoiesis (TAL1, GATA1, and EKLF) and ...
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Positive and Negative Transcriptional Control by the TAL1 Helix-Loop-Helix Protein - Full text - MIT Libraries
H Hsu, I Wadman, JT Tsan, R Baer - Proceedings of the National Academy of Sciences - pnas.org
... and RK Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts
which differentiate into endothelial cells in the absence of Gata1 Development ...
Cited by 34 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Hematopoietic differentiation of human embryonic stem cells progresses through sequential … - Full text - MIT Libraries
ET Zambidis, B Peault, TS Park, F Bunz, CI Civin - Blood, 2005 - bloodjournal.org
... Gene expression analysis of differentiating hEBs revealed that initiation of
hematopoiesis correlated with increased levels of SCL/TAL1, GATA1, GATA2, CD34 ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Uroporphyrinogen III synthase erythroid promoter mutations in adjacent GATA1 and CP2 elements cause … - Full text - MIT Libraries
C Solis, GI Aizencang, KH Astrin, DF Bishop, RJ … - J Clin Invest, 2001 - jci.org
... of GATA1 and CP2 in the promoter complex and the association of CP2 with
transcriptional factors known to form complexes with GATA1, including FOG and TAL1/ ...
Cited by 10 - Web Search - jci.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Helix-loop-helix(E 2-5, HEB, TAL 1 and Id 1) protein interaction with the TCRalphadelta enhancers - Full text - MIT Libraries
M Bernard, E Delabesse, L Smit, C Millien, IR … - International Immunology, 1998 - intimm.oupjournals.org
... 1998 Oxford University Press Helix-loop-helix (E2-5, HEB, TAL1 and Id1) ... TCR
[αE1-2] activity was partially (40%) inhibited by TAL1 but not at all by Id1. ...
Cited by 6 - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Promoter 1 of LMO2, a master gene for hematopoiesis, is regulated by the erythroid specific …
HH Anthropology, M Genetics, G Berlin - Gene Funct. Dis, 2000 - doi.wiley.com
... [11], which is a binding site for a DNA binding complex including TAL1,
E47, GATA1, LDB1/NL1 and LMO2 found in erythroid cells. ...
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Tie2Cre-mediated gene ablation defines the stem-cell leukemia gene (SCL/tal1)–dependent window … - Full text - MIT Libraries
TM Schlaeger, HK Mikkola, C Gekas, HB Helgadottir, … - Blood, 2005 - bloodjournal.org
... on the basic helix-loop-helix (bHLH) transcription factor/T-cell oncogene SCL/tal1. ...
LIM only protein 2 (LMO2) and GATA binding factor 1 (GATA1), SCL induces ...
Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

Hematopoietic regulatory domain of gata1 gene is positively regulated by GATA1 protein in zebrafish … - Full text - MIT Libraries
M Kobayashi, K Nishikawa, M Yamamoto - Development, 2001 - dev.biologists.org
Hematopoietic regulatory domain of gata1 gene is positively regulated by GATA1 protein
in zebrafish embryos. ... (A) Structure of the zebrafish gata1 gene. ...
Cited by 17 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Differences in the chromatin structure and cis-element organization of the human and mouse GATA1 … - Full text - MIT Libraries
V Valverde-Garduno, B Guyot, E Anguita, I Hamlett, … - Blood, 2004 - bloodjournal.org
... GATA2 have been implicated in promoting GATA1 expression 16,49 ) and E-boxes that
can bind the hematopoietic transcription factor SCL/Tal1 (hereafter referred ...
Cited by 3 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 … - Full text - MIT Libraries
Z Xu, S Huang, LS Chang, AD Agulnick, SJ Brandt - Mol Cell Biol, 2003 - pubmedcentral.nih.gov
... Identification of a TAL1 Target Gene Reveals a Positive Role for the LIM
Domain-Binding Protein Ldb1 in Erythroid Gene Expression and Differentiation. ...
Cited by 9 - Web Search - dx.doi.org - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter … - Full text - MIT Libraries
TH Rabbitts - Genes Dev, 1998 - genesdev.org
... The ability of the Lmo2 protein to interact with Tal1 and with GATA1 appears to
facilitate the formation of a complex in which two DNA contacting regions ...
Cited by 50 - Web Search - genesdev.org - ncbi.nlm.nih.gov

Progress in Hematology
Y Hayashi - cardenjennings.metapress.com
... subgroup of therapy-related leukemia is characterized by down- regulation of
transcription factors involved in early hemato- poiesis (TAL1, GATA1, and EKLF ...
Web Search

GATA1 Function, a Paradigm for Transcription Factors in Hematopoiesis - Full text - MIT Libraries
R Ferreira, K Ohneda, M Yamamoto, S Philipsen - Mol Cell Biol, 2005 - mcb.asm.org
... All Rights Reserved. MINIREVIEW. GATA1 Function, a Paradigm for Transcription
Factors in Hematopoiesis. ... GATA1: A BIRD IN THE HAND. ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

ROLE OF THE TAL1/SCL TRANSCRIPTION FACTOR IN NORMAL AND LEUKEMIC HEMATOPOIESIS
SJ BRANDT - doi.wiley.com
Page 1. CHAPTER 4 ROLE OF THE TAL1/SCL TRANSCRIPTION ... Translocations 3 to the TAL1
locus, in some cases a considerable distance, have also been ...
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Transcriptional control of fetal liver hematopoiesis: dominant negative effect of the overexpression …
T Terano, Y Zhong, S Toyokuni, H Hiai, Y Yamada - Exp Hematol, 2005 - ncbi.nlm.nih.gov
... The LIM-finger protein LMO2 forms a transcription factor complex with other
hematopoietic regulator proteins, such as TAL1 (SCL), LDB1, GATA1, 2, and 3, in ...
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The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis - Full text - MIT Libraries
Y Yamada, AJ Warren, C Dobson, A Forster, R … - Physiol Genomics, 2004 - dx.doi.org
... and RK Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts
which differentiate into endothelial cells in the absence of Gata1 Development ...
Cited by 78 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, … - Full text - MIT Libraries
MA Hall, DJ Curtis, D Metcalf, AG Elefanty, K … - Blood, 2004 - dx.doi.org
... and RK Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts
which differentiate into endothelial cells in the absence of Gata1 Development ...
Cited by 21 - Web Search - pnas.org - intl.pnas.org - pubmedcentral.nih.gov - all 7 versions »

Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem … - Full text - MIT Libraries
S Gerecht-Nir, JE Dazard, M Golan-Mashiach, S … - Developmental Dynamics, 2005 - doi.wiley.com
... 2003), CD45 (Mikkola et al., 2003; Ferkowicz et al., 2003), and transcrip- tion
factors TAL1, LMO2, GATA1, GATA2, and GATA3, although up-reg- ulation of the ...
Cited by 2 - Web Search - weizmann.ac.il - weizmann.ac.il - ncbi.nlm.nih.gov

LMO3 Interacts with Neuronal Transcription Factor, HEN2, and Acts as an Oncogene in Neuroblastoma - Full text - MIT Libraries
M Aoyama, T Ozaki, H Inuzuka, D Tomotsune, J … - Cancer Research, 2005 - cancerres.aacrjournals.org
... 39). On the other hand, a stable complex comprising LMO2, TAL1, and GATA1
was required to promote erythroid differentiation (32). ...
Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei - Full text - MIT Libraries
JH van Doorninck, J van der Wees, A Karis, E … - J. Neurosci, 1999 - jneurosci.org
... A, Rabbitts TH (1997) The LIM-only protein Lmo2 is a bridging molecule assembling
an erythroid, DNA-binding complex which includes the TAL1, E47, GATA1 and Ldb1 ...
Cited by 29 - Web Search - jneurosci.org - ncbi.nlm.nih.gov

Intraembryonic Hematopoietic Cell Migration During Vertebrate Development - Full text - MIT Libraries
IIID HW, MW Kieran, FY Chan, LM Barone, K Yee, JA … - Proceedings of the National Academy of Sciences - pnas.org
... and RK Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts
which differentiate into endothelial cells in the absence of Gata1 Development ...
Web Search

Hemoglobins from bacteria to man: evolution of different patterns of gene expression - Full text - MIT Libraries
R Hardison - J. Exp. Biol, 1998 - jeb.biologists.org
... distal to the genes. Examples include a potential target for the hematopoietic
transcription factor TAL1. Key words: hemoglobin, evolution ...
Cited by 78 - Web Search - jeb.biologists.org - 163.238.8.180 - ncbi.nlm.nih.gov - all 5 versions »

Functional Analysis of Human Hematopoietic Stem Cell Gene Expression Using Zebrafish - Full text - MIT Libraries
CE Eckfeldt, EM Mendenhall, CM Flynn, TF Wang, MA … - PLoS Biol, 2005 - medicine.plosjournals.org
... signaling) and commitment (vascular endothelial growth factor signaling; flk1, also
known as kdr; lmo2; scl, also known as tal1; gata2; gata1) are conserved ...
Cached - Web Search - plme.allenpress.com - biology.plosjournals.org - pubmedcentral.nih.gov

SCL interacts with VEGF to suppress apoptosis at the onset of hematopoiesis - Full text - MIT Libraries
R Martin, R Lahlil, A Damert, L Miquerol, A Nagy, … - Development, 2004 - dev.biologists.org
... on VEGF/Flk1 signaling and on the function of the SCL/Tal1 transcription factor ... survival
of erythroid cells and the expression of erythroid genes (Gata1 and ßH1 ...
Cited by 5 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Leukaemia- a developmental perspective - Full text - MIT Libraries
S Izraeli - British Journal of Haematology, 2004 - blackwell-synergy.com
... development will be described through the examination of the developmental and the
leukaemogenic roles of three genes - RUNX1 (AML1), GATA1, and SCL (TAL1). ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Expression of alpha4-integrin defines the earliest precursor of hematopoietic cell lineage diverged … - Full text - MIT Libraries
M Ogawa, M Kizumoto, S Nishikawa, T Fujimoto, H … - Blood, 1999 - bloodjournal.org
... Different dilutions of cDNA prepared from sorted cells were subjected to PCR
amplification specific for Gata1, Gata2, Tal1, Lmo2, Myb, and Gapd transcripts. ...
Cited by 35 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

BMC Developmental Biology - Full text - MIT Libraries
JM Woda, T Calzonetti, MP Duyao, RA Conlon, ME … - BMC Developmental Biology, 2005 - biomedcentral.com
... or vasculogenesis (Ttr, Rbp,Flt1,Flk1,Tal1,Rbtn2,GATA1) (data not
shown),suggesting that huntingtinis not essential for the proper ...
View as HTML - Web Search

acquises de la cellule souche hematopoietique ou d’un precurseur deja commis vers les lignees …
S YNTHESE - MEDECINE/SCIENCES, 2003 - ist.inserm.fr
... à la surexpression de facteurs de transcription de type bHLH (LYL1 et TAL1) ou de
pro ... Ces leucémies présentent des mutations ponctuelles du gène GATA1. ...
View as HTML - Web Search - erudit.org

Uroporphyrinogen III Synthase - Full text - MIT Libraries
GI Aizencang, DF Bishop, D Forrest, KH Astrin, RJ … - J Biol Chem, 2000 - jbc.org
... E47 has been shown to be a DNA binding partner of GATA1 and Tal1 in the formation
of a transcriptional transactivating complex in erythroid cells (47) and may ...
Cited by 16 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Characterization of the Lmo 4 gene encoding a LIM-only protein: genomic organization and comparative … - Full text - MIT Libraries
E Tse, G Grutz, AA Garner, Y Ramsey, NP Carter, N … - Mammalian Genome, 1999 - springerlink.com
... 1998), apparently by involvement in multimeric protein complexes with transcription
factors TAL1, E47, GATA1, and LDB1 (Valge- Archer et al. ...
Cited by 9 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

In Silico Identification of Regulatory Elements of GRIN 1 Genes
MK Mejia-Guerra, LR Lareo - Omics A Journal of Integrative Biology, 2005 - dx.doi.org
... 0 to 100 Bsap NF-Y NF-Y 100 to 200 Tal1 - Tal1 - Tal1 - 47S, 47S 47S, CFI-USP
CFI-USP ... (2 copies) HNF-3b (2 copies) 700 to 600 GATA1, GATAX, CdxA SRY Mkx-2 ...
Web Search - liebertonline.com - liebertonline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Analysis of the relationship between Scl transcription factor complex protein expression patterns …
AM Rice, KM Holtz, J Karp, S Rollins, AC … - Leuk Res, 2004 - ncbi.nlm.nih.gov
... Exogenous expression of the transcription factor Scl (Tal1) in WEHI-3B D+ ... Levels
of Scl, Rbtn2, GATA1, and Ldb1 expression were comparable in AML and APL blasts ...
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Oncogenes et leucemies: historique et perspectives
S Gisselbrecht, BG Roussy - M e decine et Science, 2003 - erudit.org
... à la surexpression de facteurs de transcription de type bHLH (LYL1 et TAL1) ou de ...
Ces leucémies présentent des mutations ponctuelles du gène GATA1. ...
Cited by 2 - Cached - Web Search

Conserved E Boxes Function as Part of the Enhancer in Hypersensitive Site 2 of the beta-Globin Locus … - Full text - MIT Libraries
L Elnitski, W Miller, R Hardison - J. Biol. Chem, 2004 - jbc.org
... RBTN2, which is essential for erythropoiesis, forms a complex with TAL1 in erythroid
cells (65). Interestingly, RBTN2 also forms complexes with GATA1 (34), and ...
Cited by 33 - Web Search - jbc.org - ncbi.nlm.nih.gov

Oligo GEArray® Human Hematopoietic Stem Cells and Hematopoiesis Microarray
S Conditions - search.cosmobio.co.jp
... BCL11A, CBFB, CD80, CD86, CEBPE, CEBPG, EGR1, ETS1, ETV6, GATA1, GATA2, GFI1 ... NOTCH4,
PAX5, RBPSUH, RHOH, RUNX1, SCAND1, STAT1, STAT3, STAT4, TAL1, VAV1, WWP1 ...
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Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells - Full text - MIT Libraries
H Ohta, A Sawada, JY Kim, S Tokimasa, S Nishiguchi … - J Exp Med, 2002 - jem.org
... gp130, Epo receptor, G-CSF receptor, GM-CSF receptor, c-erbA , c-Mpl, c-jun, c-fos,
c-myc, c-myb, tal1/SCL, AML1, GATA1, GATA2, and PU.1. Expression of none of ...
Cited by 29 - Web Search - intl.jem.org - ncbi.nlm.nih.gov

zPicture: Dynamic Alignment and Visualization Tool for Analyzing Conservation Profiles - Full text - MIT Libraries
I Ovcharenko, GG Loots, RC Hardison, W Miller, L … - Genome Research, 2004 - genome.org
... Alignments were analyzed for the presence of GATA1, NFE2, and Tal1 putative
transcription factor-binding sites (TFBS). Clusters ...
Cited by 17 - Web Search - ivan.dcode.org - gel.ym.edu.tw - bio.cse.psu.edu - all 12 versions »

Absence of Yolk sac Hematopoiesis from Mice with a Targeted Disruption of the scl Gene - Full text - MIT Libraries
L Robb, I Lyons, R Li, L Hartley, F Kontgen, RP … - Proceedings of the National Academy of Sciences - pnas.org
... and RK Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts
which differentiate into endothelial cells in the absence of Gata1 Development ...
Cited by 181 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - adsabs.harvard.edu

Functional ablation of the mouse Ldb 1 gene results in severe patterning defects during gastrulation - Full text - MIT Libraries
M Mukhopadhyay, A Teufel, T Yamashita, AD Agulnick … - Development, 2003 - dev.biologists.org
... differentiation (Winnier, 1995). Ldb1 can form a transcriptional complex
with Lmo2, Tal1, Gata1 and E47. Functional ablation of ...
Cited by 13 - Web Search - codon.ciencias.uchile.cl - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Haemangioblast commitment is initiated in the primitive streak of the mouse embryo - Full text - MIT Libraries
TL Huber, V Kouskoff, H Joerg Fehling, J Palis, G … - Nature, 2004 - nature.com
... associated with haematopoietic and vascular development including Flk-1 (refs 3,
4–5), Scl 6, 7 (also known as Tal1), VE-cadherin 8 (Cdh5), Gata1 (refs 7, 9 ...
Cited by 11 - Web Search - nature.com - ncbi.nlm.nih.gov

Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during … - Full text - MIT Libraries
DA Kenny, LW Jurata, Y Saga, GN Gill - Developmental Biology, 1998 - dx.doi.org
... and RK Patient Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts
which differentiate into endothelial cells in the absence of Gata1 Development ...
Cited by 36 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »