Association of a novel GTP binding protein, DRG, with TAL oncogenic proteins
MA Mahajan, ST Park, XH Sun - Oncogene, 1996 - ncbi.nlm.nih.gov
... Furthermore, while DRG and E47 compete to interact with TAL1, TAL1 binds to ...
transformation assays, DRG stimulated the cotransforming activity of c-myc and ras. ...
Cited by 22 - Web Search - Get it from MIT Libraries

The Tal1 oncoprotein inhibits E47-mediated transcription - Full text - MIT Libraries
ST Park, XH Sun - J Biol Chem, 1998 - jbc.org
... could detect all of the fusion proteins, Western analyses were performed using the
same blot or cell lysates with antibodies against Tal1, the myc tag (9E10 ...
Cited by 33 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Phosphorylation of the TAL1 oncoprotein by the extracellular-signal-regulated protein kinase ERK1 - Full text - MIT Libraries
JT Cheng, MH Cobb, R Baer - Mol Cell Biol, 1993 - pubmedcentral.nih.gov
... site located in the NH2-terminal domain of c-Myc increases transactivation ... leukemia:
chromosome breakage 25 kilobase pairs downstream of the TAL1 protooncogene ...
Cited by 33 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov

Transcriptional activation by TAL1 and FUS-CHOP proteins expressed in acute malignancies as a result … - Full text - MIT Libraries
I Sanchez-Garcia, TH Rabbitts - Proc Natl Acad Sci US A, 1994 - pubmedcentral.nih.gov
... [ Free Full text in PMC]; Cheng JT, Hsu HL, Hwang LY, Baer R. Products of the TAL1
oncogene: basic helix-loop-helix proteins ... myc function and regulation. ...
Cited by 38 - Web Search - pnas.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute …
R Baer - Semin. Cancer Biol, 1993 - ncbi.nlm.nih.gov
... Thus, TAL1, TAL2 and LYL1 constitute a unique family of bHLH proteins, each of ... Gene
Rearrangement, T-Lymphocyte*; Genes, myc; Helix-Loop-Helix Motifs/physiology* ...
Cited by 43 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Akt Phosphorylates Tal1 Oncoprotein and Inhibits Its Repressor Activity - Full text - MIT Libraries
A Palamarchuk, A Efanov, V Maximov, RI Aqeilan, CM … - Cancer Research, 2005 - cancerres.aacrjournals.org
... To prove this interaction, we cotransfected 293 cells with AKT-Myc and TAL1-HA or
TAL1(T90A)-HA and carried out coimmunoprecipitation experiments using anti-HA ...
Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

The Tal1 Oncoprotein Inhibits E47-mediated Transcription - Full text - MIT Libraries
MOF INHIBITION - J Biol Chem, 1998 - jbc.org
... could detect all of the fusion proteins, Western analyses were performed using the
same blot or cell lysates with antibodies against Tal1, the myc tag (9E10 ...
Web Search - jbc.org

The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice - Full text - MIT Libraries
O Terradillos, O Billet, CA Renard, R Levy, T … - Oncogene, 1997 - nature.com
... potential of di€erent cellular and viral genes, like cyclin D1, Tal1 and the ... the
present ®nding that combined expression of the HBX and c-myc genes produced ...
Cited by 76 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Cre/lox-regulated transgenic zebrafish model with conditional myc-induced T cell acute lymphoblastic … - Full text - MIT Libraries
DM Langenau, H Feng, S Berghmans, JP Kanki, JL … - Proceedings of the National Academy of Sciences, 2005 - pnas.org
... 2 B-E) showed that all Myc-induced leukemias coexpress tal1/scl and lmo2 (n = 20)
but not lmo1, hox11, or the zebrafish orthologues of HOX11L2/TLX3, tlx3a, or ...
Web Search - dx.doi.org - pnas.org - ncbi.nlm.nih.gov

Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia - Full text - MIT Libraries
I Wadman, J Li, RO Bash, A Forster, H Osada, TH … - Mol. Cell. Biol, 2004 - embojournal.npgjournals.com
... in that RBTN1 and RBTN2 will associate with TAL1, TAL2 and LYL1, but not with other
bHLH proteins, including E12, E47, Id1, NHLH1, AP4, MAX, MYC and MyoD1. ...
Cited by 99 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell … - Full text - MIT Libraries
Y Ono, N Fukuhara, O Yoshie - Mol. Cell. Biol, 1998 - mcb.asm.org
... TAL1 and LIM-Only Proteins Synergistically Induce Retinaldehyde Dehydrogenase 2
Expression in T-Cell Acute Lymphoblastic Leukemia by Acting as Cofactors for ...
Cited by 39 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

mSin3A regulates murine erythroleukemia cell differentiation through association with the TAL1 (or … - Full text - MIT Libraries
S Huang, SJ Brandt - Mol Cell Biol, 2000 - mcb.asm.org
... and developmental role of Id2 protein and TAL1/E2A heterodimer in ... Constitutive
c-myc oncogene expression blocks mouse erythroleukaemia cell differentiation but ...
Cited by 18 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

ROLE OF THE TAL1/SCL TRANSCRIPTION FACTOR IN NORMAL AND LEUKEMIC HEMATOPOIESIS
SJ BRANDT - doi.wiley.com
... in CD34> cells was dependent on binding sites for the myc-asso- ciated ... activity of
both of these promoters when stably introduced into TAL1- expressing cells ...
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TAL2, a helix-loop-helix gene activated by the (7; 9)(q34; q32) translocation in human T-cell … - Full text - MIT Libraries
Y Xia, L Brown, CY Yang, JT Tsan, MJ Siciliano, R … - Proc Natl Acad Sci US A, 1991 - pubmedcentral.nih.gov
... Hence, TAL2, TAL1, and LYL1 constitute a discrete subgroup of helix-loop-helix ... motif
in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. ...
Cited by 43 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Cytogenetics and molecular genetics of childhood leukemia
SK Ma, TSK Wan, LC Chan - Hematological Oncology, 1999 - doi.wiley.com
... t(8;22)(q24;q11) myc-IgL B (mature) <1 t(2;8)(p12;q24) myc-IgK B (mature) <1
t(1;14)(p32;q11) TAL1-TCRd T <1 t(1;7)(p32;q34) TAL1-TCRb T <1 t(1;7)(p34;q34) LCK ...
Cited by 15 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

DETECTION OF MINIMAL RESIDUAL DISEASE IN ACUTE LEUKEMIA
C Karyotyping, CC Techniques - ishapd.org
... TAL TAL-SIL 5-7 4 t(8;14)(q24;q11) MYC (TCRD)< 1 < 1 ... t(11;14)(p13;q11) TTG2 (TCRD)
1 1 t(1;7)(p32;q35) TAL1 (TCRB) < 1 < 1 t(1;14)(p32;q11) TAL1 (TCRD) 1 < 1 ...
View as HTML - Web Search - haem.nus.edu.sg

Molecular mechanisms of hematologic malignancies
JJ Yunis, J Tanzer - Crit Rev Oncog, 1993 - ncbi.nlm.nih.gov
... Genetics). Gene Symbols: ABL; AML1; BCR; C-myc; CAN; DEK; E2A; FMS; HOX11; LYL 1;
LYL1; MLL; MYC; P53; RARA; RAS; SCL; TAL1; TAL2; TAN1; TAN2; TCL5; bcl-1; bcl- ...
Cited by 4 - Web Search - Get it from MIT Libraries

HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are coexpressed in a human … - Full text - MIT Libraries
L Brown, R Espinosa 3rd, MM Le Beau, MJ Siciliano, … - Proc Natl Acad Sci US A, 1992 - pubmedcentral.nih.gov
... HEN1 gene was identified on the basis of cross-hybridization with TAL1, a known ... motif
in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. ...
Cited by 18 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor … - Full text - MIT Libraries
S Huang, Y Qiu, Y Shi, Z Xu, SJ Brandt - The EMBO Journal, 2000 - embojournal.npgjournals.com
... (B) HeLa cells were transfected with expression vectors for Myc-tagged TAL1 bHLH
polypeptide (Myc-Tal1 bHLH ) or Flag-tagged P/CAF (Flag-P/CAF), cellular ...
Cited by 22 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 7 versions »

HEN1 encodes a 20-kilodalton phosphoprotein that binds an extended E-box motif as a homodimer - Full text - MIT Libraries
L Brown, R Baer - Mol. Cell. Biol, 1994 - pubmedcentral.nih.gov
... [PubMed]; Cheng JT, Hsu HL, Hwang LY, Baer R. Products of the TAL1 oncogene: basic ...
between related DNA sites by a single amino acid residue of Myc-related basic ...
Cited by 15 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The Gene SCL is Expressed during Early Hematopoiesis and Encodes a Differentiation-Related DNA- … - Full text - MIT Libraries
CG Begley, PD Aplan, SM Denning, BF Haynes, TA … - Blood, 2005 - pnas.org
... Home page ST Park and XH Sun The Tal1 Oncoprotein Inhibits E47-mediated Transcription ...
7 homeobox gene causes decreased expression of GATA-1 and c-myc genes and ...
Cited by 116 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Functional overlap of sequences that activate transcription and signal ubiquitin-mediated … - Full text - MIT Libraries
SE Salghetti, M Muratani, H Wijnen, B Futcher, WP … - Biochemistry, 2000 - dx.doi.org
... and K. I Nakayama Phosphorylation-dependent degradation of c-Myc is mediated ... Protein
Kinase Mediates the Hypoxia-induced Turnover of the TAL1/SCL Transcription ...
Cited by 93 - Web Search - pnas.org - pubmedcentral.nih.gov - tanseylab.cshl.edu - all 7 versions »

Oligo GEArray® Human Hematopoietic Stem Cells and Hematopoiesis Microarray
S Conditions - search.cosmobio.co.jp
... IFI16, IL31RA, IRF4, IRF8, KLF6, LEF1, MAFB, MYC, NCOA6, NFYA, NOTCH1, NOTCH2, NOTCH4,
PAX5, RBPSUH, RHOH, RUNX1, SCAND1, STAT1, STAT3, STAT4, TAL1, VAV1, WWP1 ...
View as HTML - Web Search

Full Article
MD Jian-Tao Yang, MD Cheng-Zheng Liu, P Domer, MD … - Cancer Detection and Prevention, 1998 - blackwell-synergy.com
... with abundant c-myc expression and not in T-cell lymphomas lacking c-myc, suggesting
cooperation between Pim-1 and c-myc in T-cell lymphomagenesis. Tal1/SCL-1 ...
Web Search

Non-Hodgkin’s lymphoma in childhood - Full text - MIT Libraries
JT Sandlund, JR Downing, WM Crist - N Engl J Med, 1996 - ishapd.org
... 28 T-cell§ Mediastinum or head and neck t(1;14)(p32;q11) TCRαδ - TAL1 t(11;14 ... TCRαδ -
HOX11 t(7;19)(q35;p13) TCRβ - LYL1 t(8;14)(q24;q11) TCRαδ - MYC t(1 ...
Cited by 66 - View as HTML - Web Search - haem.nus.edu.sg - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Overexpression of DRG 2 Increases G 2/M Phase Cells and Decreases Sensitivity to Nocodazole-Induced … - Full text - MIT Libraries
H Song, SI Kim, MS Ko, HJ Kim, JC Heo, HJ Lee, HS … - Journal of Biochemistry, 2004 - jb.oxfordjournals.org
... tissue development (12, 13), the association of DRGs with SCL/TAL1 could be an ... of
DRG1 triggered cell transformation in fibroblasts with c-myc and ras. ...
Cited by 1 - Web Search - jb.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Phosphorylation by Mitogen-activated Protein Kinase Mediates the Hypoxia-induced Turnover of the TAL … - Full text - MIT Libraries
T Tang, JL Arbiser, SJ Brandt - J Biol Chem, 2002 - jbc.org
... To express Myc epitope-tagged Tal1 and Tal1 S122A proteins, the appropriate cDNA
was subcloned into vector pcDNA3.1( ) (Invitrogen), and a nucleotide sequence ...
Cited by 6 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

[CITATION] REVIEW ARTICLES
JT Sandlund, JR Downing, WM Crist - THE NEW ENGLAND JOURNAL OF MEDICINE, 1996
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Molekulare Diagnostik bei Leukaemien
E eine zentrale Rolle - studentenservice.novartis.de
... t(9;22) abl; bcr bcr-abl ALL/CML t(8;14) c-myc; igh c-myc B-ALL t(8;22) c-myc; IGλ
c-myc B-ALL t(1;14) tal1; tcrα tal1 T-ALL Translokation Deletion Trisomie ...
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Recurrent chromosomal translocations and fusion genes in leukemia-lymphoma cell lines
HG Drexler, RAF MacLeod, A Borkhardt, JWG Janssen - Leukemia, 1995 - ncbi.nlm.nih.gov
... Cultured. Gene Symbols: ALK; AML-1; BCL1; BCL2; BCL6; BLC3; E2A; EAP; EVI1; HOX11;
IL3; LCK; LYL1; LYT10; MDS; MTCP1; MYC; PBX1; RCK; SIS; TAL1; TAL2; TAN1; TTG11 ...
Cited by 40 - Web Search - Get it from MIT Libraries

Involvement of the small GTPase rho in integrin-mediated activation of mitogen-activated protein … - Full text - MIT Libraries
MW Renshaw, D Toksoz, MA Schwartz - J Biol Chem, 1996 - jbc.org
... Substrates for MAP kinases include many transcription factors, such as TCF, Jun,
Fos, Myc, NF-IL6, TAL1, and ATF2 (8, 9). MAP kinases are also involved in ...
Cited by 83 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Chromosomal Abnormalities, Cancer and Mouse Models: The Critical Role of Translocation-Associated …
WIS CANCER, IOF ONCOGENES - Current Genomics, 2000 - ingentaconnect.com
... bc12-Eµ SWR/Jx SLJ/J Polyclonal expansion of B-cells WAP-bc12-SV40pA
C57BL/6 Increased MMTV-myc-induced tumours ... CD2-TAL1 ---- Normal ...
Web Search

The t (14; 21)(q 11. 2; q 22) chromosomal translocation associated with T-cell acute lymphoblastic … - Full text - MIT Libraries
J Wang, SN Jani-Sait, EA Escalon, AJ Carroll, PJ … - Proceedings of the National Academy of Sciences, 2000 - pnas.org
... T-ALL typically activate protooncogenes, most commonly through juxtaposition of
TCR regulatory elements (1, 2). Several of the genes (MYC, SCL/TAL1, LYL1, and ...
Cited by 19 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

ERK 3 is a constitutively nuclear protein kinase. - Full text - MIT Libraries
M Cheng, TG Boulton, MH Cobb - J Biol Chem, 1996 - jbc.org
... Myc-ERK3 and Myc-ERK3 Ct are indicated ... none of these candidate substrates, including
myelin basic protein, microtubule-associated protein-2, c-Jun, Tal1, MyoD, c ...
Cited by 44 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

HOX11L2 expression defines a clinical subtype of pediatricT-ALLassociated with poor prognosis - Full text - MIT Libraries
LMO LYL - Blood, 2002 - bloodjournal.org
... showed t(8;14)(q24;q11), expected to lead to transcriptional activation of the
c-MYC gene. 21 No cytogenetic abnormality of the LYL1(19p13), TAL1 (1p32), or ...
Cited by 21 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Identification of a RING protein that can interact in vivo with the BRCA 1 gene product
LC Wu, ZW Wang, JT Tsan, MA Spillman, A Phung, XL … - Nature Genetics, 1996 - nature.com
... Intracellular leucine zipper interactions suggest c-Myc hetero-oligomerization ... HL,
Wadman, I. & Baer, R. Formation of in vivo complexes between the TAL1 and E2A ...
Cited by 209 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Chromosomal abnormalities and tumor development: from genes to therapeutic mechanisms - Full text - MIT Libraries
C Cobaleda, J Perez-Losada, I Sanchez-Garcia - BioEssays, 1998 - doi.wiley.com
... DNA. (9) These include basic helix-loop-helix (bHLH) proteins such as
TAL1/SCL in T-ALL or c-MYC in Burkitt’s lymphoma (BL). The ...
Cited by 13 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Suppression of Erythroid but Not Megakaryocytic Differentiation of Human K 562 Erythroleukemic Cells … - Full text - MIT Libraries
LT Lam, C Ronchini, J Norton, AJ Capobianco, EH … - J Biol Chem, 2000 - jbc.org
... The TAL1 antibody was incubated with the membrane for 12 h at 4 °C, and ... To detect
stably expressed Myc-tagged NIC-1 (NIC-1-myc), whole cell lysates were ...
Cited by 30 - Web Search - jbc.org - dx.doi.org - ncbi.nlm.nih.gov

Common sequence in chromosome translocations affecting B-and T-cell malignancies: a novel …
P Seite, J Hillion, D Leroux, R Berger, CJ Larsen - Genes Chromosomes Cancer, 1993 - ncbi.nlm.nih.gov
... Gene Symbols: IG; IGL; MYC/PVT1; TAL1; TCR; TCRG/D. Substances: DNA
Nucleotidyltransferases; VDJ Recombinases. PMID: 7685632 [PubMed - indexed for MEDLINE]
Cited by 1 - Web Search - Get it from MIT Libraries

Response to Letter to Editor by Bernard et al
OH Cleveland - bloodjournal.org
... bHLH proteins such as MyoD and c-Myc, in which multiple NLS are Our original report
on SCL ... as an NLS-not to map out all the potential NLS in SCL/TAL1.4 However ...
Web Search

Cdkn2a, the cyclin-dependent kinase inhibitor encoding p16 INK4a and p19 ARF, is a candidate for the … - Full text - MIT Libraries
S Zhang, ES Ramsay, BA Mock - Genetics, 1998 - dx.doi.org
... inhibitors mapped to a 6 cM interval of chromosome 4 between Ifna and Tal1. ... Sci Home
page J. Reichelt and TM Magin Hyperproliferation, induction of c-Myc and 14 ...
Cited by 31 - Web Search - pnas.org - pubmedcentral.nih.gov - adsabs.harvard.edu - all 7 versions »

[CITATION] Acute Lymphoblastic Leukemia
MG Alterations
Web Search

Circadian Transcription - Full text - MIT Libraries
E Munoz, M Brewer, R Baler - J. Biol. Chem, 2002 - jbc.org
... factors includes Myc (5), Arnt (16), Max (17), MyoD (18), Mad (19), upstream
stimulatory factor (USF) (20), Mxi1 (21), E47 (22), TFE3 (23), TAL1 (24), and the ...
Web Search - jbc.org

Inhibition of an erythroid differentiation switch by the helix-loop-helix protein Id 1. - Full text - MIT Libraries
J Lister, WC Forrester, MH Baron - J Biol Chem, 1995 - jbc.org
... receptor gene, or down-regulation of the endogenous Id1 or c-myc genes. ... helix (bHLH)
(Murre et al., 1989a) family of transcription factors, TAL1 (Visvader et al ...
Cited by 30 - Web Search - jbc.org - ncbi.nlm.nih.gov

chromosomal abnormalities - Full text - MIT Libraries
I SANCHEZ-GARCfA, TH RABBITTS - Biochemistry, 1994 - pnas.org
... tigated by using, respectively, TAL1 and FUS-CHOP pro- tein fragments as examples
from a leukemia and a sarcoma. ... TAL1 is a member of the bHLH family of ...
Web Search

Advances in the diagnosis of acute leukemia
C Hirsch-Ginsberg, YO Huh, J Kagan, JC Liang, SA … - Hematol Oncol Clin North Am, 1993 - ncbi.nlm.nih.gov
... ALL-1; AML1; H-RAS; HOX11; K-RAS; LCK; LYL1; MLL-1; MYC; N-RAS; RAS; RBTN1; SCL;
TAL-1; TAL1; TAL2; TAN; TCL-5; TCL3; TCRA; TCRB; TCRG; Tgt-1. Substances: Tumor ...
Cited by 7 - Web Search - Get it from MIT Libraries

Involvement of ABC7 in the biosynthesis of heme in erythroid cells: interaction of ABC7 with … - Full text - MIT Libraries
S Taketani, K Kakimoto, H Ueta, R Masaki, T … - Blood, 2003 - bloodjournal.org
... A specific band reacting with anti-c-Myc-tag in ABC7 cDNA-transfected cells ... be
controlled by GATA-1 and an erythroid-specific E-box-activating factor, Tal1. ...
Cited by 6 - Web Search - bloodjournal.org - bloodjournal.org - ncbi.nlm.nih.gov

I. Introduccion
KA Nacho-Vargas - medigraphic.com
... Estas traslocaciones yuxtaponen el gen MYC, que está localizado a nivel de 8q24 ...
7;9)(q34;q32) que originan la sobreexpresión de los oncogenes TAL1,HOX1,RHOM2 ...
Web Search - medigraphic.com

Interleukin-7 in T-cell acute lymphoblastic leukemia: An extrinsic factor supporting leukemogenesis?
J Barata, A Cardoso, V Boussiotis - Leukemia & Lymphoma, 2005 - dx.doi.org
... frequent in T-ALL [4], and lead to the abnormal activation of several transcription
factor genes, including members of the bHLH (MYC, TAL1, TAL2, LYL1, BHLHB1 ...
Web Search - taylorandfrancis.metapress.com

T-ALL: smoking guns and genes of interest - Full text - MIT Libraries
PD Aplan - Blood, 2004 - bloodjournal.org
... regions of antigen receptor genes (immunoglobulin or T-cell receptor genes) and
commonly involves transcription factors such as MYC, LMO2, or SCL (TAL1). ...
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