Cell fate decisions in early blood vessel formation
M Ema, J Rossant - Trends Cardiovasc Med, 2003 - ingentaconnect.com
... Cells that retain Flk1 activity have endothelial potential, cells that also activate
downstream transcription factors such as Tal1 and Runx1 gain primitive or ...
Cited by 4 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

FGFR1 and the Bloodline of the Vasculature - Full text - MIT Libraries
VWM van Hinsbergh, TJ Rabelink - Arteriosclerosis, Thrombosis, and Vascular Biology, 2005 - atvb.ahajournals.org
... including BMP-4 and VEGF, the growth factor receptors VEGFR-2 (Flk1, KDR) and FGFR1,
CD41, and transcription factors, such as SCL/Tal1 and Runx1 (required for ...
Web Search - atvbaha.org - atvb.ahajournals.org - ncbi.nlm.nih.gov

Mouse placenta is a major hematopoietic organ - Full text - MIT Libraries
M Alvarez-Silva, P Belo-Diabangouaya, J Salaun, F … - Development, 2003 - dev.biologists.org
... The appearance of placental progenitors and the first expression of the
transcription factors Scl/tal1 and Runx1 are simultaneous. ...
Cited by 8 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

RUNX1/AML1: a central player in hematopoiesis
T Okuda, M Nishimura, M Nakao, Y Fujita - Int J Hematol, 2001 - cardenjennings.metapress.com
... 2 groups: factors that regulate both primitive and definitive hematopoiesis,including
Tal1/SCL and LMO2/ rbtn2, and other factors, including RUNX1/AML1 (runt ...
Cited by 11 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype - Full text - MIT Libraries
JD Growney, H Shigematsu, Z Li, BH Lee, J … - Blood, 2005 - bloodjournal.org
... For example, Scl (Tal1) (the T-cell lymphocyte leukemia 1 gene) is essential for ...
46-48 To further characterize the role of Runx1 in adult hematopoiesis and in ...
Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov

A complex linkage in the developmental pathway of endothelial and hematopoietic cells
SI Nishikawa - Curr Opin Cell Biol, 2001 - cbi.pku.edu.cn
... The finding that tal1 (–/–) and lmo2 ... differentiation of definitive HPC and vascular
remodelling Runt related transcription factor 1 (Runx1), GATA-binding ...
Cited by 19 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, … - Full text - MIT Libraries
MA Hall, DJ Curtis, D Metcalf, AG Elefanty, K … - Blood, 2004 - dx.doi.org
... K. Akashi, IR Williams, NA Speck, and DG Gilliland Loss of Runx1 perturbs adult ... gene
ablation defines the stem-cell leukemia gene (SCL/tal1)-dependent window ...
Cited by 21 - Web Search - pnas.org - intl.pnas.org - pubmedcentral.nih.gov - all 7 versions »

Oligo GEArray® Human Hematopoietic Stem Cells and Hematopoiesis Microarray
S Conditions - search.cosmobio.co.jp
... IFI16, IL31RA, IRF4, IRF8, KLF6, LEF1, MAFB, MYC, NCOA6, NFYA, NOTCH1, NOTCH2, NOTCH4,
PAX5, RBPSUH, RHOH, RUNX1, SCAND1, STAT1, STAT3, STAT4, TAL1, VAV1, WWP1 ...
View as HTML - Web Search

The Gene SCL is Expressed during Early Hematopoiesis and Encodes a Differentiation-Related DNA- … - Full text - MIT Libraries
CG Begley, PD Aplan, SM Denning, BF Haynes, TA … - Blood, 2005 - pnas.org
... C. Hogan, L. Carlsson, N. Speck, J. Palis, and G. Keller Runx1 is essential ... Protein
Kinase Mediates the Hypoxia-induced Turnover of the TAL1/SCL Transcription ...
Cited by 116 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The bloody fate of endothelial stem cells - Full text - MIT Libraries
H Kubo, K Alitalo - Development, 2003 - dx.doi.org
... and the vascular defects associated with loss of Tal1 appear to be ... These authors
analyzed Runx1-deficient embryos, which lack definitive hematopoiesis and show ...
Cited by 10 - Web Search - genesdev.org - genesdev.org - ncbi.nlm.nih.gov - all 5 versions »

Leukaemia- a developmental perspective - Full text - MIT Libraries
S Izraeli - British Journal of Haematology, 2004 - blackwell-synergy.com
... development will be described through the examination of the developmental and the
leukaemogenic roles of three genes - RUNX1 (AML1), GATA1, and SCL (TAL1). ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Clonal variation of the immunogenotype in relapsedETV 6/RUNX 1-positive acute lymphoblastic leukemia …
M Peham, M Konrad, J Harbott, M Koenig, OA Haas, … - Genes Chromosomes and Cancer, 2004 - doi.wiley.com
... ETV6/RUNX1-positive pediatric leu- kemia: prognostic significance and therapeutic
approaches. ... and T cell receptor gene rearrange- ments and TAL1 deletions as ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

RBPj {kappa}-dependent Notch function regulates Gata2 and is essential for the formation of intra- … - Full text - MIT Libraries
A Robert-Moreno, L Espinosa, JL de la Pompa, A … - Development, 2005 - dx.doi.org
... the absence of hematopoietic progenitors, accompanied by the lack of expression
of the hematopoietic transcription factors Aml1/Runx1, Gata2 and Scl/Tal1. ...
Web Search - dev.biologists.org - dev.biologists.org - ncbi.nlm.nih.gov

Design principle of gene expression used by human stem cells: implication for pluripotency - Full text - MIT Libraries
S AIMS, P FINDINGS - The FASEB Journal, 2005 - fasebj.org
... the self-renewal and development of the particular tissue (eg, TP73L (p63), ITGB4,
and BNC for skin; and BMI1, CD34, TIE, KIT, TAL1 (SCL), and RUNX1 for blood ...
Cited by 2 - Web Search - dx.doi.org - arxiv.org - adsabs.harvard.edu - all 7 versions »

Absence of Yolk sac Hematopoiesis from Mice with a Targeted Disruption of the scl Gene - Full text - MIT Libraries
L Robb, I Lyons, R Li, L Hartley, F Kontgen, RP … - Proceedings of the National Academy of Sciences - pnas.org
... Orkin, K. Choi, and J. Rossant Combinatorial effects of Flk1 and Tal1 on vascular ...
C. Hogan, L. Carlsson, N. Speck, J. Palis, and G. Keller Runx1 is essential ...
Cited by 181 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - adsabs.harvard.edu

Expression of CD41 marks the initiation of definitive hematopoiesis in the mouse embryo - Full text - MIT Libraries
HK Mikkola, Y Fujiwara, TM Schlaeger, D Traver, SH … - Blood, 2003 - bloodjournal.org
... missing from runx1/AML1 / EBs that lack definitive hematopoiesis. These results
suggest that the expression of CD41, a candidate target gene of SCL/Tal1, and c ...
Cited by 29 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov

Mechanisms regulating the origins of the vertebrate vascular system - Full text - MIT Libraries
MS Saha, EA Cox, CW Sipe - Journal of Cellular Biochemistry, 2004 - doi.wiley.com
... show a substantial decrease in expression of flk1 and Scl-Tal1, which serve ... In terms
of cell intrinsic factors mediating the various signals, Runx1, Flt1, and ...
Web Search - ncbi.nlm.nih.gov

Endothelial progenitor cells: a source for therapeutic vasculogenesis - Full text - MIT Libraries
H Rumpold, D Wolf, R Koeck, E Gunsilius - J Cell Mol Med, 2004 - jcmm.ro
... development in the embryo • Markers and development of EC and HC • SCL/Tal •
Aml1/Runx1 ... EC and HC is that they share common markers like Scl1/Tal1,[8; 9 ...
Cited by 2 - View as HTML - Web Search - ncbi.nlm.nih.gov

SHORT REPORT Absence of SCL mutations in myeloid malignancies - Full text - MIT Libraries
E Delabesse, J Li, S Schnittger, W Hiddemann, AR … - British Journal of Haematology, 2003 - blackwell-synergy.com
... RUNX1 is essential for murine definitive haematopoiesis and mutations in its
DNA-binding (Runt ... The stem cell leukaemia (SCL) gene, also known as TAL1, encodes ...
Web Search - ncbi.nlm.nih.gov

Absence of SCL mutations in myeloid malignancies - Full text - MIT Libraries
G Munich - British Journal of Haematology, 2003 - ingentaconnect.com
... RUNX1 is essential for murine definitive haematopoiesis and mutations in its
DNA-binding (Runt ... The stem cell leukaemia (SCL) gene, also known as TAL1, encodes ...
Web Search

Design Principle of Gene Expression Used by Human Stem Cells; Implication for Pluripotency
R Title - arxiv.org
... development [eg TP73L (p63), ITGB4 and BNC for skin (27-29), and eg BMI1, CD34,
TIE, KIT, TAL1 (SCL), and RUNX1 for blood (30-32) – Table ...
View as HTML - Web Search - weizmann.ac.il - weizmann.ac.il

Transcription Factors: Normal and Malignant Development of Blood Cells
IJ Hematol - Int J Hematol, 2001 - cardenjennings.metapress.com
... friend of GATA (FOG), nuclear factor erythroid 2 (NF-E2), TAL1/SCL, erythroid ... which
focuses on myeloid differentiation,consists of the topics RUNX1(AML1)/CBFB ...
Web Search

Progress in Hematology
R Ono, T Nosaka, Y Hayashi - Int J Hematol, 2005 - cardenjennings.metapress.com
... 1,2]. The genes identified to date include Tal1/SCL and LMO2/rbtn2, which regulate
both primitive and definitive hematopoiesis, and AML1/RUNX1/CBF and CBF ...
Web Search

Scl is required for dorsal aorta as well as blood formation in zebrafish embryos - Full text - MIT Libraries
LJ Patterson, M Gering, R Patient - Blood, 2005 - bloodjournal.org
... One gene, expressed in hemangioblast populations, is scl/tal1, hereafter referred
to as ... erythroid, myeloid, and stem cell genes, gata1, pu.1, and runx1, may be ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

ANGIOGENESIS
H Identification - rndsystems.com
... SCL, also known as TAL1, is selectively expressed in cells of hematopoietic, vascular
and nerv- ous system origin 3,15 ... 6,16,17 Runx1, also known as CBFA2 and ...
View as HTML - Web Search - rndsystems.com - woongbee.com - rndsystems.com

The inv (16) encodes an acute myeloid leukemia 1 transcriptional corepressor - Full text - MIT Libraries
B Lutterbach, Y Hou, KL Durst, SW Hiebert - Blood, 2004 - dx.doi.org
... and Y. Ito Molecular basis for a dominant inactivation of RUNX1/AML1 by ... Murine
Erythroleukemia Cell Differentiation through Association with the TAL1 (or SCL ...
Cited by 33 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

SM Gribble AG Reid 2 AJ Bench 3 BJP Huntly 3
C Grace, AR Green, EP Nacheva - Leukemia, 2003 - nature.com
... interact with SCL/TAL1, 6 and the critical role of SCL in megakar- yopoiesis has ...
In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial ...
Web Search

The specification of early hematopoiesis in the mammal.
MH Baron, ST Fraser - Current Opinion in Hematology, 2005 - co-hematology.com
... Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development
in the ... GATA-2, GATA-3 and Runx1 were also detected in the vascular labyrinth. ...
Web Search - co-hematology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

State-of-the-Art Review
HKA MIKKOLA, SH ORKIN - JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH, 2002 - dx.doi.org
... SCL/Tal1 is a bHLH transcription factor originally identified through its ... Aml1/runx1
separates definitive hematopoiesis from embryonic erythropoiesis at the ...
Web Search - liebertonline.com - liebertonline.com

Translocation Breakpoints in Cancer
AM Oliveira, JA Fletcher - ehgonline.net
... encoding hematopoiesis- related transcription factors, including runt-related
transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) (RUNX1) and core ...
View as HTML - Web Search

Oncogenes et leucemies: historique et perspectives
S Gisselbrecht, BG Roussy - M e decine et Science, 2003 - erudit.org
... factor) qui comporte deux sous-unités CBFA2 (ou AML1, RUNX1) et CBFβ ... associées à
des complexes transcriptionnels comme les protéines LYL1, TAL1/SCL, LMO1 ...
Cited by 2 - Cached - Web Search

ETO, fusion partner in t (8; 21) acute myeloid leukemia, represses transcription by interaction with … - Full text - MIT Libraries
J Wang, T Hoshino, RL Redner, S Kajigaya, JM Liu - Mol. Endocrinol, 2005 - dx.doi.org
... JL Ford, J. Yu, B. Becknell, Y. Li, C. Liu, T. Vukosavljevic, SP Whitman, KS Chang,
JC Byrd, D. Perrotti, C. Plass, and G. Marcucci Interplay of RUNX1/MTG8 and ...
Cited by 307 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

acquises de la cellule souche hematopoietique ou d’un precurseur deja commis vers les lignees …
S YNTHESE - MEDECINE/SCIENCES, 2003 - ist.inserm.fr
... factor) qui comporte deux sous-unités CBFA2 (ou AML1, RUNX1) et CBFβ ... associées à
des complexes transcriptionnels comme les protéines LYL1, TAL1/SCL, LMO1 ...
View as HTML - Web Search - erudit.org

TEL deletion analysis supports a novel view of relapse in childhood acute lymphoblastic leukemia - Full text - MIT Libraries
J Zuna, AM Ford, M Peham, N Patel, V Saha, C … - Clin. Cancer Res, 2004 - clincancerres.aacrjournals.org
... using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions
as ... Clonal variation of the immunogenotype in relapsed ETV6/RUNX1-positive acute ...
Cited by 3 - Web Search - clincancerres.aacrjournals.org - ncbi.nlm.nih.gov

Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem … - Full text - MIT Libraries
S Gerecht-Nir, JE Dazard, M Golan-Mashiach, S … - Developmental Dynamics, 2005 - doi.wiley.com
... Hematopoietic/ECs 1 CD34 CD34 antigen 2 TAL1 T-cell acute lymphocytic leukemia 1 ...
6 GATA1 GATA binding protein 1 7 RUNX1 Runt-related transcription factor 1 ...
Cited by 2 - Web Search - weizmann.ac.il - weizmann.ac.il - ncbi.nlm.nih.gov

TRANSCRIPTION FACTORS
OFB CELLS - doi.wiley.com
... 4 Role of TAL1/SCL Transcription Factor in Normal and Leukemic Hematopoiesis 51 ... 85
6 RUNX1(AML1) and CBFB: Genes Required for the Development of All Definitive ...
Web Search

CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid … - Full text - MIT Libraries
GA Blobel, T Nakajima, R Eckner, M Montminy, SH … - Biochemistry, 1998 - dx.doi.org
... Home page, Blood Home page KE Elagib, FK Racke, M. Mogass, R. Khetawat, LL Delehanty,
and AN Goldfarb RUNX1 and GATA-1 coexpression and cooperation in ...
Cited by 136 - Web Search - pnas.org - pubmedcentral.nih.gov - surrey.ac.uk - all 7 versions »

Hematopoietic differentiation of human embryonic stem cells progresses through sequential … - Full text - MIT Libraries
ET Zambidis, B Peault, TS Park, F Bunz, CI Civin - Blood, 2005 - bloodjournal.org
... Gene expression analysis of differentiating hEBs revealed that initiation of
hematopoiesis correlated with increased levels of SCL/TAL1, GATA1, GATA2, CD34 ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Zebrafish as a model organism for blood diseases - Full text - MIT Libraries
J Berman, K Hsu, AT Look - British Journal of Haematology, 2003 - blackwell-synergy.com
... Thompson et al, 1998) and runxa (orthologue of mammalian runx1) (Burns et al ... mammalian
haematopoietic transcription factor genes, such as gata-2, tal1/scl and ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov

Clinical and biological importance of cytogenetic abnormalities in childhood and adult acute …
B Johansson, F Mertens, F Mitelman - Annals of Medicine, 2004 - dx.doi.org
Page 1. Clinical and biological importance of cytogenetic abnormalities
in childhood and adult acute lymphoblastic leukemia Bertil ...
Web Search - taylorandfrancis.metapress.com - ncbi.nlm.nih.gov - lu-research.lub.lu.se - Get it from MIT Libraries

Gene Expression Profiles of BRCA1-Linked, BRCA2-Linked, and Sporadic Ovarian Cancers - Full text - MIT Libraries
AA Jazaeri, CJ Yee, C Sotiriou, KR Brantley, J … - Journal of the National Cancer Institute, 2002 - jncicancerspectrum.oupjournals.org
... lignancies. BRCA1 tumors expressed higher levels of RUNX1/ AML1, whereas
BRCA2-associated samples preferentially expressed TAL1/SCL. Both ...
Cited by 44 - Web Search - math.wm.edu - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

ZEBRAFISH AS A MODEL ORGANISM FOR BLOOD DISEASES - Full text - MIT Libraries
OFV EMBRYOGENSIS - British Journal of Haematology, 2003 - ingentaconnect.com
... c- myb (Thompson et al, 1998) and runxa (orthologue of mammalian runx1) (Burns et ...
lian haematopoietic transcription factor genes, such as gata-2, tal1/scl and ...
Web Search

Tracking mesoderm induction and its specification to the hemangioblast during embryonic stem cell … - Full text - MIT Libraries
HJ Fehling, G Lacaud, A Kubo, M Kennedy, S … - Development, 2003 - dev.biologists.org
... sense) 5'GGT CTC GGG AAA GCA GTG GC3' (antisense); Runx1, 5'CCA ... The helix-loop-helix
transcription factor Scl (Tal1 – Mouse Genome Informatics) (Begley et al ...
Cited by 18 - Web Search - utsouthwestern.edu - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Hematopoietic Stem Cell Enrichment From the AGM Region of the Mouse Embryo
C Robin, E Dzierzak - Methods Mol Med, 2005 - biomed.humanapress.com
... CD34 + cells in the clusters express some transcriptional factors (SCL/Tal1, GATA2
and 3, c-myb; refs. ... AML-1 Acute myeloid leukaemia 1, Cbfa2, Runx1, PEBP2 ...
Web Search - journals.humanapress.com - neurosci.humanapress.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial … - Full text - MIT Libraries
A Kubo, V Chen, M Kennedy, E Zahradka, GQ Daley, G … - Blood, 2005 - bloodjournal.org
... Combinatorial effects of Flk1 and Tal1 on vascular and hematopoietic development ...
Runx1 is essential for hematopoietic commitment at the hemangioblast stage of ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

State-of-the-Art Review on Vascular Stem Cells and Angiogenesis
AJC BLOOR, J SANCHEZ, AR GREEN, B GOeTTGENS - JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH, 2002 - dx.doi.org
Page 1. JOURNAL OF HEMATOTHERAPY & STEM CELL RESEARCH 11:195–206 (2002) ©
Mary Ann Liebert, Inc. State-of-the-Art Review on Vascular ...
Web Search - liebertonline.com - liebertonline.com

Enforced Activation of STAT 5 A Facilitates the Generation of Embryonic Stem-Derived Hematopoietic … - Full text - MIT Libraries
JJ Schuringa, K Wu, G Morrone, MAS Moore - Stem Cells, 2004 - stemcells.alphamedpress.org
... genes were upregulated by STAT5A (1*6), as well as Runx1/AML1, vascular ... additionally
revealed a STAT5A(1*6)-induced upregulation of SCL/Tal1, Runx2, embryonic ...
Web Search - dx.doi.org - stemcells.alphamedpress.org - ncbi.nlm.nih.gov

Making waves in cancer research: new models in the zebrafish
S Berghmans, C Jette, D Langenau, K Hsu, R Stewart … - BioTechniques, 2005 - biotechniques.com
... The transient expression of the human RUNX1-CBF2T1, a fusion gene product of the
t(8;21) translocation in acute myeloid leukemia (AML) in embryos, resulted in ...
View as HTML - Web Search - biotechniques.com

Definitive hematopoietic stem cells first develop within the major arterial regions of the mouse … - Full text - MIT Libraries
M de Bruijn, NA Speck, MC Peeters, E Dzierzak - The EMBO Journal, 2000 - embojournal.npgjournals.com
... Tie-2 (Takakura et al., 1998) and Cbfa2 (known also as AML1 and Runx1) (North et
al ... Drake,CJ, Brandt,SJ, Trusk,TC and Little,CD (1997) TAL1/SCL is expressed in ...
Cited by 59 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 6 versions »

Unique gene expression signatures of independently-derived human embryonic stem cell lines - Full text - MIT Libraries
MJ Abeyta, AT Clark, RT Rodriguez, MS Bodnar, RA … - Human Molecular Genetics, 2004 - hmg.oupjournals.org
... CRIPTO), NODAL, EBAF (LEFTY), EPHA2, THY1, PROML1 (AC133), CXCR4 and TAL1 (SCL/TAL ...
Moreover, the genes GP130, STAT3, FOXD3, H19, FGF4, CD34, RUNX1, VEGFR2 (KDR ...
Cited by 15 - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »