Formation of in vivo Complexes Between the TAL1 and E2A Polypeptides of Leukemic T Cells - Full text - MIT Libraries
H Hsu, I Wadman, R Baer - Proceedings of the National Academy of Sciences - pnas.org
... Home page Z. Liu and ER Simpson Steroidogenic Factor 1 (SF-1) and SP1 Are Required
for ... Home page Y. Ono, N. Fukuhara, and O. Yoshie TAL1 and LIM-Only Proteins ...
Cited by 65 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction … - Full text - MIT Libraries
E Lecuyer, S Herblot, M Saint-Denis, R Martin, CG … - Blood, 2002 - dx.doi.org
... Stem cell leukemia (SCL, also known as TAL1 [T-cell acute lymphoblastic leukemia
1 ... factors, is tethered to DNA via a specificity protein 1 (Sp1) motif, through ...
Cited by 17 - Web Search - bloodjournal.org - bloodjournal.org - ncbi.nlm.nih.gov - all 7 versions »

TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell … - Full text - MIT Libraries
Y Ono, N Fukuhara, O Yoshie - Mol. Cell. Biol, 1998 - mcb.asm.org
... induction by TAL1 and LMO and that GATA3 acts in collaboration with TAL1 and LMO. ...
to DNA but still interacted with other transcription factors, such as SP1 (38 ...
Cited by 39 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 … - Full text - MIT Libraries
Z Xu, S Huang, LS Chang, AD Agulnick, SJ Brandt - Mol Cell Biol, 2003 - pubmedcentral.nih.gov
... of the ternary complex might be limiting for its assembly, Tal1 and Ldb1 ... 56), expression
of Ldb1, like that of the transcription factor Sp1, was maintained in ...
Cited by 9 - Web Search - dx.doi.org - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

ROLE OF THE TAL1/SCL TRANSCRIPTION FACTOR IN NORMAL AND LEUKEMIC HEMATOPOIESIS
SJ BRANDT - doi.wiley.com
... ETS- and Sp1/3-binding elements (Bockamp et al., 1998). The relatively low activity
of both of these promoters when stably introduced into TAL1- expressing ...
Web Search

Hemoglobins from bacteria to man: evolution of different patterns of gene expression - Full text - MIT Libraries
R Hardison - J. Exp. Biol, 1998 - jeb.biologists.org
... distal to the genes. Examples include a potential target for the hematopoietic
transcription factor TAL1. Key words: hemoglobin, evolution ...
Cited by 78 - Web Search - jeb.biologists.org - 163.238.8.180 - ncbi.nlm.nih.gov - all 5 versions »

The human beta-globin locus control region - Full text - MIT Libraries
PP Levings, J Bungert - Eur. J. Biochem, 2002 - content.febsjournal.org
... interactions known to occur among LCR-binding proteins involve those between the
GATA factors and between GATA factors and EKLF, LMO2/Tal1, and Sp1 [61-63]. ...
Cited by 24 - Cached - Web Search - ejbiochem.org - ingentaconnect.com - batzerlab.lsu.edu - all 8 versions »

Transcription factor Sp 3 is regulated by acetylation - Full text - MIT Libraries
H Braun, R Koop, A Ertmer, S Nacht, G Suske - Nucleic Acids Research, 2001 - nar.oupjournals.org
... Pascal,E. and Tjian,R. (1991) Different activation domains of Sp1 govern formation ...
the function of the basic helix–loop–helix transcription factor TAL1/SCL ...
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Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using … - Full text - MIT Libraries
AG Elefanty, CG Begley, D Metcalf, L Barnett, F … - Blood, 2004 - dx.doi.org
... and J. Rossant Combinatorial effects of Flk1 and Tal1 on vascular ... kit expression
in hematopoietic cells through functional interaction with Sp1 Blood, October 1 ...
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The GATA-E box-GATA motif in the EKLF promoter is required for in vivo expression - Full text - MIT Libraries
KP Anderson, SC Crable, JB Lingrel - Blood, 2000 - bloodjournal.org
... cells that apparently contacts the DNA through the GATA1 and Tal1 proteins. ... reveals
a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc ...
Cited by 8 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Multiple Proteins Binding to a GATA-E Box-GATA Motif Regulate the Erythroid Kruppel-like Factor(EKLF … - Full text - MIT Libraries
KP Anderson, SC Crable, JB Lingrel - J Biol Chem, 1998 - jbc.org
... the null mutations in each of these four genes, EKLF, GATA-1, Tal1, and Lmo2 ... been
shown to physically associate with both EKLF and the ubiquitous SP1 protein (18 ...
Cited by 21 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Transcriptional activity of TAL 1 in T cell acute lymphoblastic leukemia(T-ALL) requires RBTN 1 or-2 … - Full text - MIT Libraries
Y Ono, N Fukuhara, O Yoshie - J Biol Chem, 1997 - jbc.org
... TAL1 and RBTN may affect, somehow in a highly T cell-specific manner (see below),
the expression and/or activity of transcription factors such as Sp1 and CTF ...
Cited by 18 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

In Silico Identification of Regulatory Elements of GRIN 1 Genes
MK Mejia-Guerra, LR Lareo - Omics A Journal of Integrative Biology, 2005 - dx.doi.org
... 0 to 100 MZF-1 GAGA NF-Ins, Zn-15 NF-Ins, Zn-15 TGA1, TGA1, Sp1 Sp1 ... 0 to 100 Bsap
NF-Y NF-Y 100 to 200 Tal1 - Tal1 - Tal1 - 47S, 47S 47S, CFI-USP CFI-USP ...
Web Search - liebertonline.com - liebertonline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Transcriptional control of globin gene switching during vertebrate development
MH Baron - Biochim Biophys Acta, 1997 - immuneweb.xxmc.edu.cn
... family, which Ž . recognize CACCC motifs Table 1 and include the ubiquitous
proteins Sp1 and YY1, erythroid Ž . Kruppel-like factor ...
Cited by 22 - View as HTML - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Analysis of vertebrate SCL loci identifies conserved enhancers - Full text - MIT Libraries
B Gottgens, LM Barton, JG Gilbert, AJ Bench, MJ … - Nat. Biotechnol, 2000 - nature.com
... PubMed | ISI | ChemPort |; Drake, CJ, Brandt, SJ, Trusk, TC & Little, CD TAL1/SCL
is ... GATA- and SP1-binding sites are required for the full activity of the tissue ...
Cited by 85 - Web Search - welc.cam.ac.uk - gurdon.cam.ac.uk - ncbi.nlm.nih.gov - all 5 versions »

The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid … - Full text - MIT Libraries
JE Visvader, X Mao, Y Fujiwara, K Hahm, SH Orkin - Proc Natl Acad Sci USA, 1997 - dx.doi.org
... Chang, AD Agulnick, and SJ Brandt Identification of a TAL1 Target Gene ... expression
in hematopoietic cells through functional interaction with Sp1 Blood, October ...
Cited by 52 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Absence of Yolk sac Hematopoiesis from Mice with a Targeted Disruption of the scl Gene - Full text - MIT Libraries
L Robb, I Lyons, R Li, L Hartley, F Kontgen, RP … - Proceedings of the National Academy of Sciences - pnas.org
... and J. Rossant Combinatorial effects of Flk1 and Tal1 on vascular ... kit expression
in hematopoietic cells through functional interaction with Sp1 Blood, October 1 ...
Cited by 181 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - adsabs.harvard.edu

Promoter 1 of LMO2, a master gene for hematopoiesis, is regulated by the erythroid specific …
HH Anthropology, M Genetics, G Berlin - Gene Funct. Dis, 2000 - doi.wiley.com
... with a GATA1 cDNA expression plasmid (obtained by SH Orkin) and a SP1 cDNA expres ...
which is a binding site for a DNA binding complex including TAL1, E47, GATA1 ...
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Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function - Full text - MIT Libraries
SH Ou, LF Garcia-Martinez, EJ Paulssen, RB Gaynor - J. Virol, 1994 - pubmedcentral.nih.gov
... I, Baer R. Formation of in vivo complexes between the TAL1 and E2A ... R. Activation
of the AIDS retrovirus promoter by the cellular transcription factor, Sp1. ...
Cited by 25 - Web Search - jvi.asm.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Acetylation and modulation of erythroid Krueppel-like factor (EKLF) activity by interaction with … - Full text - MIT Libraries
W Zhang, JJ Bieker - Biochemistry, 1998 - dx.doi.org
... and RR Ratan Histone deacetylase inhibitors prevent oxidative neuronal death
independent of expanded polyglutamine repeats via an Sp1-dependent pathway PNAS ...
Cited by 353 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

Id4 is deregulated by at (6; 14)(p22; q32) chromosomal translocation in a B-cell lineage acute … - Full text - MIT Libraries
M Bellido, A Aventin, A Lasa, C Estivill, MJ … - Haematologica, 2003 - haematologica.org
... and ectopic expression of other bHLH proteins such as Lyl1 or Tal1 play a ... as a result
of the release of the normal inhibitory signals provided by Sp1 and Sp3 ...
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Identity of the beta-Globin Locus Control Region Binding Protein HS 2 NF 5 as the Mammalian Homolog … - Full text - MIT Libraries
LT Lam, EH Bresnick - J Biol Chem, 1998 - jbc.org
... E2 (26, 27), GATA-1 (28, 29), TAL-1 (30), USF (20, 31), SP1 (32), YY1 ... a conserved
region of HS2 containing an E box (34), which was a putative TAL1-binding site ...
Cited by 17 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Stem cell leukaemia gene and its role in normal and leukaemic haematopoiesis
CG Begley - haematologica.org
... The other, promoter 1b, is regulated by PU-1, SP1 and SP3 and is ... ization between
Lmo2 (Rbtn2) and Tal1 alters thy- mocyte development and potentiates T cell ...
View as HTML - Web Search - haematologica.it

Reconstitution of human beta-globin locus control region hypersensitive sites in the absence of … - Full text - MIT Libraries
KM Leach, K Nightingale, K Igarashi, PP Levings, … - Mol. Cell. Biol, 2001 - mcb.asm.org
... in vitro studies are observations that GATA factors are able to engage in a variety
of protein-protein interactions involving EKLF, Sp1, LMO2, and Tal1 (30, 42 ...
Cited by 15 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Intraembryonic Hematopoietic Cell Migration During Vertebrate Development - Full text - MIT Libraries
IIID HW, MW Kieran, FY Chan, LM Barone, K Yee, JA … - Proceedings of the National Academy of Sciences - pnas.org
... M. Gering, Y. Yamada, TH Rabbitts, and RK Patient Lmo2 and Scl/Tal1 convert non ... J.
Zhao, Y. Cao, C. Zhao, J. Postlethwait, and A. Meng An SP1-like transcription ...
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Tal 1/SCL Binding to Pericentromeric DNA Represses Transcription - Full text - MIT Libraries
J Wen, S Huang, SD Pack, X Yu, SJ Brandt, CT … - J Biol Chem, 2005 - jbc.org
... multiprotein complex with Ldb1 activates protein 4.2 through two E-box GATA elements
(20) and with Sp1 regulates glycophorin A (21). A Tal1-SCL multifactorial ...
Web Search - dx.doi.org - jbc.org - ncbi.nlm.nih.gov

Conserved E Boxes Function as Part of the Enhancer in Hypersensitive Site 2 of the beta-Globin Locus … - Full text - MIT Libraries
L Elnitski, W Miller, R Hardison - J. Biol. Chem, 2004 - jbc.org
... are placed adjacent to the bands lost upon treatment with antibody against TAL1. ...
globin gene expression in transgenic mice upon mutation of an Sp1-binding site ...
Cited by 33 - Web Search - jbc.org - ncbi.nlm.nih.gov

A novel DNA-binding protein, HS 2 NF 5, interacts with a functionally important sequence of the … - Full text - MIT Libraries
LT Lam, EH Bresnick - J Biol Chem, 1996 - jbc.org
... complexes, suggesting that TAL1 (SCL) is not present in the complexes (data not
shown). A 50-fold molar excess of a canonical Sp1 oligonucleotide completely ...
Cited by 26 - Web Search - jbc.org - ncbi.nlm.nih.gov

HbF reactivation in sibling BFU-E colonies: synergistic interaction of kit ligand with low-dose … - Full text - MIT Libraries
M Gabbianelli, U Testa, A Massa, O Morsilli, E … - Blood, 2003 - bloodjournal.org
... expression and developmental role of Id2 protein and TAL1/E2A heterodimer in ... c-kit
expression in hematopoietic cells through functional interaction with Sp1. ...
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Validating computer programs for functional genomics in gene regulatory regions
L Florea, M Li, C Riemer, B Giardine, W Miller, R … - Current Genomics, 2000 - ingentaconnect.com
... from the rest of the alignment (eg, APOA4, WT1, IRF1, OB, MHC2, IL2, TAL1, GMCSF);
ii ... 265 in both mouse and human and common binding sites for Sp1 near -240 and ...
Cited by 6 - Web Search

Combinatorial Complexity of 5' Alternative Acetylcholinesterase Transcripts and Protein Products - Full text - MIT Libraries
E Meshorer, D Toiber, D Zurel, I Sahly, A Dori, E … - Journal of Biological Chemistry - jbc.org
... zinc finger 1; RREB1, Ras-responsive element binding 1; SP1, specificity protein
1; ZBP, zinc finger binding protein; ZF5F, zinc finger protein 5; TAL1, T cell ...
Cited by 4 - Web Search - jbc.org - ncbi.nlm.nih.gov

Mechanisms regulating the origins of the vertebrate vascular system - Full text - MIT Libraries
MS Saha, EA Cox, CW Sipe - Journal of Cellular Biochemistry, 2004 - doi.wiley.com
... involved in vascular development, including VEGF, flk1, flt1, Scl- Tal1, and tie2 ...
and endoglin expression through physical interactions of Smad3/4, Sp1, and HIF ...
Web Search - ncbi.nlm.nih.gov

Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein - Full text - MIT Libraries
P Dhordain, O Albagli, RJ Lin, S Ansieau, S Quief, … - Proc. Natl. Acad. Sci. USA, 1997 - dx.doi.org
... the Zinc Finger and Interfering with DNA Binding Activity of Sp1 J. Biol. ... Murine
Erythroleukemia Cell Differentiation through Association with the TAL1 (or SCL ...
Cited by 143 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »

Phosphorylation of GATA-1 increases its DNA-binding affinity and is correlated with induction of …
CR Guidelines - nar.oupjournals.org
... 44,52) and heterotypic interactions, with transcription factors such as Sp1 and
EKLF (45 ... protein Ldb1/NL1, E2A, the basic helix-loop-helix protein TAL1/SCL and ...
Web Search

The LIM-only protein Lmo 2 is a bridging molecule assembling an erythroid, DNA-binding complex which … - Full text - MIT Libraries
IA Wadman, H Osada, GG Grutz, AD Agulnick, H … - The EMBO Journal, 1997 - embojournal.npgjournals.com
... The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding
complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. ...
Cited by 161 - Web Search - emboj.org - nature.com - ncbi.nlm.nih.gov - all 7 versions »

Members of the GATA family of transcription factors bind to the U3 region of Cas-Br-E and Graffi … - Full text - MIT Libraries
C Barat, E Rassart - J. Virol, 1998 - jvi.asm.org
... Products of the TAL1 oncogene: basic helix-loop-helix proteins phosphorylated at ...
interaction of GATA1 with erythroid Kruppel-like factor and Sp1 at defined ...
Cited by 8 - Web Search - pubmedcentral.nih.gov - jvi.asm.org - ncbi.nlm.nih.gov

ZFX transactivation of the HIV-1 LTR is cell specific and depends on core enhancer and TATA box … - Full text - MIT Libraries
C Gazin - Nucleic Acids Research, 1999 - nar.oupjournals.org
... 1 TATA box sequence is a key element of transactivation, while the Sp1 or NF ... line
was obtained from O. Bernard, characterised for the SIL-TAL1 rearrangements (15 ...
Cited by 3 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

E2A and HEB activate the pre-TCR alpha promoter during immature T cell development - Full text - MIT Libraries
A Takeuchi, S Yamasaki, K Takase, F Nakatsu, H … - J. Immunol, 2001 - jimmunol.org
... bHLH, basic helix-loop-helix; GFP, green fluorescent protein; Sp1, specificity protein
1 ... Helix-loop-helix (E2–5, HEB, TAL1 and Id1) protein interaction with ...
Cited by 12 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

SCL assembles a multifactorial complex that determines glycophorin A expression - Full text - MIT Libraries
R Lahlil, E Lecuyer, S Herblot, T Hoang - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... SCL/TAL1 is a hematopoietic-specific transcription factor of the basic helix-loop ...
multifactorial complex containing SCL as well as ubiquitous (E47, Sp1, and Ldb1 ...
Cited by 10 - Web Search - dx.doi.org - mcb.asm.org - ncbi.nlm.nih.gov

Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms - Full text - MIT Libraries
ME Massari, C Murre, R Articles - Mol. Cell. Biol, 2000 - dx.doi.org
... through ectopic expression of other bHLH proteins such as Lyl1 or Tal1, is an ...
translocate to the nucleus, where they activate, in concert with Sp1, low-density ...
Cited by 292 - Web Search - mcb.asm.org - www-biology.ucsd.edu - sig.biostr.washington.edu - all 9 versions »

Disruption of a novel regulatory element in the erythroid-specific promoter of the human PKLR gene … - Full text - MIT Libraries
R van Wijk, WW van Solinge, C Nerlov, E Beutler, T … - Blood, 2003 - bloodjournal.org
... transcription factor GATA-1 with the Kruppel family proteins Sp1 and EKLF. ... assembling
an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 ...
Cited by 10 - Web Search - bloodjournal.org - library.uu.nl - ncbi.nlm.nih.gov - all 5 versions »

E2A and HEB Activate the Pre-TCR Promoter During Immature T Cell Development
A Takeuchi, S Yamasaki, K Takase, F Nakatsu, H … - jimmunol.org
... E, E-box; S, Sp1; Y, YY1; I, Ikaros; G, GATA-1/2. 2159 ... 1998. Helix-loop-helix
(E2–5, HEB, TAL1 and Id1) protein interaction with the TCR enhancers. Int. ...
Web Search

Multiple negative elements contribute to repression of the HOX 11 proto-oncogene - Full text - MIT Libraries
RL Brake, UR Kees, PM Watt - Oncogene, 1998 - nature.com
... sequences were identi®ed for the transcription factors: AP-1, SP1, CREB, ATF,
ATF-3 ... Moreover, expression of the TAL1/SCL proto-oncogene is reported to be deregu ...
Cited by 8 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Molecular heterogeneity of regulatory elements of the mouse GATA-1 gene
A Ronchi, M Ciro, L Cairns, L Basilico, P Corbella … - Genes Funct, 1997 - ingentaconnect.com
... Factors involved are likely to be SP1 and/or BKLF, the unidentified Pal ... Interestingly,
it was recently shown that Lmo2 and Tal1, two factors crucial for the ...
Cited by 7 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Locus Control Regions: Description in the LCR-TRRDatabase
OA Podkolodnaya, VG Levitsky, NL Podkolodnyi - MOLECULAR BIOLOGY, 2001 - kluweronline.com
... 10 kb NF-E2 USF/TAL1 USF J-BP GATA-1 GATA-1 HS2NF CAC USF/TAL1 NF-E2 ... Sp1, EKLF
Enhancer regions Partial overcoming of the position effect ...
Cited by 1 - Web Search - springerlink.com - Get it from MIT Libraries

Molecular characterization of a new recombination of the SIL/TAL-1 locus in a child with T-cell … - Full text - MIT Libraries
E Carlotti, F Pettenella, R Amaru, S Slater, TA … - British Journal of Haematology, 2002 - blackwell-synergy.com
... of this deletion, the 5' non-coding portion of SIL is juxtaposed to first coding
exons of TAL-1 thus leading to an aberrant expression of TAL1 protein (Chen et ...
Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

The leukaemia-associated transcription factors EVI-1 and MDS 1/EVI 1 repress transcription and … - Full text - MIT Libraries
U Vinatzer, J Taplick, C Seiser, C Fonatsch, R … - British Journal of Haematology, 2001 - blackwell-synergy.com
... murine erythroleukemia cell differentiation through association with the Tal1 (or
Scl ... J., Rotheneder, H., Wintersberger, E. (1996) Interaction of Sp1 with the ...
Cited by 5 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Regulation of Cysteine-Rich Intestinal Protein, a Zinc Finger Protein, by Mediators of the Immune … - Full text - MIT Libraries
CG Regulation - The Journal of Infectious Diseases, 2000 - journals.uchicago.edu
... normal levels of other zinc finger proteins (eg, transcription factor Sp1). ... Protein
dimerization between LMO2 (Rbtn2) and Tal1 alters thymocyte development and ...
Cited by 9 - Web Search - ncbi.nlm.nih.gov

SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain … - Full text - MIT Libraries
S Herblot, AM Steff, P Hugo, PD Aplan, T Hoang - Nat Immunol, 2000 - nature.com
... controlled primarily by an upstream genomic region that contains three E boxes together
with a number of binding sites for other factors (YY1, ZBP-89, SP1) 30 ...
Cited by 51 - Web Search - nature.com - ncbi.nlm.nih.gov

BEGINNING AT THE BEDSIDE: A CASE OF T-CELL LEUKEMIA - Full text - MIT Libraries
VONT THEME, SCLDBYUD RESULTING, FAR ACTIVITY - Blood, 1999 - bloodjournal.org
... 58 , 136 , 137 , 139 Promoter 1b is regulated by PU-1, SP1, and SP3 ... T-cell leukemia:
Chromosome breakage 25 kilobase pairs downstream of the TAL1 proto oncogene ...
Web Search - bloodjournal.org