Quantitation of MYC gene expression in sporadic breast tumors with a real-time reverse transcription … - Full text - MIT Libraries
I Bieche, I Laurendeau, S Tozlu, M Olivi, D Vidaud … - Cancer Res, 1999 - cancerres.aacrjournals.org
... Primers and probes for the TBP and MYC genes were chosen with the assistance of
the computer programs Oligo 4.0 (National Biosciences, Plymouth, MN) and Primer ...
Cited by 96 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

… protein and the retinoblastoma gene product bind to overlapping epitopes on c-Myc and adenovirus E1 … - Full text - MIT Libraries
G Hateboer, H Timmers, A Rustgi, M Billaud, LJ van … - Proc Natl Acad Sci US A, 1993 - pubmedcentral.nih.gov
... A short peptide that spans the RB binding site of the E7 protein of human papilloma
virus type 16 interferes with the binding of c-Myc to TBP. ...
Cited by 41 - Web Search - ncbi.nlm.nih.gov

Direct role for Myc in transcription initiation mediated by interactions with TFII-I - Full text - MIT Libraries
AL Roy, C Carruthers, T Gutjahr, RG Roeder - Nature, 1993 - ncbi.nlm.nih.gov
... TFIID tau), TFII-I and the promoter. TBP probably interacts with Myc, but
only slowly. These observations indicate that Myc has the ...
Cited by 74 - Web Search

Stimulation of RNA polymerase II transcription initiation by recruitment of TBP in vivo - Full text - MIT Libraries
N Klages, M Strubin - Nature, 1995 - ncbi.nlm.nih.gov
... in yeast to show that a physical interaction with TBP is sufficient ... Humans; Protein
Binding; Proto-Oncogene Proteins c-myc/genetics; Proto-Oncogene Proteins c-myc ...
Cited by 99 - Web Search - ncbi.nlm.nih.gov

htert EXPRESSION CORRELATES WITH MYC OVER-EXPRESSION IN HUMAN PROSTATE CANCER
A Latil, D Vidaud, A Valeri, G Fournier, M Vidaud, … - Int. J. Cancer (Pred. Oncol.), 2000 - doi.wiley.com
... defining the levels of myc and htert expression relative to the tbp gene and the
calibrator, are given as follows: myc sample /tbp sample myc calibrator /tbp ...
Cited by 30 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

… MYC mutant alleles, their defective regulation by p107, and altered phosphorylation of the c-Myc … - Full text - MIT Libraries
AT Hoang, B Lutterbach, BC Lewis, T Yano, TY Chou, … - Mol. Cell. Biol, 1995 - mcb.asm.org
... (b) The diagram depicts the chimeric proteins GAL4-TBP and Myc TAD-VP16 interacting
to transactivate the reporter G5Inr- luciferase construct. ...
Cited by 55 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Functional interaction of the c-Myc transactivation domain with the TATA binding protein: evidence … - Full text - MIT Libraries
IJ McEwan, K Dahlman-Wright, J Ford, AP Wright - Biochemistry, 1996 - ncbi.nlm.nih.gov
... Taken together, these results identify TBP as an important target for the
c-myc transactivation domain, during transcriptional initiation. ...
Cited by 29 - Web Search - ncbi.nlm.nih.gov

… c-myc promoter binding protein (MBP-1) and TBP bind simultaneously in the minor groove of the c-myc … - Full text - MIT Libraries
D Chaudhary, DM Miller - Biochemistry, 1995 - ncbi.nlm.nih.gov
... MBP-1 binds to a sequence which overlaps the binding site for the general
transcription factor TBP, within the c-myc P2 promoter region. ...
Cited by 11 - Web Search - ncbi.nlm.nih.gov

Intracellular association of the protein product of the c-myc oncogene with the TATA-binding protein - Full text - MIT Libraries
S Maheswaran, H Lee, GE Sonenshein - Mol. Cell. Biol, 1994 - pubmedcentral.nih.gov
... These results indicate that intracellularly, c-Myc interacts with TBP, suggesting
a mechanism of interaction of this oncoprotein with the basal transcription ...
Cited by 45 - Web Search - mcb.asm.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Mechanism for the transcriptional repression by c-Myc on PDGF beta-receptor - Full text - MIT Libraries
H Izumi, C Molander, LZ Penn, A Ishisaki, K Kohno, … - J. Cell Sci, 2001 - jcs.biologists.org
... USA). For the expression of c-Myc, Max and TBP, the cDNAs were inserted in
a pcDNA3 vector (Invitrogen, Carlsbad, CA, USA). To obtain ...
Cited by 29 - Web Search - jcs.biologists.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The molecular role of Myc in growth and transformation: recent discoveries lead to new insights - Full text - MIT Libraries
LM Facchini, LZ Penn - FASEB J, 1998 - fasebj.org
... Myc binding to TBP through the Myc amino-terminal domain suggests that Myc may regulate
transcription through direct interaction with the basal transcription ...
Cited by 153 - Web Search - fasebj.org - ncbi.nlm.nih.gov

The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and … - Full text - MIT Libraries
HM Shen, N Michael, N Kim, U Storb - International Immunology, 2000 - intimm.oxfordjournals.org
... and IgM + IgD + B cells were isolated from human donors, and DNA prepared as described
(6). In the present study the analysis of the TBP, c-Myc and survivin ...
Cited by 14 - Web Search - intimm.oupjournals.org - ncbi.nlm.nih.gov

High Glucose Stimulates Early Response Gene c-Myc Expression in Rat Pancreatic beta Cells - Full text - MIT Libraries
JC Jonas, DR Laybutt, GM Steil, N Trivedi, JG … - J Biol Chem, 2001 - jbc.org
... Quintuplicate RT-PCR determination of the c-Myc/TBP ratio from the same RNA
preparation gave a within-assay coefficient of variation of 5.5%. ...
Cited by 24 - Web Search - jbc.org - ncbi.nlm.nih.gov

c-Myc target genes involved in cell growth, apoptosis, and metabolism - Full text - MIT Libraries
CV Dang - Mol. Cell. Biol, 1999 - mcb.asm.org
... is shown at the top tethered to the E box 5'-CACGTG-3'. c-Myc contacts TBP, although
the molecular mechanisms involved in c-Myc transactivation are not known. ...
Cited by 319 - Web Search - intl-mcb.asm.org - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

How Transcriptional Activators Bind Target Proteins - Full text - MIT Libraries
S Hermann, KD Berndt, AP Wright - J Biol Chem, 2001 - jbc.org
... The TBP + Myc C1 C2 mechanism (Equation 2) was modeled using the parameters obtained
above (dotted line). ... 4. Binding of TBP to c-Myc is entropy-driven. ...
Cited by 7 - Web Search - jbc.org - ncbi.nlm.nih.gov

An array of coactivators is required for optimal recruitment of TATA binding protein and RNA … - Full text - MIT Libraries
H Qiu, C Hu, S Yoon, K Natarajan, MJ Swanson, AG … - Mol. Cell. Biol, 2004 - pubmedcentral.nih.gov
... After inducing with SM for 2 h, cells were treated with formaldehyde and processed
for ChIP analysis to measure the binding of myc-TBP and myc-Rpb3p to the ...
Cited by 6 - Web Search - mcb.asm.org - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

p 73 Interacts with c-Myc to Regulate Y-box-binding Protein-1 Expression - Full text - MIT Libraries
H Uramoto, H Izumi, T Ise, M Tada, T Uchiumi, M … - J Biol Chem, 2002 - jbc.org
... 9A) but did not affect the association of TBP with c-Myc (Fig. ... B, the effect
of p73 on the interaction of GST-c-Myc with FLAG-TBP. ...
Cited by 14 - Web Search - jbc.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Specific local histone-DNA sequence contacts facilitate high-affinity, non-cooperative nucleosome … - Full text - MIT Libraries
J Gao, C Benyajati - Nucleic Acids Research, 1998 - nar.oupjournals.org
... Many transcription factors, such as glucocorticoid receptor (GR), GAL4, TFIIIA,
Sp1, NF-[kappa]B, TBP, Myc-Max and Max-Max dimers, and USF have been shown to ...
Cited by 5 - Web Search - nar.oxfordjournals.org - ingentaconnect.com - oup.co.uk - all 8 versions »

N and C-terminal sub-regions in the c-Myc transactivation region and their joint role in creating … - Full text - MIT Libraries
M Fladvad, K Zhou, A Moshref, S Pursglove, P … - J Mol Biol, 2005 - ncbi.nlm.nih.gov
... Myc1-167 is partly helical, binds both to the target proteins Myc modulator-1
(MM-1) and TATA box-binding protein (TBP), and displays the characteristics of a ...
Cited by 1 - Web Search

The Myc trilogy: lord of RNA polymerases - Full text - MIT Libraries
T Oskarsson, A Trumpp - Nature Cell Biology, 2005 - nature.com
... Grandori et al.show that c-Myc associates with TBP and TAF components of
the SL1 complex. In addition, they demonstrate that the ...
Cited by 1 - Web Search - nature.com - ncbi.nlm.nih.gov

… Myc negative autoregulation mechanism requires Myc-Max association and involves the c-myc P2 minimal … - Full text - MIT Libraries
LM Facchini, S Chen, WW Marhin, JN Lear, LZ Penn - Mol. Cell. Biol, 1997 - mcb.asm.org
... The Myc Negative Autoregulation Mechanism Requires Myc- Max Association and
Involves the c-myc P2 Minimal Promoter ... endogenous c-myc gene. ...
Cited by 42 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

… culture in low glucose induces apoptosis of rat pancreatic b-cells through induction of c-myc - Full text - MIT Libraries
M Van de Casteele, BA Kefas, Y Cai, H Heimberg, DK … - Biochemical and Biophysical Research Communications, 2003 - medschool.lsuhsc.edu
... The ratio “Myc/TBP” was then calculated for each sample. Insulin determinations. ...
1A). The c-myc/TBP mRNA ratio was low in freshly isolated islets. ...
Cited by 3 - View as HTML - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

TATA-Binding Protein Mutants That Are Lethal in the Absence of the Nhp6 High-Mobility-Group Protein - Full text - MIT Libraries
P Eriksson, D Biswas, Y Yu, JM Stewart, DJ … - Mol Cell Biol, 2004 - pubmedcentral.nih.gov
... previously (67, 68). The TBP-Myc-tagged allele (51) was provided by Rick Young
and crossed to generate the strains used here. Cells were ...
Cited by 1 - Web Search - dx.doi.org - mcb.asm.org - ncbi.nlm.nih.gov

Stimulation of Myc transactivation by the TATA binding protein in promoter-reporter assays - Full text - MIT Libraries
JF Barrett, LA Lee, CV Dang - BMC Biochemistry, 2005 - biomedcentral.com
... reporter assays and the TATA binding protein (TBP) has been reported to directly
bind Myc, we sought to determine the effect of TBP on Myc transactivation. ...
Cached - Web Search - dx.doi.org - pubmedcentral.nih.gov - citebase.eprints.org - all 7 versions »

Potential Role of the Early Response Gene c-myc in-Cell Adaptation to Changes in Glucose …
JC Jonas, R Laybutt, GM Steil, N Trivedi, GC Weir, … - diabetes.diabetesjournals.org
... As com- pared with freshly isolated islets from the same preparation, the ratio
of c-myc to TBP was increased approximately fivefold after overnight culture. ...
Web Search

… Protein and the Retinoblastoma Gene Product Bind to Overlapping Epitopes on c-Myc and Adenovirus E1 … - Full text - MIT Libraries
AL between c-Myc-mediated, T Repression, N … - Proceedings of the National Academy of Sciences - pnas.org
... A short peptide that spans the RB binding site of the E7 protein of human papilloma
virus type 16 interferes with the binding of c-Myc to TBP. ...
Web Search

BMC Biochemistry - Full text - MIT Libraries
JF Barrett, LA Lee, CV Dang - BMC Biochemistry, 2005 - biomedcentral.com
... reporter assays and the TATA binding protein (TBP) has been reported to directly
bind Myc, we sought to determine the effect of TBP on Myc transactivation. ...
View as HTML - Web Search

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I - Full text - MIT Libraries
C Grandori, N Gomez-Roman, ZA Felton-Edkins, C … - Nature Cell Biology, 2005 - nature.com
... 4) and c-Myc binding correlates with increased histone acetylation and recruit-
ment of TBP to the rDNA promoter (summarized in Fig. ...
Cited by 3 - Web Search - nature.com - ncbi.nlm.nih.gov

Interdependent Recruitment of SAGA and Srb Mediator by Transcriptional Activator Gcn4p - Full text - MIT Libraries
H Qiu, C Hu, F Zhang, GJ Hwang, MJ Swanson, C … - Mol Cell Biol, 2005 - mcb.asm.org
... 1 and 2. (Data for TBP-myc and RPB3-myc shown in the histogram were published
previously [53] and are provided here only for comparison.). ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast … - Full text - MIT Libraries
T Oda, K Kayukawa, H Hagiwara, HT Yudate, Y Masuho … - Mol. Cell. Biol, 2000 - mcb.asm.org
... blot). TBP and Myc-mABT1 in the whole cell lysate are shown in lane 3.
(C) Interaction of mABT1 with purified mTBP. Recombinant ...
Cited by 6 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Analyses of MYC, ERBB 2, and CCND 1 Genes in Benign and Malignant Thyroid Follicular Cell Tumors by …
I Bieche, B Franc, D Vidaud, M Vidaud, R Lidereau - Thyroid, 2001 - dx.doi.org
... MYC Upper primer 59-ACCACCAGCAGCGACTCTGA-39 117 Lower primer 59-TCCAGCAGAAGGTGATCCAGACT-
39 Probe 59-ACCTTTTGCCAGGAGCCTGCCTCT-39 TBP Upper primer 59 ...
Cited by 16 - Web Search - liebertonline.com - liebertonline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Who is MYC?
MYC Reconstructing, MYC Reconstructing, MYC … - dx.doi.org
... al. 1999 ; McMahon et al. 2000 ; Luscher 2001 ). MYC binds TBP along an
auxiliary pathway to control gene expression (Fig. 1). MAD ...
Cited by 28 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

… Regions of Estrogen Receptor alpha and beta Are Unstructured in Vitro and Show Different TBP … - Full text - MIT Libraries
A Warnmark, A Wikstrom, AP Wright, JA Gustafsson, … - Journal of Biological Chemistry - jbc.org
... Furthermore, evidence for a two-step binding model in which the unfolded activation
domain of c-Myc binds rapidly to TBP because of polar interactions and ...
Cited by 17 - Web Search - jbc.org - dx.doi.org - ncbi.nlm.nih.gov

Control of cell proliferation by Myc
C Bouchard, P Staller, M Eilers - trends in CELL BIOLOGY (Vol. 8), 1998 - biologie.uni-osnabrueck.de
... I, two proteins that activate transcription from initiator elements 25 ; binding
of Myc to YY-1 precludes * ** * * TAD NLS HLH LZ A B Bin1 p107 TBP α-tubulin ...
Cited by 97 - View as HTML - Web Search - imt.uni-marburg.de - ingentaconnect.com - all 6 versions »

SPN1, a Conserved Gene Identified by Suppression of a Postrecruitment-Defective Yeast TATA-Binding … - Full text - MIT Libraries
JA Fischbeck, SM Kraemer, LA Stargell - Genetics, 2002 - genetics.org
... Co-immunoprecipitation was performed on cell extracts from strains expressing
myc-TBP, myc-Spn1p, or untagged cells (non-myc). Immunoprecipitated ...
Cited by 2 - Web Search - lifesci.rutgers.edu - genetics.org - ncbi.nlm.nih.gov

THE MANY ROLES OF c-Myc IN APOPTOSIS - Full text - MIT Libraries
EB Thompson - Annual Review of Physiology, 1998 - phyto.annualreviews.org
... bind TBP of the basal TATA-box recognition group of proteins. As part of the
Myc/Max heterodimer, Myc also can associate with the transcription factor AP-2 and ...
Cited by 111 - Web Search - ncbi.nlm.nih.gov

AMY-1, a novel C-MYC binding protein that stimulates transcription activity of C-MYC - Full text - MIT Libraries
T Taira, J Maeda, T Onishi, H Kitaura, S Yoshida, … - Genes to Cells, 1998 - genestocellsonline.org
... Max and YY1 bind to the C- terminal region of C-MYC, while p107, Bin1
and TBP bind to the N-terminal region covering myc boxes. ...
Cited by 21 - Web Search - blackwell-synergy.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Expression of c-myc mRNA in Hepatocellular Carcinomas, Noncancerous Livers, and Normal Livers
M Ikeguchi, Y Hirooka, R Real-time, M Ikeguchi, F … - Pathobiology, 2004 - content.karger.com
... 10] . The ¢Ct value for c-myc in the PB samples was determined as follows:
¢Ct c-myc = TBP Ct value – c-myc Ct value. The mean ...
Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells - Full text - MIT Libraries
Z Li, S Van Calcar, C Qu, WK Cavenee, MQ Zhang, B … - Proceedings of the National Academy of Sciences, 2003 - pnas.org
... In particular, because c-Myc was shown to interact directly with TATA-box-binding
protein (TBP) (37, 38), the core component of the general transcription ...
Cited by 46 - Web Search - panomics.com - zlab.bu.edu - rulai.cshl.org - all 10 versions »

p73 independently of c-Myc represses transcription ofPDGF beta-receptor through interaction with NF- …
A Hackzell, H Uramoto, H Izumi, K Kohno, K Funa - jbc.org
... mechanism. p73 binds the C-terminal HAP domain of NF-YC, previously found
to be the interaction site with c-Myc and TBP. Since c ...
Web Search

The c-myc protein represses the lambda 5 and TdT initiators - Full text - MIT Libraries
S Mai, IL Martensson - Nucleic Acids Res, 1995 - pubmedcentral.nih.gov
... [PubMed] [Free Full Text]; Hernandez N. TBP, a universal ... Direct role for Myc in
transcription initiation mediated by interactions with TFII-I. Nature 1993 Sep 23 ...
Cited by 25 - Web Search - nar.oupjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

High glucose and hydrogen peroxide increase c-Myc and haeme-oxygenase 1 mRNA levels in rat … - Full text - MIT Libraries
HEAK Cardozo, DL Eizirik, JC Henquin, JC Jonas - Diabetologia, 2005 - springerlink.com
... The islet HO1 and c- Myc:TBP mRNA ratios were determined by simultaneous amplification
of c-Myc or HO1 plus TBP islet cDNAs using a validated radioactive hot ...
Web Search - ncbi.nlm.nih.gov

The ATM-related domain of TRRAP is required for histone acetyltransferase recruitment and Myc- … - Full text - MIT Libraries
J Park, S Kunjibettu, SB McMahon, MD Cole - Genes & Development, 2001 - genesdev.org
... The Spt components of SAGA facilitate TBP binding to a promoter at a post-activator ...
ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F ...
Cited by 32 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

Transcriptional suppression of HLA-B expression by c-Myc is mediated through the core promoter …
LTC Peltenburg, PI Schrier - Immunogenetics, 1994 - springerlink.com
... Springer-Verlag 1994 Lucy T. C. Peltenburg • Peter I. Schrier Transcriptional
suppression of HLA-B expression by c-Myc is mediated ... c-myc ex- pression. ...
Cited by 13 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal … - Full text - MIT Libraries
MW Frazier, X He, J Wang, Z Gu, JL Cleveland, GP … - Mol. Cell. Biol, 1998 - mcb.asm.org
... transrepress promoters lacking p53 binding sites (such as c-myc) in transient
transfection assays possibly by titrating TATA binding protein (TBP), TAFs, or CBP ...
Cited by 55 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 5 versions »

… Reptin regulate cell proliferation in early Xenopus embryos in collaboration with c-Myc and Miz-1. - Full text - MIT Libraries
C Etard, D Gradl, M Kunz, M Eilers, D Wedlich - Mech Dev, 2005 - ncbi.nlm.nih.gov
... They interact with many different proteins including TATA box binding protein (TBP),
beta-catenin and c-Myc and thus, potentially modulate different pathways. ...
Web Search

The TATA binding protein, c-Myc and survivin genes are not somatically hypermutated, while Ig and … - Full text - MIT Libraries
N Kim, HM Shen, N Michael, U Storb - International Immunology, 2000 - ingentaconnect.com
... is highly mutated. It was found that the TATA binding protein (TBP),
c-Myc and survivin genes are not hypermutated. This lack of ...
Web Search - ingentaconnect.com

Spt 3 and Mot 1 cooperate in nucleosome remodeling independently of TBP recruitment - Full text - MIT Libraries
I Topalidou, M Papamichos-Chronakis, G Thireos, D … - The EMBO Journal, 2004 - embojournal.npgjournals.com
... 1 (mot1-1) strains expressing the chimeric activator and the Myc-tagged Spt3 ... part,
either positively or negatively, in the mechanisms of TBP recruitment (Auble ...
Cited by 6 - Web Search - nature.com - imbb.forth.gr - pubmedcentral.nih.gov - all 9 versions »

Wild-type but not mutant p53 can repress transcription initiation in vitro by interfering with the …
N Ragimov, A Krauskopf, N Navot, V Rotter, M Oren, … - Oncogene, 1993 - ncbi.nlm.nih.gov
... TBP, wt but not mutant p53 specifically blocks the ability of TBP to engage ... Genes,
myc; Molecular Sequence Data; Mutation; Promoter Regions (Genetics); Protein p53 ...
Cited by 66 - Web Search - Get it from MIT Libraries

c-Myc/Max heterodimers bind cooperatively to the E-box sequences located in the first intron of the … - Full text - MIT Libraries
A Walhout, JM Gubbels, R Bernards, PC van der … - Nucleic Acids Research, 1997 - nar.oupjournals.org
... The N-terminal domain of c-Myc mediates activation of transcription possibly via ...
shown for the basal transcription factor, the TATA binding protein TBP (14 ,15 ...
Cited by 11 - Web Search - nar.oupjournals.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 6 versions »