Large family with maturity-onset diabetes of the young and a novel V121I mutation in HNF4A - Full text - MIT Libraries
CT Monney, V Kaltenrieder, P Cousin, C Bonny, DF … - Hum Mutat, 2002 - doi.wiley.com
... These genes play a crucial role in the glucose homeostasis as regulatory enzyme
(GCK) or transcription factors (TCF1, HNF4A, NEUROD1, IPF1, TCF2). ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Polymorphisms in the SLC2A2 (GLUT2) Gene Are Associated With the Conversion From Impaired Glucose … - Full text - MIT Libraries
O Laukkanen, J Lindstroem, J Eriksson, TT Valle, H … - Diabetes, 2005 - diabetes.diabetesjournals.org
... In this study, we investigated whether SNPs in the SLC2A2, GCK, TCF1, HNF4A, GIP,
and GLP-1 receptor (GLP-1R) genes predict the conversion from impaired ...
Web Search - diabetes.diabetesjournals.org

Half of Clinically Defined Maturity-Onset Diabetes of the Young Patients in Denmark Do Not Have … - Full text - MIT Libraries
A Johansen, J Ek, HB Mortensen, O Pedersen, T … - The Journal of Clinical Endocrinology & Metabolism - jcem.endojournals.org
... criteria. This means that in more than half of the Danish Caucasian MODY families
we found no mutations in TCF1, GCK, or HNF4A. Fifteen ...
Web Search - jcem.endojournals.org - ncbi.nlm.nih.gov

Identification of novel GCK and HNF 1 A/TCF 1 mutations and polymorphisms in German families with … - Full text - MIT Libraries
D Toaima, A Naeke, J Wendenburg, K Praedicow, J … - Human Mutation, 2005 - doi.wiley.com
... hepatocyte nuclear factor 4-alpha (HNF4A; MODY1; MIM# 125850); glucokinase (GCK,
MODY2; MIM# 125851), hepatocyte nuclear factor 1-alpha (HNF1A/TCF1; MODY3; MIM ...
Web Search - ncbi.nlm.nih.gov

Transcription factors in liver development, differentiation, and regeneration - Full text - MIT Libraries
RH Costa, VV Kalinichenko, AXL Holterman, X Wang - Hepatology, 2003 - ncbi.nlm.nih.gov
... Trans-Activators; Transcription Factors; hepatocyte nuclear factor 6; TCF1 protein,
human; HNF4A protein, human; hepatocyte nuclear factor 1-beta; DNA. Grant Support ...
Cited by 22 - Web Search - ncbi.nlm.nih.gov

Rapid modulation of liver-specific transcription factors after injury
PA Burke, M Drotar, M Luo, M Yaffe, RA Forse - Surgery, 1994 - ncbi.nlm.nih.gov
... RNA, Messenger; Transcription Factors; transcription factor C-EPB; TCF1 protein,
human; HNF4A protein, human; hepatocyte nuclear factor 1-beta; Fibrinogen. PMID ...
Cited by 17 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and …
RS Herbst, U Nielsch, F Sladek, E Lai, LE Babiss, … - New Biol, 1991 - ncbi.nlm.nih.gov
... Transcription Factors; hepatocyte nuclear factor 3alpha; TCF1 protein, human; HNF4A
protein, human; hepatocyte nuclear factor 3gamma; hepatocyte ...
Cited by 13 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Variation in NCB5OR - Full text - MIT Libraries
G Andersen, L Wegner, CS Rose, J Xie, H Zhu, K … - Diabetes, 2004 - diabetes.diabetesjournals.org
... OHAs (61%). The patients were excluded for mutations known to be present
in the MODY genes TCF1, HNF4A, and GCK. In these probands ...
Web Search - diabetes.diabetesjournals.org - ncbi.nlm.nih.gov

Combinatorial crosstalk of transacting factors binding to the L-type pyruvate kinase promoter …
N Puzenat, S Vaulont, A Kahn, M Raymondjean - Biochem Biophys Res Commun, 1992 - ncbi.nlm.nih.gov
... Phosphoproteins; Plasmids; Transcription Factors; TCF1 protein, human; HNF4A
protein, human; hepatocyte nuclear factor 1-beta; Pyruvate ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

The orphan nuclear receptor HNF4alpha determines PXR-and CAR-mediated xenobiotic induction of CYP3A4 - Full text - MIT Libraries
RG Tirona, W Lee, BF Leake, LB Lan, CB Cline, V … - Nat Med, 2003 - nature.com
... 4α (HNF4α; HNF4A) increased basal and PXR-mediated reporter activities with the
CYP3A4 promoter. Hepatocyte nuclear factor-1α (HNF1α; TCF1) and liver ...
Cited by 55 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Expression of HNFs and C/EBP alpha is correlated with immunocytochemical differentiation of cell … - Full text - MIT Libraries
T Ishiyama, J Kano, Y Minami, T Iijima, Y … - Cancer Sci, 2003 - ncbi.nlm.nih.gov
... RNA, Neoplasm; Transcription Factors; TCF1 protein, human; HNF4A protein,
human; hepatocyte nuclear factor 3beta; hepatocyte nuclear ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Maturity-onset diabetes of the young (MODY): the history of its dismemberment
P Froguel - Ann Endocrinol (Paris), 2003 - ncbi.nlm.nih.gov
... Factors/genetics. Substances: Phosphoproteins; Transcription Factors; TCF1 protein,
human; HNF4A protein, human; hepatocyte nuclear factor 1-beta; Glucokinase. ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Early-onset diabetes in the Mexican population: prevalence, genetic and metabolic features - Full text - MIT Libraries
T Factors - Rev Invest Clin, 2003 - ncbi.nlm.nih.gov
... Substances: Phosphoproteins; Transcription Factors; TCF1 protein, human; HNF4A protein,
human; hepatocyte nuclear factor 1-beta. PMID: 14515676 [PubMed - indexed ...
Web Search - ncbi.nlm.nih.gov

Postnatal changes in gene expression of retinal dehydrogenase and retinoid receptors in liver of …
Y Ogura, K Suruga, H Mochizuki, T Yamamoto, S … - Life Sci, 2004 - ncbi.nlm.nih.gov
... Retinoic Acid; Transcription Factors; TCF1 protein, human; HNF4A protein,
human; hepatocyte nuclear factor 1-beta; Tretinoin; Aldehyde ...
Web Search - Get it from MIT Libraries

A common regulatory locus affects both HNF4/HNF1alpha pathway activation and sensitivity to LPS- …
GA Bulla, E Givens, S Brown, B Oladiran, D Kraus - ncbi.nlm.nih.gov
... Substances: Lipopolysaccharides; Phosphoproteins; Transcription Factors; TCF1 protein,
human; HNF4A protein, human; hepatocyte nuclear factor 1-beta. Grant Support ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Genetic epidemiology of diabetes - Full text - MIT Libraries
MA Permutt, J Wasson, N Cox - J. Clin. Invest, 2005 - jci.org
... and hepatocyte nuclear factors 4 and 1 (HNF4A and TCF1) as genes in which a single
mutation could lead to the complex metabolic phenotype of diabetes (see ref. ...
Cited by 1 - Web Search - pubmedcentral.nih.gov - jci.org - ncbi.nlm.nih.gov

Identification of a locus for maturity-onset diabetes of the young on chromosome 8p23 - Full text - MIT Libraries
SH Kim, X Ma, S Weremowicz, T Ercolino, C Powers, … - Diabetes, 2004 - diabetes.diabetesjournals.org
... The first MODY gene to be recognized was glucokinase (GCK) (2,3), followed by
hepatocyte nuclear factors HNF-1 (TCF1) and HNF-4 (HNF4A) (4,5). GCK is the ...
Cited by 4 - Web Search - intl-diabetes.diabetesjournals.org - ncbi.nlm.nih.gov - joplink.net - all 5 versions »

The genetics of diabetes: a progress report
AL Gloyn - Practical Diabetes International, 2001 - doi.wiley.com
... encoding an important b-cell enzyme, glucokinase and, four genes encoding transcription
factors, hepatocyte nuclear factors HNF 1a (TCF1), 4a (HNF4a) and 1b ...
Web Search - doi.wiley.com

Growing Evidence for Diabetes Susceptibility Genes from Genome Scan Data - Full text - MIT Libraries
MI McCarthy - Current Science, 2003 - current-reports.com
... having selected this chromosome for attention on the basis of either the FUSION
results or the localization of the MODY susceptibility gene HNF4A to chromosome ...
Cited by 19 - Web Search - current-reports.com - biomedcentral.com - ncbi.nlm.nih.gov

Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell …
V Corrections, R Synopsis, RR Articles, XML … - dx.doi.org
... HNF4A (the MODY1 gene) encodes an orphan hormone nuclear receptor that, together
with TCF1 (LocusLink ID 6927), encoding HNF1α, TCF2 (LocusLink ID 6928 ...
Web Search - biology.plosjournals.org

Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell …
XML Download, R Synopsis, RR Articles, R Articles, … - dx.doi.org
... HNF4A (the MODY1 gene) encodes an orphan hormone nuclear receptor that, together
with TCF1 (LocusLink ID 6927), encoding HNF1α, TCF2 (LocusLink ID 6928 ...
Web Search - biology.plosjournals.org - plbi.allenpress.com

The role of transcription factors in maturity-onset diabetes of the young - Full text - MIT Libraries
SM Mitchell, TM Frayling - Mol. Genet. Metab, 2002 - ncbi.nlm.nih.gov
... Five of the six MODY genes, TCF1 (encoding HNF-1alpha), TCF2 (encoding HNF-1beta)
HNF4A, insulin promoter factor (IPF)1, and NEUROD1, are transcription factors ...
Cited by 5 - Web Search

Hyperinsulinism-Induced Hypoglycaemia: Towards an Understanding of the Molecular Mechanisms of …
KE Cosgrove, RM Shepherd, A Natarajan, KJ Lindley, … - content.karger.com
... dysfunction phosphate dehydrogenase-2 T2DM Diabetes 125850 HNF4 HNF4A 20q12–q13.
1 Regulator of HNF1 expression T2DM Diabetes 601407 HNF1 TCF1 12q24.2 ...
Web Search - content.karger.com

The Inherited Basis OF Diabetes Mellitus: - Full text - MIT Libraries
C Traits - Annu. Rev. Genomics Hum. Genet, 2003 - psych.umn.edu
... to MODY 1 or MODY 2, and led them to mutations in the TCF1 gene encoding ... MODY 1 is
caused by mutations in the HNF4A gene, which encodes HNF-4α, a nuclear ...
View as HTML - Web Search - fluid.annualreviews.org

Public health impact of genetic tests at the end of the 20th century
M Gwinn, IM Lubin, W Burke, MJ Khoury - %5Cwww.cdc.gov
... Diabetes mellitus, MODY types 5, 4, 3, 2, 1 TCF2 (HNF1 beta), IPF1, TCF1
(HNF1A), GCK, HNF4A AL 1 million people in US diagnosed ...
View as HTML - Web Search - %5Cwww.cdc.gov - cdc.gov - cdc.gov

Genetic epidemiology of type 1 diabetes - Full text - MIT Libraries
JN Hirschhorn - Pediatric Diabetes, 2003 - ingentaconnect.com
... HNF4A (hepatocyte nuclear factor 4a) MODY (MODY1) 125850 (126) GCK (glucokinase)
MODY (MODY2) 125851 (127) TCF1 (HNF1A, hepatocyte nuclear factor 1a) ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Control of Pancreas and Liver Gene Expression by HNF Transcription Factors - Full text - MIT Libraries
DT Odom, N Zizlsperger, DB Gordon, GW Bell, NJ … - Science, 2004 - sciencemag.org
... For clarity, some gene promoters have been designated by the names of their protein
products (eg, HNF1 for TCF1, SHP for NR0B2, HNF4 7 for HNF4A P2, and HNF1ß ...
Cited by 86 - Web Search - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

The IHPK 1 gene is disrupted at the 3 p 21. 31 breakpoint of t (3; 9) in a family with type 2 … - Full text - MIT Libraries
J Kamimura, K Wakui, H Kadowaki, Y Watanabe, K … - Journal of Human Genetics, 2004 - springerlink.com
... 2000), TCF1 at 12q24.2 (Triggs- Raine et al. 2002), SLC2A4 at 17p13 (Kusari et al.
1991), TCF2 at 17qcen–q21.3 (Furuta et al. 2002), or HNF4A at 20q12–q13 ...
Web Search - ncbi.nlm.nih.gov

Nonsense and Missense Mutations in the Human Hepatocyte Nuclear Factor-1ss Gene (TCF2) and Their … - Full text - MIT Libraries
H Furuta, M Furuta, T Sanke, K Ekawa, T Hanabusa, … - The Journal of Clinical Endocrinology & Metabolism - intl-jcem.endojournals.org
... MUTATIONS IN THE genes encoding the ß-cell transcription factors, hepatocyte nuclear
factor (HNF)-1 (TCF1), -1ß (TCF2), and -4 (HNF4A), insulin promoter ...
Cited by 9 - Web Search - dx.doi.org - jcem.endojournals.org - ncbi.nlm.nih.gov - all 5 versions »

The genetics of type 2 diabetes
CM Lindgren, JN Hirschhorn - Endocrinologist, 2001 - theendocrinologist.org
... by mutations in the hepatocyte nuclear factor 4α gene, (HNF-4α or HNF4A; MIM*600281 ...
MIM #125851 [33,34]), whereas mutations in the HNF-1α (TCF1, MIM*142410 ...
Cited by 9 - Web Search - theendocrinologist.org

Large-scale investigation of genomic markers for severe periodontitis - Full text - MIT Libraries
A Suzuki, G Ji, Y Numabe, K Ishii, M Muramatsu, K … - Odontology, 2004 - springerlink.com
... ABP1 1 CD81 3 HFE 3 ACACB 2 CHGB 1 HGF 3 ACADL 1 CHI3L1 1 HNF4A 2 ACE 5 CST 1 HSPG2
1 ... NOTCH4 2 PRODH 1 TBXAS1 4 NOX1 1 PRSS11 9 TCF1 2 NOX3 6 PSMB9 1 CTF2 3 ...
Web Search - ncbi.nlm.nih.gov

Application of pooled genotyping to scan candidate regions for association with HDL cholesterol …
DA Hinds, AB Seymour, LK Durham, P Banerjee, DG … - Hum. Genomics, 2004 - ingentaconnect.com
... CEL CLN2 CRP CTSC EPHB6 ESR2 ESRRB FPR1 G6PC GHSR GJA4 GLRA1 GPRC5B HAT HDL-CBP
HNF4A KCNJ9 LIPE LIPG LOC51275 MBTPS1 ... SPTLC1 SPTLC2 SSTR1 TCF1 TRHR TSHR UPS3 ...
Cited by 7 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Progress in defining the molecular basis of type 2 diabetes mellitus through susceptibility-gene … - Full text - MIT Libraries
MI McCarthy - Human Molecular Genetics, 2004 - hmg.oupjournals.org
... Mutations in one of these transcription factors—HNF1A (TCF1)—accounts for around
two ... convincing associations with variants adjacent to the HNF4A P2 promoter ...
Cited by 6 - Web Search - hmg.oupjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte … - Full text - MIT Libraries
NL Lazarevich, OA Cheremnova, EV Varga, DA … - Hepatology, 2004 - doi.wiley.com
... or reduced in fgHCCs. These included Hnf4 (both 1 and 7 iso- forms), Hnf1
(Tcf1) and –1 (Tcf2), Foxa3, Hnf6 (One- cut1), C/ebpa ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Contribution of Mendelian disorders to common chronic disease: Opportunities for recognition, … - Full text - MIT Libraries
MT Scheuner, PW Yoon, MJ Khoury - American Journal of Medical Genetics, 2004 - doi.wiley.com
Page 1. American Journal of Medical Genetics Part C (Semin. Med. Genet.)
125C:50–65 (2004) ARTICLE Contribution of Mendelian Disorders ...
Cited by 2 - Web Search - cdc.gov - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Transcriptional networks controlling pancreatic development and beta cell function - Full text - MIT Libraries
JM Servitja, J Ferrer - Diabetologia, 2004 - springerlink.com
Page 1. Abstract Transcription factors provide the genetic instructions that drive
pancreatic development and enable mature beta cells to function properly. ...
Cited by 7 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Retinoids: pleiotropic agents of therapy for vascular diseases
JW Streb, JM Miano - Curr Drug Targets Cardiovasc Haematol Disord, 2003 - ingentaconnect.com
... HNF4A Hepatocyte nuclear factor 4-a GAGTCAAGGGTCA D -418/-399 ... TCF1 Transcription
Factor 1, hepatic; LF-B1, hepatic nuclear factor (HNF1), albumin proximal ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Original Research Report
ESC Differentiation - dx.doi.org
... GA17; GAD1; GAD2; GATA6; GCK; HCA66; HES5; HLXB9; HNF3B; HNF4A; HNF4G; HRY ... PAX4;
PMSCL1; POU3F4; PPY; PTF1A; PTMAP7; REG1A; SDCCAG8; SLC2A2; SST; TCF1; TCF2 ...
Web Search - liebertonline.com - liebertonline.com

Candidate Gene Association Study in Type 2 Diabetes Indicates a Role for Genes Involved in β-Cell … - Full text - MIT Libraries
S Material, I Barroso, J Luan, R Middelberg, N … - PLoS Biol, 2003 - pubmedcentral.nih.gov
... HNF4A (the MODY1 gene) encodes an orphan hormone nuclear receptor that, together
with TCF1 (LocusLink ID 6927), encoding HNF1α, TCF2 (LocusLink ID 6928 ...
Web Search

Stanford Genome Technology Center
MIM Gene, D Reference - transgenomic.co.kr
Page 1. List of human genes screened entirely or partly by DHPLC (as of
December 15, 2003) Page 1 of 70 Stanford Genome Technology ...
Web Search - insertion.stanford.edu - transgenomic.co.kr - transgenomic.com.cn

Hunting for a hypoglycemia gene: Severe neonatal hypoglycemia in a consanguineous family - Full text - MIT Libraries
A Molven, U Rishaug, GE Matre, PR Njoelstad, O … - American Journal of Medical Genetics, 2002 - doi.wiley.com
... TCF1 12q24.2 Hepatocyte nuclear factor 1a Homeodomain TF D12S79, D12S321, D12S366,
UC ... HNF4A 20q12-q13.1 Hepatocyte nuclear factor 4a Nuclear hormone receptor TF ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

The human obesity gene map: the 2000 update - Full text - MIT Libraries
L Perusse, YC Chagnon, SJ Weisnagel, T Rankinen, E … - Obes Res, 2001 - obesityresearch.org
Page 1. Review The Human Obesity Gene Map: The 2000 Update Louis Pérusse,*
Yvon C. Chagnon,* S. John Weisnagel,* Tuomo Rankinen,† Eric ...
Cited by 51 - Web Search - obesityresearch.org - obesityresearch.org - ncbi.nlm.nih.gov - all 5 versions »