TP53 mutations are frequent in malignant NF1 tumors
E Legius, H Dierick, R Wu, BK Hall, P Marynen, JJ … - Genes Chromosomes Cancer, 1994 - ncbi.nlm.nih.gov
TP53 mutations are frequent in malignant NF1 tumors. Legius E, Dierick H,
Wu R, Hall BK, Marynen P, Cassiman JJ, Glover TW. Center ...
Cited by 36 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Rb and TP53 pathway alterations in sporadic and NF1-related malignant peripheral nerve sheath tumors - Full text - MIT Libraries
S Birindelli, F Perrone, M Oggionni, C Lavarino, B … - Lab Invest, 2001 - nature.com
Nature.com
Cited by 17 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Apparent preferential loss of heterozygosity atTSC 2 overTSC 1 chromosomal region in tuberous …
C Carbonara, L Longa, E Grosso, G Mazzucco, C … - Genes Chromosomes and Cancer, 1996 - ncbi.nlm.nih.gov
... lesions, we have tested for loss of heterozygosity the two TSC loci (TSC1 and TSC2)
and seven tumor suppressor gene-containing regions (TP53, NF1, NF2, BRCA1 ...
Cited by 51 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Alterations at chromosome 17 loci in peripheral nerve sheath tumors
RA Lothe, A Slettan, G Saeter, A Brogger, AL … - J Neuropathol Exp Neurol, 1995 - ncbi.nlm.nih.gov
... during development of MPNST in patients with NF1. In contrast to other reports,
we did not find evidence for a homozygous mutated condition of the TP53 gene in ...
Cited by 30 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Genetic aberrations in the development and subsequent progression of myelodysplastic syndrome
S Misawa, S Horiike, H Kaneko, K Kashima - Leukemia, 1997 - ncbi.nlm.nih.gov
... We performed longitudinal analyses of chromosomes and studied the configuration
of NRAS, TP53, NF1, and cFMS genes in 70 patients with myelodysplastic syndrome ...
Cited by 8 - Web Search - Get it from MIT Libraries

Genetic alterations in a malignant schwannoma from a patient with neurofibromatosis (NF1)
RA Lothe, G Saeter, HE Danielsen, AE Stenwig, B … - Pathol Res Pract, 1993 - ncbi.nlm.nih.gov
... gene may function as a tumour suppressor gene, and that, either by effect of dose
reduction or complete inactivation, both the NF1 gene and the TP53 gene may ...
Cited by 16 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Molecular and cytogenetic analysis of tumors in von Recklinghausen neurofibromatosis
TW Glover, CK Stein, E Legius, LB Andersen, A … - Genes Chromosomes Cancer, 1991 - ncbi.nlm.nih.gov
... EVI2B; HRAS; NF1; TP53. Substances: DNA, Neoplasm; Genetic Markers. Grant Support:
NS23427/NS/NINDS. PMID: 1906341 [PubMed - indexed for MEDLINE]
Cited by 45 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Kinetic profiles by topographic compartments in muscle-invasive transitional cell carcinomas of the …
A Blanes, J Rubio, A Martinez, HJ Wolfe, SJ Diaz- … - Am J Clin Pathol, 2002 - ncbi.nlm.nih.gov
Kinetic profiles by topographic compartments in muscle-invasive transitional
cell carcinomas of the bladder: role of TP53 and NF1 genes. ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Identification of two distinct deletion targets at 11 q 23 in cutaneous malignant melanoma - Full text - MIT Libraries
RA Herbst, R Gutzmer, F Matiaske, S Mommert, U … - International Journal of Cancer, 1999 - doi.wiley.com
... In malignant melanoma, the 2 known tumor suppressors, TP53 and NF1, as well as other
chromosomal regions, including 1p, 6q, 9p, 10q, 11p and 16q, have been ...
Cited by 22 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Biallelic inactivation of TP 53 rarely contributes to the development of malignant peripheral nerve …
RA Lothe, B Smith‐Soerensen, M Hektoen, AE … - Genes Chromosomes and Cancer, 2001 - doi.wiley.com
... From these animal models, one may speculate on a synergistic effect of TP53
and NF1 mutations in malignant transformation in humans. ...
Cited by 9 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Loss of NF1 alleles distinguish sporadic from NF1-associated pilocytic astrocytomas
L Kluwe, C Hagel, M Tatagiba, S Thomas, D Stavrou, … - J Neuropathol Exp Neurol, 2001 - jneuropath.com
... markers, we examined losses of NF1 alleles on the long arm of chromosome 17 in 12
NF1-associated and 25 sporadic pilocytic astrocytomas. The TP53 gene region ...
Cited by 21 - Web Search - neur.allenpress.com - apt.allenpress.com - ncbi.nlm.nih.gov - all 7 versions » - Get it from MIT Libraries

Increased expression of the NME1 gene is associated with metastasis in epithelial ovarian cancer
JA Leary, J Kerr, G Chenevix-Trench, CP Doris, T … - Int J Cancer, 1995 - ncbi.nlm.nih.gov
... Allele loss at 5 other chromosome 17 loci (D17S5, TP53, NF1, D17S74, D17S4)
was also evaluated for many of these 76 patients. Allele ...
Cited by 13 - Web Search - Get it from MIT Libraries

Cancer-related gene expression profiles in NF1-associated pilocytic astrocytomas - Full text - MIT Libraries
J Li, A Perry, CD James, DH Gutmann - Neurology, 2001 - neurology.org
... sporadic JPA 19,20 and the recent studies in which mice carrying a targeted disruption
of both the NF1 and TP53 genes developed high-grade astrocytomas, 21 we ...
Cited by 8 - Web Search - neurology.org - neurology.org - ncbi.nlm.nih.gov

Malignant melanoma in patients with multiple endocrine neoplasia type 1 and involvement of the MEN 1 … - Full text - MIT Libraries
B Nord, A Platz, K Smoczynski, S Kytoelae, G … - International Journal of Cancer, 2000 - doi.wiley.com
... In addition, cytogenetic and molecular studies of sporadic melanoma have implicated
the tumor suppressors TP53 and NF1, as well as several chromosomal regions ...
Cited by 12 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

[CITATION] Ranzani GN, Pierotti MA, Pilotti S. Rb and TP53 pathway alterations in sporadic and NF1-related … - Full text - MIT Libraries
S Birindelli, F Perrone, M Oggionni, C Lavarino, B … - Lab. Invest, 2001
Cited by 2 - Web Search

Correlation between clinicopathological features and karyotype in spindle cell sarcomas - Full text - MIT Libraries
CDM Fletcher, P Dal Cin, I de Wever, N Mandahl, F … - Am J Pathol, 1999 - ajp.amjpathol.org
... been focused on the frequency with which chromo- somal regions harboring potentially
relevant tumor sup- pressor genes (especially TP53 on 17p and NF1 on 17q ...
Cited by 37 - Web Search - ajp.amjpathol.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Molecular analysis of astrocytomas presenting after age 10 in individuals with NF1 - Full text - MIT Libraries
DH Gutmann, CD James, M Poyhonen, DN Louis, R … - NEUROLOGY, 2003 - intl.neurology.org
... 15 The finding of a TP53 mutation provides the first evidence that mutational events
in NF1 and TP53 can occur in human NF1-associated brain tumors. ...
Cited by 3 - Web Search - neurology.org - intl.neurology.org - ncbi.nlm.nih.gov - all 5 versions »

Comparative FISH-mapping of six expressed gene loci to river buffalo and sheep chromosomes
SK Davis, JF Taylor - Cytogenet Cell Genet, 1999 - content.karger.com
... Four (NF1, CRYB1, TP53 and P4HB) of the six genes map- ped by the current authors,
were assigned for the first time to OAR 11, extending the sheep physical map ...
Cited by 7 - Web Search - content.karger.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Physical assignment of six type I anchor loci to bovine chromosome 19 by fluorescence in situ … - Full text - MIT Libraries
DS Gallagher, YP Yang, JD Burzlaff, JE Womack, DM … - Animal Genetics, 1998 - ingentaconnect.com
... chromosome 19 (BTA19). Six out of eight loci were identified in the BAC library
(NF1, CRYB1, CHRNB1, TP53, GH1 and P4HB). The BACs were ...
Cited by 14 - Web Search - animalgenomics.missouri.edu - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Nf1; Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects - Full text - MIT Libraries
KM Reilly, DA Loisel, RT Bronson, ME McLaughlin, T … - Nat Genet, 2000 - nature.com
... Alterations of the TP53 gene in human gliomas. ... astrogliosis in brains of mice
heterozygous for mutations in the neurofibromatosis type 1 (Nf1) tumor suppressor ...
Cited by 60 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Chromosome 17 allelic loss in astrocytic tumors and its clinico-pathologic implications.
AK Muhammad, T Yoshimine, M Maruno, K Tokiyoshi, O … - Clin. Neuropathol, 1997 - ncbi.nlm.nih.gov
... LOH was observed in 11/19 (58%) instances with frequent involvement of TP53, NF1,
and D17S795 loci, LOH at D17S578 and D17S520 occurred in recurrent tumors ...
Cited by 1 - Web Search - Get it from MIT Libraries

Allelic Loss of the NF1 Gene in NF1-Associated Plexiform Neurofibromas-a review of the clinical … - Full text - MIT Libraries
L Kluwe… - Cancer Genetics and Cytogenetics, 1999 - ingentaconnect.com
... of the NF1 gene, is associated with the development of plexiform neurofibromas.
The 14 plexiform neufibromas were also examined for mutation in the TP53 gene ...
Cited by 30 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Syndromic aspects of testicular carcinoma
MFL Holzik, RH Sijmons, DT Sleijfer, DJA Sonneveld … - Cancer, 2003 - doi.wiley.com
... No testicular tumors were found in knock-out mice for TP53, NF1, p16, VHL,
and a range of other known tumor-suppressor genes. 41 ...
Cited by 1 - Web Search - med.rug.nl

Research Review Cancer Genetics - Full text - MIT Libraries
H PREDISPOSITION - American Journal of Medical Genetics, 2002 - doi.wiley.com
... Others, like RB1, TP53, NF1, and Wilms tumor 1 (WT1), may be mutant in the germline,
imparting cancer susceptibility to heterozygotes, or be mutated ...
Web Search

P53 mutations in sporadic and NF1 related malignant peripheral nerve sheath tumors (MPNST): from …
M Ferrone, S Pricl, MS Paneni, E Tamborini, S … - caslab.units.it
... B. Vergani, GN Ranzani, MA Pierotti and S. Pilotti, Rb and TP53 pathway alterations
in sporadic and NF1-related malignant peripheral nerve sheath tumors, Lab. ...
View as HTML - Web Search

Elevated risk for MPNST in NF1 microdeletion patients - Full text - MIT Libraries
T De Raedt, H Brems, P Wolkenstein, D Vidaud, S … - Am J Hum Genet, 2003 - journals.uchicago.edu
... F, Oggionni M, Lavarino C, Pasini B, Vergani B, Ranzani GN, Pierotti MA, Pilotti
S (2001) Rb and TP53 pathway alterations in sporadic and NF1-related malignant ...
Cited by 19 - Web Search - pubmedcentral.nih.gov - journals.uchicago.edu - ncbi.nlm.nih.gov - all 5 versions »

Benign neurofibromas in type 1 neurofibromatosis(NF 1) show somatic deletions of the NF 1 gene
SD Colman, CA Williams, MR Wallace - Nature Genetics, 1995 - nature.com
... The Mspl polymorphism in intron 6 of p53 (TP53) detected by digestion of PCR products.
Nucl. ... Refined physical map of the NF1 region on chromosome 17. Am. ...
Cited by 94 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Construction of a bovine Chromosome 19 linkage map with an interspecies hybrid backcross - Full text - MIT Libraries
YP Yang, JE Womack - Mammalian Genome, 1997 - springerlink.com
... 4). The chromosome is divided into five conserved regions, with TP53 and CHRNB1
in region I, NF1 and CRYB1 in region II, myeloperoxidase (MPO) in region III ...
Cited by 13 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

RAS, FLT3, and TP53 mutations in therapy-related myeloid malignancies with abnormalities of …
LE Side, NP Curtiss, K Teel, C Kratz, PW Wang, RA … - Genes Chromosomes Cancer, 2004 - doi.wiley.com
... lines was available from two of the remaining patients, both of which also showed
a single allele at each polymorphic NF1 locus. SSCP analysis of TP53 exons 5 ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Brain tumours: classification and genes - Full text - MIT Libraries
VP Collins - Journal of Neurology Neurosurgery & Psychiatry - dx.doi.org
... Molecular genetic studies have been few and have shown allelic losses on
both 17p and 17q including the TP53 and NF1 loci. Few TP53 ...
Web Search - jnnp.com - jnnp.bmjjournals.com - ncbi.nlm.nih.gov - all 5 versions »

Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate … - Full text - MIT Libraries
HA Kim, B Ling, N Ratner - Mol. Cell. Biol, 1997 - mcb.asm.org
... Nf1-Deficient Mouse Schwann Cells Are Angiogenic and ... We have developed a potential
model of Schwann cell tumor formation in neurofibromatosis type 1 (NF1). ...
Cited by 50 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Familial neurofibromatosis microdeletion syndrome complicated by rhabdomyosarcoma - Full text - MIT Libraries
AK Lampe, G Seymour, PW Thompson, A Toutain, SA … - Archives of Disease in Childhood, 2002 - adc.bmjjournals.com
... NF1 neurocristopathy. Inactivation of both NF1 genes and/or TP53 has been
shown in NF1 associated malignancies. Several models of ...
Cited by 4 - Web Search - adc.bmjjournals.com - dx.doi.org - ncbi.nlm.nih.gov

Detailed chromosomal and radiation hybrid mapping in the proximal part of rat Chromosome 10 and gene … - Full text - MIT Libraries
A Behboudi, L Roshani, M Kost-Alimova, E Sj& x 000 … - Mammalian Genome, 2002 - springerlink.com
... RNO10 harbors many important cancer-related genes, including several well-known
tumor suppressor genes such as Tsc2, Irf1, Tp53, Nf1, and Brca1 (Yasue et al. ...
Cited by 6 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Unusual clustering of brain tumors in a family with NF1 and variable expression of cutaneous … - Full text - MIT Libraries
F Faravelli, M Upadhyaya, M Osborn, SM Huson, R … - J Med Genet, 1999 - jmedgenet.com
... 23 In addition, an abnormal TP53 allele would be unlikely to cosegregate with the
abnormal NF1 allele in the numerous family members reported here. ...
Cited by 1 - Cached - Web Search - jmedgenet.com - jmg.bmjjournals.com - ncbi.nlm.nih.gov

Oligo GEArray® Human Neurotrophin and Receptors Microarray
S Conditions - search.cosmobio.co.jp
... Cell cycle: BAX, BCL2, F2, FGF2, FGF9, IL1B, MYC, NF1, PTN, STAT1, TGFA,
TGFB1, TP53. Cell proliferation: BCL2, CCKBR, ETS1, FGF2 ...
View as HTML - Web Search

Minor lesion mutational spectrum of the entire NF1 gene does not explain its high mutability but … - Full text - MIT Libraries
R Fahsold, S Hoffmeyer, C Mischung, C Gille, C … - Am J Hum Genet, 2000 - dx.doi.org
... 1995), 45% 50% of TP53 point mutations in colorectal cancer (Greenblatt et ... Likewise,
overlap between pseudogene sequence variants and NF1 germline mutations as ...
Cited by 62 - Web Search - journals.uchicago.edu - charite.de - ncbi.nlm.nih.gov - all 5 versions »

Plexiform neurofibromas in NF1 - Full text - MIT Libraries
RJ Packer, DH Gutmann, MD PhD, A Rubenstein, D … - Neurology, 2002 - neurology.org
... Birindelli S, Perrone F, Oggionni M, et al. Rb and TP53 pathway alterations in sporadic
and NF1-related malignant peripheral nerve sheath tumors. Lab Invest . ...
Cited by 13 - Web Search - intl.neurology.org - neurology.org - ncbi.nlm.nih.gov - all 5 versions »

Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral …
A Perry, SN Kunz, CE Fuller, R Banerjee, EF Marley … - J Neuropathol Exp Neurol, 2002 - jneuropath.com
... Birindelli S, Perrone F, Oggionni M, et al. Rb and TP53 pathway alterations in sporadic
and NF1-related malignant peripheral nerve sheath tumors. ...
Cited by 11 - Web Search - neur.allenpress.com - apt.allenpress.com - ncbi.nlm.nih.gov - all 7 versions » - Get it from MIT Libraries

Nervous system: Peripheral nerve sheath tumors
C Morphological, C Molecular - caroll.vjf.cnrs.fr
... in embryonic lethality. However, mice with heterozygous germline mutations
of both Nf1 and Tp53 develop MPNST. This animal model ...
Cached - Web Search

Chromosome 17 loss-of-heterozygosity studies in benign and malignant tumors in neurofibromatosis …
SA Rasmussen, J Overman, SAM Thomson, SD Colman, … - Genes Chromosomes and Cancer, 2000 - doi.wiley.com
... tumors. The losses in the plexiform tumors all included sequences distal
to NF1. No subtle TP53 mutations were found in any tumors. ...
Cited by 30 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Clonal origin and expansions in neoplasms: biologic and technical aspects must be considered … - Full text - MIT Libraries
L Pozo-Garcia, SJ Diaz-Cano - Am J Pathol, 2003 - ajp.amjpathol.org
... Wolfe HJ, Diaz-Cano SJ: Kinetic profiles by topographic compartments in muscle-invasive
transitional cell carcinomas of the bladder: role of TP53 and NF1 genes ...
Cited by 1 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Screening 500 unselected neurofibromatosis 1 patients for deletions of the NF1 gene. - Full text - MIT Libraries
L Kluwe, R Siebert, S Gesk, RE Friedrich, S … - Hum Mutat, 2004 - doi.wiley.com
... mutations analysis, especially for large genes such as the NF1 gene with ... Screening
for TP53 rearrangements in families with the Li-Fraumeni syndrome reveals a ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov

Tumor Suppressor Mutations and Growth Factor Signaling in the Pathogenesis of NF1-Associated …
SL Carroll, MS Stonecypher - Journal of Neuropathology and Experimental Neurology - jneuropath.com
... TP53 mutations are frequent in malignant NF1 tumors. ... Rb and TP53 pathway alterations
in sporadic and NF1-related malignant peripheral nerve sheath tumors. ...
Cited by 1 - Web Search - neur.allenpress.com - apt.allenpress.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Human chromosome 17 comparative anchor loci are conserved on bovine chromosome 19 - Full text - MIT Libraries
YP Yang, JE Womack - Genomics, 1995 - ncbi.nlm.nih.gov
... Eight comparative anchor loci on human chromosome 17, TP53, CHRNB1, THRA1, CRYB1,
NF1, MPO, MYL4, and P4HB, were mapped to bovine chromosome 19 using bovine x ...
Cited by 12 - Web Search - ncbi.nlm.nih.gov

Aberrant CpG island methylation in neurofibromas and neurofibrosarcomas - Full text - MIT Libraries
P Gonzalez-Gomez, MJ Bello, D Arjona, ME Alonso, J … - ONCOLOGY REPORTS, 2003 - 147.52.72.117
... 11. Legius E, Dierick H, Wu R, Hall BK, Marynen P, Cassiman JJ and Glover
TW: TP53 mutations are frequent in malignant NF1 tumours. ...
Cited by 5 - View as HTML - Web Search - virology.med.uoc.gr - biotools.net - ncbi.nlm.nih.gov

Initiation of human astrocytoma by clonal evolution of cells with progressive loss of p53 functions … - Full text - MIT Libraries
G Fulci, N Ishii, D Maurici, KM Gernert, P Hainaut … - Cancer Res, 2002 - intl-cancerres.aacrjournals.org
... Initiation of Human Astrocytoma by Clonal Evolution of Cells with Progressive Loss
of p53 Functions in a Patient with a 283H TP53 Germ-line Mutation. ...
Cited by 6 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Loss of heterozygosity(LOH), malignancy grade and clonality in microdissected prostate cancer - Full text - MIT Libraries
A Huegel, N Wernert - British Journal of Cancer, 1999 - nature.com
... D18S543 D17S855 D8S87 Chromosaml loci Grade 1 Grade 2 Grade 3 RB DCC TP53
BBC1 NF2 NF1 BRCA1 can WT1 AT M E-cad DCC BRCA1 DCC Figure 2 ...
Cited by 16 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Malignant Peripheral Nerve Sheath Tumor: A Comparison of Grade, Immunophenotype, and Cell Cycle/ …
H Zhou, CM Coffin, SL Perkins, SR Tripp, M Liew, … - Am J Surg Pathol, 2003 - ajsp.com
... 17 Comparison of p53 protein expression and TP53 mutations between NF1-related and
sporadic MPNSTs revealed that the TP53 mutation, loss of heterozygosity ...
Cited by 3 - Web Search - ajsp.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

TP53, P14 ARF, P16 INK4A AND H-RAS GENE MOLECULAR ANALYSIS IN INTESTINAL-TYPE ADENOCARCINOMA OF THE … - Full text - MIT Libraries
I Milan - Int. J. Cancer, 2003 - doi.wiley.com
Page 1. TP53, P14 ARF , P16 INK4A AND H-RAS GENE MOLECULAR ANALYSIS IN
INTESTINAL-TYPE ADENOCARCINOMA OF THE NASAL CAVITY AND PARANASAL SINUSES ... III – TP53, ...
Web Search

Loss of heterozygosity analysis of mouse pulmonary adenomas induced by coal tar - Full text - MIT Libraries
F Benavides, CJ Conti, M LaCava, M Flores, E … - Environmental and Molecular Mutagenesis, 2003 - doi.wiley.com
... and differentiation. Both genes have homologs (TP53 and NF1) on human
chromosome 17 (17p13 and 17q11, respectively). Our findings ...
Web Search - ncbi.nlm.nih.gov - csa.com