Transfection of melanoma cells with antisense PAX3 oligonucleotides additively complements cisplatin … - Full text - MIT Libraries
SJ He, G Stevens, AW Braithwaite, MR Eccles - Mol Cancer Ther, 2005 - mct.aacrjournals.org
... explain the increased percentage of p53-positive cells, thereby implicating a possible
role for PAX3 in transcriptionally repressing TP53, quantitative real ...
Web Search - mct.aacrjournals.org - ncbi.nlm.nih.gov

A novel and consistent amplicon at 13 q 31 associated with alveolar rhabdomyosarcoma
AT Gordon, C Brinkschmidt, J Anderson, N Coleman, … - Genes Chromosomes and Cancer, 2000 - doi.wiley.com
... of 17p seen here in 10% of cases could be associated with loss of function/mutation
of TP53 (Felix et al ... PAX3/7-FKHR fusion gene status by RT-PCR and int FISH ...
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Isolation and chromosomal assignment of canine genomic BAC clones representing 25 cancer-related … - Full text - MIT Libraries
R Thomas, W Bridge, K Benke, M Breen, F Alert - Cytogenetic and Genome Research, 2003 - content.karger.com
... MDM2, RAF1, RB1, ERBB2), or with existing DNA or mRNA sequence for the canine gene
where those data are available (MYB, SAS, PAX3, KIT, BRCA1, TP53, WT1, MYC ...
Cited by 1 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »

Genomic gains and losses are similar in genetic and histologic subsets of rhabdomyosarcoma, whereas …
JA Bridge, J Liu, SJ Qualman, R Suijkerbuijk, G … - Genes Chromosomes and Cancer, 2002 - doi.wiley.com
... These translocations create the chimeric genes PAX3-FKHR and PAX7-FKHR ...
Immunohistochemistry TP53 immunostaining was performed using monoclonal mouse antihuman ...
Cited by 12 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Genes, chromosomes, and rhabdomyosarcoma
J Anderson, A Gordon, K Pritchard-Jones, J Shipley - Genes Chromosomes and Cancer, 1999 - doi.wiley.com
... The fusion genes are thought critically to affect downstream targets of PAX3 and
PAX7 ... 5 and disruption of genes such as IGF2, ATR, PTC, P16, and TP53 have also ...
Cited by 39 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Mechanisms of sarcoma development - Full text - MIT Libraries
LJ Helman, P Meltzer - Nature Reviews Cancer, 2003 - nature.com
... First identification of germline mutations of TP53 in families with Li-Fraumeni
syndrome. ... The PAX3-FKHR fusion protein created by the t(2;13) translocation in ...
Cited by 12 - Web Search - nature.com - ncbi.nlm.nih.gov

Unusual case of leukemic mantle cell lymphoma with amplifiedCCND 1/IGH fusion gene
AM Gruszka-Westwood, S Atkinson, BM Summersgill, J … - Genes Chromosomes and Cancer, 2002 - doi.wiley.com
... TP53 mutations in exon 5 have been described in aggres- sive MCL cases (Gandini
et al ... t(1; 13)(p36;q14) or more rarely amplification of PAX3/ FKHR associated ...
Cited by 7 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Novel genomic imbalances in embryonal rhabdomyosarcoma revealed by comparative genomic hybridization …
JA Bridge, J Liu, V Weibolt, KS Baker, D Perry, R … - Genes Chromosomes and Cancer, 2000 - doi.wiley.com
... with previous descriptions of frequent allelic loss of 17p (TP53) in E ... These
translocations create the following chimeric genes, respectively: PAX3-FKHR and ...
Cited by 31 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

HEREDITARY BACKGROUND IN BONE AND SOFT-TISSUE TUMOURS
O PRESENTATION - taylorandfrancis.metapress.com
... TP53 mutation status has also been detected by other authors, reflecting the existence
of ... characterized by the fusion of FKHR at 13q14 with either PAX3 at 2q35 ...
Web Search - taylorandfrancis.metapress.com

Molekularbiologie maligner Tumorerkrankungen - Full text - MIT Libraries
A Prozess, Z leitet eine neue Phase, E fuer die … - Der Onkologe - springerlink.com
... Rundzelltumor des Abdomen) Malignes Melanom der Weichteile t(12;22)(p13;q12)
PAX3-FKH ... 8 Ausschnitt aus der direkten Sequenzanalyse von Exon 8 des TP53-Gens.Im ...
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Survivin-directed RNA interference cocktail is
JM Genet - jmg.bmjjournals.com
... FKHR translocation,[26] whereas RH28 and RH30 cells are characterized by a
PAX3;FKHR translocation.[27] All four lines also harbor non- functional TP53 proteins ...
Web Search

Poster sessions
DNA PLOIDY, PAIN PROSTATIC, ACIN FNAB, N … - Analytical Cellular Pathology, 2003 - iospress.metapress.com
... than Dukes’ B. Moreover, the incidence of mutations of the KRAS2 and TP53 genes
was ... A.15 METHYLATION OF THE HUMAN PAX3 UPSTREAM REGION IN RHABDOMYOSARCOMAS ...
Web Search

Preclinical experimental therapeutic approaches in soft tissue sarcoma
KK Hunt, BW Feig - Seminars in Surgical Oncology, 1999 - doi.wiley.com
... S, Fredericks WJ, Rauscher FJ 3 rd , et al: The hybrid PAX3- FKHR fusion ... E, Drobnjak
M, Pollack D, et al: Chromosome 17 abnor- malities and TP53 mutations in ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Loss of heterozygosity and p53 polymorphism Pro72Arg in a young patient with medulloblastoma - Full text - MIT Libraries
I SARDI, L GIUNTI, P DONATI, L LACITIGNOLA, F … - ONCOLOGY REPORTS, 2003 - 147.52.72.117
... TP53 analysis was performed by PCR amplification using corresponding gene- specific
primer sets (8 ... G, Haworth A and Kumar S: The mutation status of PAX3 and p53 ...
View as HTML - Web Search - virology.med.uoc.gr - ncbi.nlm.nih.gov

alanek na vzvu–pfiehled
IPMMV AVZBROJ, AVFA PATHOLOGIST - linkos.cz
... metoda je pouze orientaãní, pro detailní anal˘zu je nutná sekve- nace genu TP53. ...
4a,b) au alveolárních rabdomyosarkomÛ – t(2;13) sgeny PAX3/FKHR at(1 ...
View as HTML - Web Search - linkos.cz

A canine cancer-gene microarray for CGH analysis of tumors - Full text - MIT Libraries
R Thomas, H Fiegler, EA Ostrander, F Galibert, NP … - Cytogenetic and Genome Research, 2003 - content.karger.com
... 003 424 TP53 5q21 032 335 CFA 13 13q13 061 767 RB1 22q11.2 ... 016 646 CFA 11
11q12.3–q13 045 671 CFA 14 14q14 074 453 PAX3 37q16–q17 ...
Cited by 5 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »

Genetic and molecular abnormalities in tumors of the bone and soft tissues - Full text - MIT Libraries
GD Letson, CA Muro-Cacho - Cancer Control, 2001 - moffitt.usf.edu
... Alveolar rhabdomyosarcoma t(2;13)(q35;q14) PAX3-FKHR 39, 40 ... by its own unique cytoge-
netic profile without apparent involvement of the TP53 or MDM2 genes. ...
Cited by 7 - View as HTML - Web Search - issoonline.com - issoonline.com - ncbi.nlm.nih.gov - all 5 versions »

Chromosome aberrations in solid tumors - Full text - MIT Libraries
DG Albertson, C Collins, F McCormick, JW Gray - Nature Genetics, 2003 - nature.com
... TP53 status and gene amplification in human colorectal carcinomas. ... Fusion of a fork
head domain gene to PAX3 in the solid tumour alveolar rhabdomyosarcoma. ...
Cited by 53 - Web Search - nature.com - cc.ucsf.edu - ncbi.nlm.nih.gov - all 5 versions »

Mapping of novel regions of DNA gain and loss by comparative genomic hybridization in esophageal … - Full text - MIT Libraries
L Du Plessis, E Dietzsch, M Van Gele, N Van Roy, P … - Cancer Res, 1999 - cancerres.aacrjournals.org
... The two cases with high level amplification on 13q exclude the PAX3 locus, and this ...
ie, on 9p (MTS1/CDKN2), 11p (WT1, KAI1), 13q (RB1), 17p (TP53), and 17q ...
Cited by 23 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

Genetic and expression profiles of cerebellar liponeurocytomas. - Full text - MIT Libraries
S Horstmann, A Perry, G Reifenberger, F … - Brain Pathol, 2004 - brainpath.medsch.ucla.edu
... DNA sequencing revealed TP53 missense mutations in 4 (20%) of 20 cerebellar
liponeurocytomas, a frequency higher than in medulloblastomas. ... TP53 mutations. ...
Cited by 1 - View as HTML - Web Search - ijp-online.com - ijp-online.com - ncbi.nlm.nih.gov

TUMEURS DE LA VERGE
ICE ET, IPAR HPV - urofrance.org
... Li-Fraumeni (syndrome Autosomique 17p13.1 (TP53) Sarcomes des tissus mous, cancers
OMIM ... fusion des gènes PAX3 (2q35) et FKHR (13q14) dans le premier cas, PAX7 ...
View as HTML - Web Search

Adenovirus-mediated p 53 gene therapy in pediatric soft-tissue sarcoma cell lines: sensitization to …
H Ganjavi, M Gee, A Narendran, MH Freedman, D … - Cancer Gene Therapy, 2005 - nature.com
... 8–10 Most translocations involve fusion of the FKHR gene with the gene for the
transcription factor PAX3 which is on chromosome 2 (t(2;13)(q35;q14)). ...
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Profiling and functional annotation of mRNA gene expression in pediatric rhabdomyosarcoma and Ewing' … - Full text - MIT Libraries
C Baer, M Nees, S Breit, B Selle, AE Kulozik, KL … - International Journal of Cancer, 2004 - doi.wiley.com
... Most aRMS express PAX3-FKHR or PAX7-FKHR fusion proteins re- sulting from
[t(2;13)(q35;q14)] or [t(1;13)(p36;q14)] transloca- tions, respectively. ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Genetics of Beckwith-Wiedemann Syndrome-Associated Tumors: Common Genetic Pathways
BW SYNDROME - GENES, CHROMOSOMES & CANCER, 2000 - doi.wiley.com
... Two other groups identified mutations in the TP53 gene in around 30% of sporadic
ACCs ... In the case of the t(2;13), a PAX3-FKHR fusion product is expressed (Barr ...
Web Search - doi.wiley.com

Cytosine methylation and mammalian development - Full text - MIT Libraries
CP Walsh, TH Bestor - Genes Dev, 1999 - genesdev.org
... tested sites in DNA of sperm, whereas the other four (Hoxb4, Lep, Pax3, and Oxtr ...
Magewu and Jones (1994) found that an exon of the TP53 gene that is especially ...
Cited by 141 - Web Search - genesdev.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 7 versions »

Molecular biology of sarcomas: update-the cell cycle paradigm
RL Randall, SL Lessnick, B Johnson, DE Joyner - Current Opinion in Orthopaedics, 2004 - co-orthopedics.com
... a splice-variant p16 gene product, blocks the inactivation of TP53 by MDM2 ... alveolar
rhabdomyosarcoma, the t(2;13)(q35;q14) fuses the PAX3 homeobox transcription ...
Web Search

Molecular Genetics of Pediatric Soft Tissue Tumors
D Applications - Journal of Molecular Diagnostics, 2003 - jmd.amjpathol.org
... Embryonal Gains of 2, 7, 8, 12, 13; losses of 1, 6, 9, 14, and 17 50 IGF2, GOK,
PTCH TP53 NA NA NA Good Alveolar t(2;13)(q35;q14); PAX3-FKHR 75% Ref.67 Ref.13 ...
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BMC Bioinformatics - Full text - MIT Libraries
SD Mooney, TE Klein - BMC Bioinformatics, 2002 - biomedcentral.com
... CASR 1.42 GNAS1 0.67 PAH 0.69 TAT 0.52 CAV3 0.70 GP1BA 1.08 PAX3 0.86 TGFBI 0.55
CBS 0.57 GP9 0.66 PAX6 0.99 TH 0.84 ... CRB1 0.01 HPRT1 0.90 PLP1 0.82 TP53 0.28 ...
View as HTML - Web Search - bmc.ub.uni-potsdam.de - gdrs-intranet.ath.cx - smi-web.stanford.edu - all 6 versions »

New developments in the pathology of skull base tumors - Full text - MIT Libraries
H Radner, D Katenkamp, G Reifenberger, M Deckert, … - Virchows Archiv, 2001 - springerlink.com
... Page 7. cytomas generally lack mutations in the NF2 and TP53 genes but do carry
homozygous CDKN2A deletions in about 25% of the cases [34, 59]. ...
Cited by 9 - Web Search - ncbi.nlm.nih.gov

The Application of DNA Microarrays to the Study of Cancer
K Harshman, M Sanchez-Carbayo - Current Genomics, 2002 - ingentaconnect.com
... Targets of the PAX3-FKHR and EGR1 Oncogenes The muscle cancer alveolar rhabdomyosarcoma
(ARMS) is often associated with a chromosomal translocation that fuses ...
Web Search

Genetics of Soft Tissue Tumors
J Lasota - elsevierinternational.com
... 83 t(12;22)(q13;q12) EWS-CHOP Rhabdomyosarcoma, alveolar t(2;13)(q35;q14)
PAX3-FKHR 101–104 t(1;13)(p36;q14) PAX7-FKHR Synovial ...
View as HTML - Web Search - harcourt-international.com - elsevier-international.com - intl.elsevierhealth.com - all 6 versions »

Cytogenetics and the surgeon: an invaluable tool in diagnosis, prognosis and counselling of patients … - Full text - MIT Libraries
GME Humphrey, R Squire, M Lansdown, A Markham, K … - Br J Surg, 1998 - doi.wiley.com
... Li-Fraumeni syndrome Breast cancer Sarcomas Adrenal cortical carcinoma TP53* 17
106 ... Alveolar rhabdomyosarcoma t(2;13)(q35;q14) t(1;13)(p36;q14) PAX3-FKHR PAX7 ...
Cited by 1 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Increased p 53 immunopositivity in anaplastic medulloblastoma and supratentorial PNET is not caused … - Full text - MIT Libraries
C Eberhart, A Chaudhry, R Daniel, L Khaki, K Shah, … - BMC Cancer, 2005 - pubmedcentral.nih.gov
... M, Malone G, Haworth A, Kumar S. The mutation status of PAX3 and p53 ... The TP53-ARF
tumor suppressor pathway is frequently disrupted in large/cell anaplastic ...
Web Search - citebase.eprints.org - biomedcentral.com - dx.doi.org - all 7 versions »

Tumor Suppressor Gene Regulation of Cell Growth
EJ Uhlmann, DH Gutmann - Cell Biochemistry and Biophysics, 2001 - neurosci.humanapress.com
... Individuals with germline muta- tions in the TP53 or RB genes demonstrate
an increased susceptibility to malignancy. Children with ...
Cited by 1 - Web Search - now.humanapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions » - Get it from MIT Libraries

Myeloid- and lymphoid-specific breakpoint cluster regions in chromosome band 13 q 14 in acute …
LJA Coignet, CSP Lima, T Min, B Streubel, J … - Genes Chromosomes and Cancer, 1999 - doi.wiley.com
... of tumor suppressor genes in hematologic malignan- cies include TP53 g at ... pediatric
alveolar rhabdomyosarcoma juxtaposes PAX3 on chromosome 2 with the forkhead ...
Cited by 13 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Gains of 1q21–q22 and 13q12–q14 are potential indicators for resistance to cisplatin-based … - Full text - MIT Libraries
K Kudoh, M Takano, T Koshikawa, M Hirai, S Yoshida … - Clin Cancer Res, 1999 - intl-clincancerres.aacrjournals.org
... gene encodes a transcription factor that fuses with the transcription activator
PAX3 and acts as ... synthetase on 6p12 or loss of the regions for the TP53 gene on ...
Cited by 19 - Web Search - intl-clincancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

p oeehled
SKKCNIP EHLEDNOVĚ, J CH, A POSTUPŮ, T APPROACHES - linkos.cz
... Tato translokace vede k zlomu genu PAX3 na chromosomu 2 a jeho juxtapozici do oblasti
vlivu dosud málo probádaného transkripčníhofaktoruFKHR(ALV ...
View as HTML - Web Search - linkos.cz

Molecular approaches to sarcoma therapy
RJ Olsen, SR Tarantolo, SH Hinrichs - Sarcoma, 2002 - dx.doi.org
... sarcoma Tumor type Molecular alteration Involved genes Alveolar t(2;13)(q35;
q14) PAX3/FKHR Rhabdomyosarcoma t(1;13)(p36;q14) PAX7/FKHR ...
Cited by 1 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ingentaconnect.com

BMC Cancer - Full text - MIT Libraries
CG Eberhart, A Chaudhry, RW Daniel, L Khaki, KV … - BMC Cancer, 2005 - bmc.ub.uni-potsdam.de
... Schwarz M, Malone G, Haworth A, Kumar S: The mutation status of PAX3 and p53 ... Lindsey
JC, Lusher ME, Fuller CE, Clifford SC, Gilbertson RJ: The TP53-ARF tumor ...
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1 translocation, Transmission of an unbalanced (Y; 1) translocation - Full text - MIT Libraries
A ATM - atherosclerosis - jmg.bmjjournals.com
... mapping, A cryptic deletion of 2q35 including part of the PAX3 gene detected by ... breast
and ovarian cancer families, 611 Low rate of TP53 germline mutations in ...
Web Search

Evolution by Phenotype - Full text - MIT Libraries
KM Weiss, AV Buchanan - Perspectives in Biology and Medicine, 2003 - muse.jhu.edu
... TP53 (colon, other cancers)1,300 CFTR (cystic fibrosis) 1,001 LDL receptor (heart ...
Pax6 (eye problems) 115 TSD (Tay-Sachs disease) 91 Pax3 (hearing, pigmentation ...
Web Search - anthro.psu.edu - anthro.psu.edu - muse.jhu.edu

Cytogenetics of cranial base tumors
SM Gollin, IP Janecka - Journal of Neuro-Oncology, 1994 - springerlink.com
... the localiza- tion and isolation of several tumor suppressor genes, including RB1,
TP53 [8], DCC ... at(2;13)(q35;q14) results in alteration of the PAX3 paired box ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

6 RECURRING CHROMOSOME REARRANGEMENTS IN HUMAN CANCER
OI Olopade, OM Sobulo, JD Rowley - cancer.org
Page 1. Acquired clonal chromosomal abnormalities are found in the malignant cells
of most patients with leukemia, lymphoma, and solid tumors. ...
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[BOOK] Molecular genetic studies on human sarcomas
M Wolf - 2000 - ethesis.helsinki.fi
... THBS1 gene for thrombospondin 1 TOP3 gene for topoisomerase III TP53 gene for ... 11
Recently, cDNA microarray studies have indicated that the PAX3/FKHR fusion ...
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Allelic genes of blood group antigens: A source of human mutations and cSNPs documented in the Blood … - Full text - MIT Libraries
OO Blumenfeld, SK Patnaik - Human Mutation, 2004 - doi.wiley.com
Page 1. DATABASES Allelic Genes of Blood Group Antigens: A Source of Human Mutations
and cSNPs Documented in the Blood Group Antigen Gene Mutation Database ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Update on genetic events in the pathogenesis of melanoma
S Halachmi, BA Gilchrest - Curr Opin Oncol, 2001 - co-oncology.com
... Ringborg U: Screening of germline mutations in the CDK4, CDKN2C and TP53 genes in ...
J, Novotna H: Expression of genes for microphthalmia isoforms, Pax3 and MSG1 ...
Cited by 9 - Web Search - co-oncology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Comparative map between the domestic pig and dog - Full text - MIT Libraries
LS Biltueva, F Yang, NV Vorobieva, AS Graphodatsky - Mammalian Genome, 2004 - springerlink.com
... p1.2–qter 5 17p13–p11.2 TP53: HSA17p13–CFA5–SSC12q12–14 ... q2.3–q2.5 33 2q33–37
PAX3: HSA2q36–CFA33–SSC15q25; SLC11A1: HSA2q35–CFA33–SSC15q23 ...
Web Search - ncbi.nlm.nih.gov

Cytogenetics and molecular pathology in cancer diagnostics
S Knuutila - Annals of Medicine, 2004 - dx.doi.org
... t(2;5)(p23;q35)/ ALK;NPM1 NHLAnaplastic large T-cell t(2;13)(q35;q14)/ PAX3;FOXO1A
Alveolar rhabdomyosarcoma Small round cell tumor ... (del(17p13)/TP53) CLL Poor ...
Cited by 1 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

SIAPEC IAP Societa Italiana International Academy di Anatomia Patologica e of Pathology …
B Board, GI di Immunoistochimica, GI di Patologia - springerlink.com
Page 1. 339 Page 2. SIAPEC IAP Società Italiana International Academy di Anatomia
Patologica e of Pathology Citopatologia Diagnostica Italian Division ...
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Origin and evolution of avian microchromosomes - Full text - MIT Libraries
DW Burt, FTC Alert - Cytogenetic and Genome Research, 2002 - content.karger.com
Page 1. Cytogenet Genome Res 96:97–112 (2002) Origin and evolution of
avian microchromosomes DW Burt Department of Genomics and ...
Cited by 21 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »