Frequent inactivation of CDKN2A and rare mutation of TP53 in PCNSL - Full text - MIT Libraries
JM Cobbers, M Wolter, J Reifenberger, GU Ring, F … - Brain Pathol, 1998 - ncbi.nlm.nih.gov
... one T-cell lymphoma) were investigated for genetic alterations and/or expression
of the genes BCL2, CCND1, CDK4, CDKN1A, CDKN2A, MDM2, MYC, RB1, REL, and TP53. ...
Cited by 25 - Web Search - ncbi.nlm.nih.gov

Frequent Inactivation of CDKN2A and Rare Mutation of TP53 in PCNSL - Full text - MIT Libraries
C CDKN1A, MYC MDM, REL RB - Brain Pathology, 1998 - brainpathology.com
... T-cell lym- phoma) were investigated for genetic alterations and/or expression of
the genes BCL2, CCND1, CDK4, CDKN1A, CDKN2A, MDM2, MYC, RB1, REL, and TP53. ...
Web Search - brainpath.medsch.ucla.edu

Prognostic Impact of TP53 Mutation Status for Adult Patients with Supratentorial World Health …
ALT Analysis - doi.wiley.com
... Page 6. DISCUSSION It has been confirmed that TP53 mutations are rel- atively common
early events in the pathogenesis of WHO Grade II astrocytomas and ...
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High frequency of TP53 mutations in juvenile pilocytic astrocytomas indicates role of TP53 in the … - Full text - MIT Libraries
VM Hayes, CM Dirven, A Dam, E Verlind, WM Molenaar … - Brain Pathol, 1999 - brainpathology.com
... Figure 1. Aberrant DGGE banding patterns for all TP53 mutations found in 20 ...
Abbreviations used are as follows; c, control, and B, rel- evant brain tumor. ...
Cited by 14 - Web Search - brainpath.medsch.ucla.edu - brainpath.medsch.ucla.edu - ncbi.nlm.nih.gov

Activation of nuclear factor kappaB in radioresistance of TP53-inactive human keratinocytes - Full text - MIT Libraries
X Chen, B Shen, L Xia, A Khaletzkiy, D Chu, JY … - Cancer Res, 2002 - cancerres.aacrjournals.org
... Tumor Biology. Activation of Nuclear Factor B in Radioresistance of TP53-inactive
Human Keratinocytes 1. ... 3. NF- B, but not TP53, was activated in HK18-IR cells. ...
Cited by 20 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

TP53 polymorphisms and haplotypes in South Amerindians and neo-Brazilians
PA Gaspar, MH Hutz, FM Salzano, TA Weimer - Ann Hum Biol, 2001 - dx.doi.org
... The genotype and allele frequency distributions of the three TP53 polymorphisms
are ... pairwise haplotype frequencies, as well as D and D rel values obtained for ...
Cited by 4 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Sequence variation database project at the European Bioinformatics Institute - Full text - MIT Libraries
H Lehvaeslaiho, E Stupka, M Ashburner - Human Mutation, 2000 - doi.wiley.com
... TABLE 1. Cross-References Between the Two TP53 Database Entries Link type
v.2/rel.1997 v.3/rel.1999 Unique links from P53 to 5,440 7,034 P53B Unique entries ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov

A limited role for TP53 mutation in the transformation of follicular lymphoma to diffuse large B- …
AJ Davies, AM Lee, C Taylor, AJ Clear, LK Goff, S … - Leukemia, 2005 - nature.com
... chain reaction and comparative genomic hybridization to identify amplification of
the REL gene in ... 22. Guimaraes DP, Hainaut P. TP53: a key gene in human cancer ...
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Serum anti-p 53 antibodies and prognosis of patients with small-cell lung cancer - Full text - MIT Libraries
M Rosenfeld, N Malats, L Schramm, F Graus, F … - Journal of the National Cancer Institute, 1997 - jncicancerspectrum.oupjournals.org
... Mutations of the p53 tumor suppressor gene (also known as TP53) are among the ... issue
of whether these antibod- ies are clinically or physiologically rel- evant. ...
Cited by 22 - Web Search - jncicancerspectrum.oupjournals.org - ncbi.nlm.nih.gov

GEArray S Series Human Immunology Signaling Pathways Gene Array: AR-SAHS-605
FG Grouping, A Molecules, I ICAM, CS Molecules, C … - eurogentec.com
... IκB Family: NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIL1, NFKBIL2, NFRKB, REL, RELA, RELB. ...
NFKB2, NFKBIB, NFKBIE, NR4A2, PCNA, RAF1, RELA, RPS6KA5, SP1, SP3, TP53. ...
View as HTML - Web Search - eurogentec.be

Inhibition of NF-B, clonogenicity, and radiosensitivity of human cancer cells - Full text - MIT Libraries
F Pajonk, K Pajonk, WH McBride - J. Natl. Cancer Inst.(Bethesda), 1999 - jncicancerspectrum.oupjournals.org
... cludes activation of transcription factors, such as AP-1, p53 (also known as TP53),
and NF ... and het- erodimers of its subunits p50, p52, p65/ RelA, c-Rel, and Rel ...
Cited by 41 - Web Search - strahlenbiologie.bei.t-online.de - ingentaconnect.com - ncbi.nlm.nih.gov

Intronic deletion affecting a negative regulatory region of TP73 is related to breast and colorectal …
C Pena, JM Garcia, G Dominguez, J Silva, V Garcia, … - GENES, CHROMOSOMES & CANCER, 2004 - doi.wiley.com
... studies (Stiewe et al., 2002), and the fact that, unlike Tp53 ( / ) mice, Tp73 ... TP73
RNAm levels were calculated using a rel- ative quantification approach in ...
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Amplification of IGH/MYC Fusion in Clinically Aggressive IGH/BCL2-Positive Germinal Center B-Cell …
JI Martıno, MD Odero, R Hernandez, JC Cigudosa, X … - GENES, CHROMOSOMES & CANCER, 2005 - doi.wiley.com
... The second case harbored a duplication of REL and acquired a translocation affecting
IGL and a biallelic inactivation of TP53 during progression. ...
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Chromosomal imbalances in primary lymphomas of the central nervous system - Full text - MIT Libraries
CH Rickert, B Dockhorn-Dworniczak, R Simon, W … - Am J Pathol, 1999 - ajp.amjpathol.org
... patients, found CDKN2A deletions in 50% but detected no amplifications for CDK4,
CCND1, BCL2, MDM2, MYC or REL, and only one case showed a TP53 mutation. ...
Cited by 20 - Web Search - ajp.amjpathol.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

核因子 κB 的信号转导机制及研究策略
巨立中, 成军, 钟彦伟 - wjgnet.com
... Activators and target genes of Rel/NF-KapaaB tran- scription factors. ... Activation
of nuclear KB in radioresistance of TP53-inac- tive human keratinocytes. ...
View as HTML - Web Search - wjgnet.com - wjgnet.com - wjgnet.com

Isolation and chromosomal assignment of canine genomic BAC clones representing 25 cancer-related … - Full text - MIT Libraries
R Thomas, W Bridge, K Benke, M Breen, F Alert - Cytogenetic and Genome Research, 2003 - content.karger.com
... annotated DNA or mRNA data for the corre- sponding human gene (REL, FES, FOS, NF1 ...
gene where those data are available (MYB, SAS, PAX3, KIT, BRCA1, TP53, WT1, MYC ...
Cited by 1 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »

Insights into the multistep transformation process of lymphomas: IgH-associated translocations and …
R Schmitz, C Renne, R Rosenquist, M Tinguely, V … - Leukemia, 2005 - nature.com
... of NF- B, that is NFKBIA (I B ) or by amplification of the REL gene. 10, 11, 12,
13, 14 Contrary to this, mutations in the tumor suppressor genes TP53 and FAS ...
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Short Communication
CH Rickert, B Dockhorn-Dworniczak, R Simon, W … - American Journal of Pathology, 1999 - ajp.amjpathol.org
... patients, found CDKN2A deletions in 50% but detected no amplifications for CDK4,
CCND1, BCL2, MDM2, MYC or REL, and only one case showed a TP53 mutation. ...
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Similar patterns of genomic alterations characterize primary mediastinal large-B-cell lymphoma and …
N Palanisamy, AA Abou-Elella, SR Chaganti, J … - Genes Chromosomes and Cancer, 2002 - doi.wiley.com
... of alterations affecting the BCL1, BCL2, BCL6, MYC, RASH, RASN, and TP53 genes in ...
One study suggested that amplification of REL and gain of Xq, 9p, and 12q may ...
Cited by 22 - Web Search - gis.nus.edu.sg - gis.a-star.edu.sg - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

Microsatellite instability analysis in typical and progressed mantle cell lymphoma and B-cell … - Full text - MIT Libraries
L Sanz-Vaque, D Colomer, F Bosch, A Lopez- … - Haematologica, 2001 - haematologica.it
... Rel- atively indolent and aggressive forms of MCL may be identified; these are ... D8S254
8p22 Unknown NM23 17q21 NM23-H1 D18S35 18q21 DCC TP53-Dint 17p13 p53 ...
Cited by 6 - View as HTML - Web Search - haematologica.org - haematologica.org - ncbi.nlm.nih.gov - all 10 versions »

Antioncogenes and human cancer - Full text - MIT Libraries
AG Knudson - Proc Natl Acad Sci USA, 1993 - pnas.org
... and endocrine Carcinoma Cloned RBI 13q14 Sarcoma Retinoblastoma WTI 11p13
Wilms tumor TP53 17pl3 Sarcoma Glioma Breast NFl 17qll ...
Cited by 232 - Web Search - pnas.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Unusual case of leukemic mantle cell lymphoma with amplifiedCCND 1/IGH fusion gene
AM Gruszka-Westwood, S Atkinson, BM Summersgill, J … - Genes Chromosomes and Cancer, 2002 - doi.wiley.com
... 4B). Direct sequencing of all 11 exons of TP53 was executed by PCR amplification
of ... in lymphomas include: BCL2 (Monni et al., 1997) and REL proto- oncogene ...
Cited by 7 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

[CITATION] Recent advances in the understanding of aggressive B-cell lymphomas
A Jack, S Barrans
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Overexpression of cyclin A overrides the effect of p53 alterations in breast cancer patients with … - Full text - MIT Libraries
IRK Bukholm, A Husdal, JM Nesland, A Langeroed, G … - Breast Cancer Research and Treatment, 2003 - kluweronline.com
... in patients without p53 abnormalities, while hole line shows rel- ative survival
in ... correlation between the overexpression of cyclin A and TP53 gene mutations ...
Cited by 1 - Web Search - springerlink.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Classification, pathogenesis and molecular pathology of primary CNS lymphomas
W Paulus - Journal of Neuro-Oncology, 1999 - springerlink.com
... p16 25 12 (48%) Homozygous deletion CDKN2B/p15 5 3 Homozygous deletion TP53/p53
25 3 (12%) Point mutation (codons 52, 175, 248) cdk4 20 0 mdm2 20 0 rel 20 0 bcl ...
Cited by 20 - Web Search - kluweronline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Timeline: Analysing differential gene expression in cancer - Full text - MIT Libraries
P Liang, AB Pardee - Nature Reviews Cancer, 2003 - nature.com
... family, is a mediator of the antiapoptotic activity of the v-Rel oncoprotein. ... Isolation
of a novel TP53 target gene from a colon cancer cell line carrying a ...
Cited by 11 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The Bowman Birk protease inhibitor enhances clonogenic cell survival of ionizing radiation treated … - Full text - MIT Libraries
KH Dittmann, E Dikomey, C Mayer, HP Rodemann - Int J Radiat Biol, 2000 - dx.doi.org
... TP53-mediated processes—involving the activation ... FDR = f rel /( f plug +f rel ),
where f plug and f rel corre- of DNA released decreased exponentially and ...
Cited by 4 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

Molecular Cancer - Full text - MIT Libraries
GE Lind, RI Skotheim, MF Fraga, VM Abeler, R … - Molecular Cancer, 2005 - bmc.ub.uni-potsdam.de
... unstable (MSI) colon cancer cell lines and primary colon carcinomas (25 MSS and
28 MSI) with known ploidy stem line and APC, KRAS, and TP53 mutation status, we ...
View as HTML - Web Search - bmc.ub.uni-potsdam.de - folk.uio.no

Radiation-Induced Changes of Telomerase Activity in a Human Ewing Xenograft Tumor - Full text - MIT Libraries
A Schuck, C Poremba, C Lanvers, S K& x 000 F 6 … - Strahlentherapie und Onkologie, 2002 - springerlink.com
... It shows a chromosomal t(11/22) translocation EWS-FLI1 (type I) and a TP53 exon
6 mutation [1, 5, 7 ... 2.00 1.80 1.60 1.40 1.20 1.00 0.80 0.60 0.40 0.20 0.00 Rel. ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

p53 Abnormalities in Primary Prostate Cancer: Single-Strand Conformation Polymorphism Analysis of … - Full text - MIT Libraries
DNA Genomic - J Natl Cancer Inst, 1997 - jncicancerspectrum.oupjournals.org
... Mutations in the p53 gene (also known as TP53) are found in human ... fragments contained
sequence alter- ations, RT–PCR products from the rel- evant regions of ...
Cited by 22 - Web Search - jncicancerspectrum.oupjournals.org - ncbi.nlm.nih.gov

Accuracy of Cancer Family Histories: Comparison of Two Breast Cancer Syndromes
KA Schneider, LM DiGianni, AF Patenaude, N Klar, … - Genetic Testing, 2004 - dx.doi.org
... eligi- bility for genetic testing among HBOCS historians, but fewer than half of
LFS historians provided informa- tion that would have led to TP53 testing. ...
Web Search - liebertonline.com - liebertonline.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Pattern of Secondary Genomic Changes in Pancreatic Tumors of Tgf/Trp53/Transgenic Mice
B Schreiner, DM Baur, AA Fingerle, U Zechner, FR … - GENES, CHROMOSOMES & CANCER, 2003 - doi.wiley.com
... proximal part spans about 16 cM, including the genes for Egfr, Rel, and Stk10. ... These
in- clude deletion or inactivation of CDKN2A, TP53, and MADH4, which have ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

BIOINFORMATICS - Full text - MIT Libraries
Y Lai, B Wu, L Chen, H Zhao - BIOINFORMATICS, 2004 - bioinformatics.oupjournals.org
... By using tumor suppressor genes TP53, PTEN and RB1, we identify seven genes that ...
hetero-dimers formed from the multigene family of RelA (p65), c-Rel, RelB, NF ...
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The role of G2-block abrogation, DNA double-strand break repair and apoptosis in the … - Full text - MIT Libraries
T Theron, A Binder, F Verheye-Dua, L Bohm - Int J Radiat Biol, 2000 - taylorandfrancis.metapress.com
... 4197, and the TP53 mutant cell lines MeWo and 4451 (table 1). ... for the dose range
10–100Gy are given in gure 3. Fractions of DNA released (F rel ) were were ...
Cited by 15 - Web Search - ncbi.nlm.nih.gov

Response of malignant B lymphocytes to ionizing radiation: Gene expression and genotype - Full text - MIT Libraries
H Lyng, KS Landsverk, E Kristiansen, PM DeAngelis, … - International Journal of Cancer, 2005 - doi.wiley.com
... from Oncogene Research Products (San Diego, CA; clone 1801 anti-TP53, clone EA10
anti ... The table also contains data for the rel- ative expression of unirradiated ...
Web Search - ncbi.nlm.nih.gov

Expression of p 53, glutathione S-transferase-pi, and Bcl-2 proteins and benefit from adjuvant … - Full text - MIT Libraries
R Silvestrini, S Veneroni, E Benini, MG Daidone, A … - Journal of the National Cancer Institute, 1997 - jncicancerspectrum.oupjournals.org
... Another marker of putative rel- evance as a prognostic indicator (17) (and ... To confirm
preliminary results on the relationship between TP53 status and re ...
Cited by 37 - Web Search - upload.mcgill.ca - jgh.ca - ncbi.nlm.nih.gov - all 7 versions »

Genomic imbalances including amplification of the tyrosine kinase gene JAK2 in CD30 Hodgkin cells - Full text - MIT Libraries
S Joos, M Kupper, S Ohl, F von Bonin, G … - Cancer Res, 2000 - cancerres.aacrjournals.org
... b) the members of the REL/NF- B family of transcription factors, REL (2p15) and ... myeloma
(17) ; and (d) MDM2 (12q14), which is a potent inhibitor of TP53 and is ...
Cited by 38 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

Homozygous deletions of CDKN2A caused by alternative mechanisms in various human cancer cell lines.
S Raschke, V Balz, T Efferth, WA Schulz, AR Florl - GENES, CHROMOSOMES & CANCER, 2005 - doi.wiley.com
... P16 INK4A RT-PCR b P14 ARF1 RT-PCR b HPV status b TP53 mutation c ... environment, the
40-kb region en- compassing the CDKN2A and CDKN2B loci is rel- atively poor ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased … - Full text - MIT Libraries
S Rocha, AM Martin, DW Meek, ND Perkins - Mol. Cell. Biol, 2003 - mcb.asm.org
... The RSV RelA (p65), p50, and c-Rel expression plasmids have been previously described ...
Total RNA was extracted from H1299 w/tp53 cells by using the RNeasy kit ...
Cited by 21 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

p 53 in Mammary Ductal Carcinoma In Situ, Mutations in High-Grade Lesions Only? - Full text - MIT Libraries
JF Simpson, DL Page, ME Edgerton - Journal of the National Cancer Institute, 2001 - jncicancerspectrum.oupjournals.org
... Dissecting the contribution that mutated p53 (also known as TP53) makes to ... of case
patients, with analysis occurring within clinically rel- evant categories of ...
Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

[CITATION] Modulation of radiosensitivity of thyroid cancer cells by inhibition of NF-κB signaling
DV Starenki, H Namba, VA Saenko, A Ohtsuru, S …
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GEArray Q Series Human Cancer Drug Resistance & Metabolism Gene Array: AR-SAHS-019
FG Grouping - eurogentec.com
... BAX, BCL2, BCL2L1 (bcl-x), MVP (LRP), RB1, TOP1, TOP2A, TOP2B, TP53 (p53 ... MAFB, MYC
(c-myc), NFKB1, NFKB2, NFKBIB (TRIP9), NFKBIE, RELB (l-rel), TNFRSF11A (Rank ...
View as HTML - Web Search - eurogentec.be

Nuclear factor-[kappa] B as a predictor of treatment response in breast cancer.
AK Garg, GN Hortobagyi, BB Aggarwal, AA Sahin, TA … - Current Opinion in Oncology-, 2003 - co-oncology.com
... Rayet B, Gelinas C: Aberrant rel/nfkb genes and activity in human cancer. ... Overgaard
J, Yilmaz M, Guldberg P, et al.: TP53 mutation is an independent prognostic ...
Cited by 1 - Web Search - co-oncology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

A sporadic breast tumor with a somatically acquired complex genomic rearrangement in BRCA1
M van der Looij, AM Cleton-Jansen, R van Eijk, H … - Genes Chromosomes Cancer, 2000 - doi.wiley.com
... Immunohistochemical staining with anti- bodies against TP53 and HER2/NEU remained
negative ... mammary gland during puberty but has no functional rel- evance after ...
Cited by 10 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

EXPLORING CONCEPT SPACES FOR TEXT MINING
AK Sehgal - cs.uiowa.edu
... BMPR1A MADH4 PTEN KCNE1 AFP TP53 BRCA2 ARMET ABCA4 ACADVL PXF PEX10 PXR1 SCN4A
ABCC6 Table 3.2: Gene groups. Rel.: related, Unrel.: unrelated. ...
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Metastatic medulloblastoma—therapeutic success through molecular target identification?
MC Fruehwald, C Plass - The Pharmacogenomics Journal, 2002 - nature.com
... 5 Due to its prognostic rel- ... such as the forma- tion of an isochromosome 17q and
a loss of heterozygosity distal to 17p13.1 (distal to the TP53 locus) have ...
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A novel and consistent amplicon at 13 q 31 associated with alveolar rhabdomyosarcoma
AT Gordon, C Brinkschmidt, J Anderson, N Coleman, … - Genes Chromosomes and Cancer, 2000 - doi.wiley.com
... coma, and the loss of 17p seen here in 10% of cases could be associated with loss
of function/mutation of TP53 (Felix et al ... 110 dia and rel, indicate diagnosis ...
Cited by 16 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

CT, USA
Y Lai, B Wu, L Chen, H Zhao - bioinformatics.med.yale.edu
... Using tumor suppressor genes TP53, PTEN, and RB1, we identify seven genes that also ...
dimers formed from the multigene family of RelA (p65), c-Rel, RelB, NF-kB1 ...
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Frequent silencing of fragile histidine triad gene(FHIT) in Burkitt's lymphoma is associated with …
A Hussain, MI Gutierrez, G Timson, AK Siraj, C … - Genes Chromosomes and Cancer, 2004 - doi.wiley.com
... equally between those carrying mutant TP53 and those carrying wild-type TP53. ... 1),
with two potential mechanisms rel- evant to FHIT inactivation assessed. ...
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Special Article
AM Reappraisal - American Journal of Pathology, 2001 - hms.harvard.edu
... 8 –13 The glioma path- way that includes TP53 inactivation is ... 5 For anaplastic
oligodendrogliomas, the therapeutic rel- evance of molecular subtyping is ...
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