Further evidence that germline CEBPA mutations cause dominant inheritance of acute myeloid leukaemia …
GS Sellick, HE Spendlove, D Catovsky, K Pritchard- … - Leukemia, 2005 - nature.com
... We have previously excluded involvement of Fanconi, mutations in TP53 and RUNX1
and linkage to 16q21−23.2 as a cause of AML in the family. 3, 4. Figure 1. ...
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Centromeric breakage and highly rearranged chromosome derivatives associated with mutations of TP53 …
MK Andersen, DH Christiansen, J Pedersen-Bjergaard - GENES, CHROMOSOMES & CANCER, 2005 - doi.wiley.com
... point on 21q22 was shown to be centromeric of the RUNX1 gene with an ... chromosomes
previously had been investigated for mutations of the TP53 gene (Christiansen ...
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Role of multiplex FISH in identifying chromosome involvement in myelodysplastic syndromes and acute … - Full text - MIT Libraries
E Barouk-Simonet, V Soenen-Cornu, C Roumier, A … - Cancer Genet Cytogenet, 2005 - ncbi.nlm.nih.gov
... Complementary FISH helped us identify involvement of TP53, MLL, and RUNX1/AML1 genes
in 82% of cases, confirming their probable role in leukemogenesis. ...
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Loci other than 21 q 22. 12(RUNX 1) and 16 q 21–23. 2 cause familial AML
GS Sellick, K Pritchard-Jones, V Shepherd, J … - Leukemia, 2005 - nature.com
... 2 In addition to RUNX1, linkage analysis has implicated chromosome 16q21−23.2 as
a ... We have previously excluded involvement of Fanconi and mutations in TP53. ...
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A novel gene, MSI2, encoding a putative RNA-binding protein is recurrently rearranged at disease … - Full text - MIT Libraries
A Barbouti, M Hoglund, B Johansson, C Lassen, PG … - Cancer Res, 2003 - cancerres.aacrjournals.org
... have mostly focused on well-known tumor suppressor genes (eg, TP53, CDKN2A, and ...
AML-associated translocations/fusion genes, eg, t(3;21)(q26;q22)/RUNX1-EVI1, t(7 ...
Cited by 8 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - lu-research.lub.lu.se - all 5 versions »

Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses … - Full text - MIT Libraries
CD Baldus, S Liyanarachchi, K Mrozek, H Auer, SM … - Proceedings of the National Academy of Sciences, 2004 - pnas.org
... using different probes specific for the APP, ERG, ETS2, and RUNX1 genes ... TP53 was
significantly underexpressed in the five AML cases with complex karyotypes and ...
Cited by 5 - Web Search - pubmedcentral.nih.gov - knm1.ibe.med.uni-muenchen.de - dx.doi.org - all 9 versions »

A Literature Based Method for Identifying Gene-Disease Connections
LA Adamic, D Wilkinson, BA Huberman, E Ada - CSB, 2002 - dx.doi.org
... we can also find that the probability that 480 or more RUNX1 documents are ... factor
1 (breast cancer, estrogen-inducible sequence expressed in) TP53 P53, TRP53 ...
Cited by 12 - Web Search - ieeexplore.ieee.org - doi.ieeecomputersociety.org - doi.ieeecs.org - all 10 versions »

RNA interference as a potential tool in the treatment of leukaemia
A Borkhardt, O Heidenreich - Expert Opinion on Biological Therapy, 2004 - extenza-eps.com
... [37] . However, TP53 mutations in leukaemia are associated with a poor therapeutic
prognosis. ... Senescence BC R- AB L T EL–PDGFR β mut. p53 RUNX1 CBFA2T1 ...
Web Search - ashley-pub.com - dx.doi.org - ingentaconnect.com - all 8 versions »

Diagnostic value of fluorescence in situ hybridization for the detection of genomic aberrations in … - Full text - MIT Libraries
S Froehling, S Kayser, C Mayer, S Miller, C … - Haematologica, 2005 - haematologica.org
... 17p– K0189 17p13 TP53 RZPD 20q– 808_c_5 20q12 D20S99 CEPH +21q 464_h_8/72_h_9 21q22
RUNX1 CEPH +22q 361_d_9 22q11 BCR CEPH Xq– IE018 Xq28 DXS304 RZPD ...
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Diagnostic application of FISH to hematological malignancies.
V Najfeld - CANCER INVESTIGATION, 2003 - taylorandfrancis.metapress.com
... The disruption of the AML-1 (RUNX1) gene is associated with the development ... frequently
affects the short arm of chromosome 17, where the TP53 tumor suppressor ...
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Development of a human acute myeloid leukaemia screening panel and consequent identification of …
ML Smith, R Arch, LL Smith, N Bainton, M Neat, C … - ingentaconnect.com
... and TP53, for example, occur in 5–10% of cases of AML but predominate in ... Similarly,
RUNX1 mutation occurs at a frequency of 5% but has a higher incidence in ...
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Novel loss-of-function mutations of the haematopoiesis-related transcription factor, acute myeloid … - Full text - MIT Libraries
M Nakao, S Horiike, Y Fukushima-Nakase, M … - Br J Haematol, 2004 - ingentaconnect.com
... AML1/RUNX1, which encodes a transcription factor essential for definitive
haematopoiesis ... deletion of chromosome 12p, or inactivation of TP53 accompanied some ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

research paper Novel loss-of-function mutations of the haematopoiesis-related transcription factor, …
M Nakao, S Horiike, Y Fukushima-Nakase, M … - blackwell-synergy.com
... AML1/RUNX1, which encodes a transcription factor essential for definitive
haematopoiesis ... deletion of chromosome 12p, or inactivation of TP53 accompanied some ...
Web Search

Acquired mutations in GATA 1 in the megakaryoblastic leukemia of Down syndrome - Full text - MIT Libraries
J Wechsler, M Greene, MA McDevitt, J Anastasi, JE … - Nature Genetics, 2002 - nature.com
... In vitro analyses of known and novel RUNX1/AML1 mutations in dominant ... a recurring
abnormality in malignant myeloid disorders associated with mutations of TP53. ...
Cited by 68 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Analysis of the interaction of TIP60β and PIN1 with the ets family transcription factor ETV6
CD Zhang - edoc.ub.uni-muenchen.de
... kinase such as PDGFRβ, JAK2, or transcription factors such as RUNX1 or ... SYK, and
FGFR3, to transcription factors, such as AML1/RUNX1, EVI1, ...
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Haploinsufficiency for tumor suppression: The hazards of being single and living a long time - Full text - MIT Libraries
DA Largaespada - J Exp Med, 2001 - dx.doi.org
... sufficiently strong as to render cells functionally null (as with many TP53 mutations ...
which may also share this characteristic, are P27KIP1 and AML1/RUNX1 (2) (3 ...
Cited by 8 - Web Search - jem.org - intl.jem.org - ncbi.nlm.nih.gov - all 5 versions »

Research Paper Development of a human acute myeloid leukaemia screening panel and consequent … - Full text - MIT Libraries
ML Smith, R Arch, LL Smith, N Bainton, M Neat, C … - British Journal of Haematology, 2005 - blackwell-synergy.com
... Mutations of KIT, CEBPA and TP53, for example, occur in 5 10% of cases of ... Similarly,
RUNX1 mutation occurs at a frequency of 5% but has a higher incidence in ...
Web Search

Towards the identification of new markers of pancreatic cancer by gene expression analysis.
R Summary - john-libbey-eurotext.fr
... KRAS2 (95 % de mutations), les gènes suppresseurs CDKN2A (p16), TP53 et MADH4 ... la
transcription de l’ADN (topoisomérase II, ARNTL2, RUNX1), réparation de l ...
Cached - Web Search - john-libbey-eurotext.fr

Vers l’identification de nouveaux marqueurs du cancer du pancreas par l’analyse du transcriptome
R Summary, C Rosty - john-libbey-eurotext.fr
... KRAS2 (95 % de mutations), les gènes suppresseurs CDKN2A (p16), TP53 et MADH4 ... la
transcription de l’ADN (topoisomérase II, ARNTL2, RUNX1), réparation de l ...
Cached - Web Search

Making waves in cancer research: new models in the zebrafish
S Berghmans, C Jette, D Langenau, K Hsu, R Stewart … - BioTechniques, 2005 - biotechniques.com
... Stable trans- genic zebrafish lines expressing the RUNX1-CBF2T1 fusion protein and ...
that successfully used TILLING to identify two zebrafish tp53 mutant lines ...
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Vers l’identification de nouveaux marqueurs du cancer du pancreas par l’analyse du transcriptome
C Rosty - Bull Cancer, 2004 - john-libbey-eurotext.fr
... KRAS2 (95 % de mutations), les gènes suppresseurs CDKN2A (p16), TP53 et MADH4 ... la
transcrip- tion de l’ADN (topoisomérase II, ARNTL2, RUNX1), répara- tion ...
View as HTML - Web Search - john-libbey-eurotext.fr

Loss of RUNX3 Expression Significantly Affects the Clinical Outcome of Gastric Cancer Patients and … - Full text - MIT Libraries
D Wei, W Gong, SC Oh, Q Li, WD Kim, L Wang, X Le, … - Cancer Research, 2005 - cancerres.aacrjournals.org
... in the l3 loop and LSH motif DNA-binding domains of TP53 predict poor ... Potential roles
for RUNX1 and its orthologs in determining hematopoietic cell fate. ...
Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov

Mutations of AML1 are common in therapy-related myelodysplasia following therapy with alkylating … - Full text - MIT Libraries
DH Christiansen, MK Andersen, J Pedersen-Bjergaard - Blood, 2004 - bloodjournal.org
... In vitro analyses of known and novel RUNX1/AML1 mutations in dominant ... TP53 mutations
emerge at early phase of myelodysplastic syndrome and are associated with ...
Cited by 6 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov - all 5 versions »

Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers - Full text - MIT Libraries
A Goel, CN Arnold, P Tassone, DK Chang, D … - Int. J. Cancer, 2004 - doi.wiley.com
... RUNX1 is an indispensable factor in hematopoiesis and angiogenesis, and anomalies
in ... In CRCs, for example, TP53 is most often inactivated by point mutation and ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of … - Full text - MIT Libraries
M Kochetkova, OL McKenzie, AJ Bais, JM Martin, GA … - Cancer Res, 2002 - cancerres.aacrjournals.org
... translocation t(8;21) that also results in a fusion protein with RUNX1. ... Loss of
well-characterized tumor suppressors, such as TP53, PTEN, and others, or ...
Cited by 10 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - corbettresearch.com - all 5 versions »

Analysis of Myelodysplastic Syndromes with Complex Karyotypes by High-Resolution Comparative Genomic …
A Martınrez, M Urioste, L Melchor, D Blesa, L … - GENES, CHROMOSOMES & CANCER, 2005 - doi.wiley.com
... the TP53 gene in 25% of cases, and homogeneously staining regions with mild
amplification levels (more than 10 copies) involving the ERBB2, MLL, and RUNX1 genes ...
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Cytogenetics and molecular pathology in cancer diagnostics
S Knuutila - Annals of Medicine, 2004 - dx.doi.org
... t(8;21)(q22;q22) CBFA2T1(ETO); RUNX2(CBFA1), RUNX1(AML1) AMLM2 Leukemic tumors
more common than typically ... (del(17p13)/TP53) CLL Poor prognosis ...
Cited by 1 - Web Search - taylorandfrancis.metapress.com - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

A second field metachronous Merkel cell carcinoma of the lip and the palatine tonsil confirmed by … - Full text - MIT Libraries
JNLZF Istvan, SJLBI Laszlo, G Puskas - Virchows Arch, 2005 - springerlink.com
... 16p13–12 ASC TSC2 16q24 WFDC1, GAS8, MGC15419, CBFA2T3 17p13 TP53, HIC1, OVCA2 ... MRVI1
14q31–32 SIVA 16q23–24 (LOC145908) CBFA2T3 21q22.13 RUNX1 22q11 BID ...
Web Search - ncbi.nlm.nih.gov

Growth Factors and Oncogenes in Gastrointestinal Cancers
E Tahara - media.wiley.com
... About 50% of esophageal SCC harbor mutations of the Tp53 gene, most of which are
missense mutations leading to amino acid changes within ex- ons 5–8, which ...
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Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden …
K Mrozek, K Heinonen, KS Theil, CD Bloomfield - Genes Chromosomes and Cancer, 2002 - doi.wiley.com
... of three balanced aberrations recognized by G-banding and identified another nine
balanced aberrations, including a novel translocation involving the RUNX1 gene ...
Cited by 18 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Original Research Report
ESC Differentiation - dx.doi.org
... ACTA1; ACTA2; ALPL; CD34; CD9; KDR; MYH11; MYH6; MYL4; PECAM1; RUNX1; RUNX2; VCAM1 ...
MDM2; PIGPC1; PIM1; PIR5A; PTEN; RBBP6; RB1; RBL1; RBL2; TP53; XRCC5 ACRV1 ...
Web Search - liebertonline.com - liebertonline.com

Hematopoietic perturbation in zebrafish expressing a tel-jak2a fusion.
SM Onnebo, MM Condron, DO McPhee, GJ Lieschke, AC … - Experimental Hematology, 2005 - eanimal.snu.ac.kr
... in acute myeloid leukemia, reproduced the hematological consequences observed in
RUNX1-CBF2T1 knock ... 7. Parant JM, Lozano G. Disrupting TP53 in mouse models of ...
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EXPLORING CONCEPT SPACES FOR TEXT MINING
AK Sehgal - cs.uiowa.edu
... CHIC2 NUP214 RUNX1 HNF4A BFSP2 COL5A2 COL1A1 COL5A1 IRF1 ALAD LAMC2 COL17A1 LAMA3
SSX2 PON2 BMPR1A MADH4 PTEN KCNE1 AFP TP53 BRCA2 ARMET ABCA4 ACADVL ...
View as HTML - Web Search - cs.uiowa.edu

Mining MEDLINE for Similar Genes and Similar Drugs
P Srinivasan, AK Sehgal - The Ninth ACM SIGKDD International Conference on Knowledge … - mingo.info-science.uiowa.edu
... CHIC2 NUP214 RUNX1 HNF4A BFSP2 COL5A2 COL1A1 COL5A1 IRF1 ALAD LAMC2 COL17A1 LAMA3
SSX2 PON2 BMPR1A MADH4 PTEN KCNE1 AFP TP53 BRCA2 ARMET ABCA4 ACADVL ...
Cited by 1 - View as HTML - Web Search - cs.uiowa.edu - mingo.info-science.uiowa.edu

Molecular mechanisms of breast cancer progression: lessons from mouse mammary cancer models and gene …
Y Ye, TH Qiu, C Kavanaugh, JE Green - Breast Disease, 2004 - iospress.metapress.com
... muscle), MHC class II DP-β1 and the transcription factor RUNX1 (unique to ... PR or other
growth factor receptors, histological grade, erbB2 and TP53 status, are ...
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Gene Expression Profiles of BRCA1-Linked, BRCA2-Linked, and Sporadic Ovarian Cancers - Full text - MIT Libraries
AA Jazaeri, CJ Yee, C Sotiriou, KR Brantley, J … - Journal of the National Cancer Institute, 2002 - jncicancerspectrum.oupjournals.org
... BRCA1 tumors expressed higher levels of RUNX1/ AML1, whereas BRCA2-associated samples
preferentially ... 5) that have a high incidence of TP53 mutations (13,45). ...
Cited by 44 - Web Search - math.wm.edu - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Spectral karyotyping and fluorescence in situ hybridization detect novel chromosomal aberrations, a … - Full text - MIT Libraries
E Hilgenfeld, H Padilla-Nash, N McNeil, T Knutsen, … - British Journal of Haematology, 2001 - blackwell-synergy.com
... t(8;21), which detects the first five exons of the AML1 (RUNX1) gene (encompassing ...
aberrations detected led to loss of 17p and, therefore, loss of TP53 at 17p13 ...
Cited by 17 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Terminal osteoblast differentiation, mediated by runx2 and p27 KIP1, is disrupted in osteosarcoma - Full text - MIT Libraries
DM Thomas, SA Johnson, NA Sims, MK Trivett, JL … - J. Cell Biol, 2004 - jcb.org
... mutated in human leukemia, and mice expressing loss-of-function runx1 mutants are ...
carcinogen exposure (Fero et al., 1998) or mutations to TP53 (Philipp-Staheli ...
Cited by 4 - Web Search - dx.doi.org - jem.org - ncbi.nlm.nih.gov - all 5 versions »

Gonadotropin-induced gene regulation in human granulosa cells obtained from IVF patients: Modulation … - Full text - MIT Libraries
E Rimon, R Sasson, A Dantes, A Land-Bracha, A … - Int J Oncol, 2004 - 147.52.72.117
Page 1. Abstract. Gonadotropins play a crucial role in ovarian homeostasis
and fertilization. However, hypergonadotropin stimulation ...
Cited by 4 - View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Multicolor karyotyping in acute myeloid leukemia
J Tchinda, S Volpert, N McNeil, T NEUMANN, I … - Leuk Lymphoma, 2003 - taylorandfrancis.metapress.com
... In these cases, the copy number gain of the RUNX1 (AML1) gene did not correlate
with the amount of 21q material gained, excluding this gene as the target of ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Multicolor Karyotyping in Acute Myeloid Leukemia
J TCHINDA, S VOLPERT, N McNEIL, T NEUMANN, I … - Leukemia & Lymphoma, 2003 - dx.doi.org
... In these cases, the copy number gain of the RUNX1 (AML1) gene did not correlate
with the amount of 21q material gained, excluding this gene as the target of ...
Web Search

G ENETICS OF M YELOID L EUKEMIAS - Full text - MIT Libraries
LM Kelly, DG Gilliland - Annual Review of Genomics and Human Genetics, 2002 - genom.annualreviews.org
... CBF is a heterodimeric transcription factor composed of a DNA-binding component,
AML1 (also known by the HUGO designation RUNX1, CBFA2, and PEBP2A), and the ...
Cited by 35 - Web Search - 128.194.251.107 - fluid.annualreviews.org - ncbi.nlm.nih.gov - all 5 versions »

Pathogenesis of acute myeloid leukaemia and inv (16)(p 13; q 22): a paradigm for understanding … - Full text - MIT Libraries
JT Reilly - British Journal of Haematology, 2005 - blackwell-synergy.com
... is a family of heterodimeric transcription factors containing a common subunit
(CBF ) and one of three CBF subunits, CBF 1, AML1 (also known as RUNX1 or CBF 2 ...
Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Comprehensive genotypic analysis of leukemia: clinical and therapeutic implications
L Kelly, J Clark, DG Gilliland - Curr. Opin. Oncol, 2002 - co-oncology.com
... discovered (Table 2). AML1 TOP. AML1 (also known as RUNX1, CBFA2) is a frequent
target of translocations in human leukemias. It has ...
Cited by 11 - Web Search - siteman.wustl.edu - co-oncology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

AML1 interconnected pathways of leukemogenesis
J Michaud, HS Scott, R Escher - Cancer Invest, 2003 - taylorandfrancis.metapress.com
... AML1, also called CBFa2, PEBPa2 or RUNX1, is thus implicated in a great number of
acute leukemias via a variety of pathogenic mechanisms and seems to act ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Array-based comparative genomic hybridization for the detection of DNA sequence copy number changes … - Full text - MIT Libraries
B Albrecht, M Hausmann, H Zitzelsberger, H Stein, … - The Journal of Pathology, 2004 - doi.wiley.com
... TOP1 NCOA3(AIB1) MYBL2 CSE1L(CAS) PTPN1 STK6(STK15) ZNF217(ZABC1) CYP24 TNFRSF 6B
(DCR3) TPD52L2,TOM 200TEL14 D21S378 RUNX1(AML1) DYRK1A ... TP53(p53) PAFAH1B1(LIS1 ...
Cited by 2 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

Mechanisms of BCR–ABL in the pathogenesis of chronic myelogenous leukaemia - Full text - MIT Libraries
R Ren - Nature Reviews Cancer, 2005 - nature.com
... AML1 (also known as RUNX1 and CBFα2),part of which is fused to EVI1 in AME ... cells
isolated from patients with blast-phase CML include mutations in TP53, RB, and ...
Cited by 2 - Web Search - nature.com - ncbi.nlm.nih.gov

Expression Profiling of Genes and Proteins in HaCaT Keratinocytes: Proliferating Versus … - Full text - MIT Libraries
G Lemaıt, J Lamartine, A Pitaval, P Vaigot, J … - Journal of Cellular Biochemistry, 2004 - doi.wiley.com
Page 1. Journal of Cellular Biochemistry 93:1048–1062 (2004) Expression Profiling
of Genes and Proteins in HaCaT Keratinocytes: Proliferating ...
Cited by 3 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Epigenetic and Chromatin Modifiers As Targeted Therapy of Hematologic Malignancies - Full text - MIT Libraries
KN Bhalla - J Clin Oncol, 2005 - jco.org
... 136-138 For example, in AML, the dimerization domains in the partners of the core
binding factor (CBF) AML1 (also known as RUNX1 or CBFA2), including TEL, ETO ...
Cited by 2 - Web Search - dx.doi.org - jco.org - ncbi.nlm.nih.gov

G ENETIC P ROFILE OF A CUTE M YELOID L EUKEMIA - Full text - MIT Libraries
C Mecucci, R Rosati, R La Starza - Reviews in Clinical & Experimental Hematology, 2002 - blackwell-synergy.com
... Most cases also show the typical rearrangements of secondary leukemias, such as
complete loss or interstitial deletion of chromosome 5q, and mutations of TP53. ...
Cited by 4 - Web Search - ingentaconnect.com - ncbi.nlm.nih.gov