Combined vascular endothelial growth factor and TP53 status predicts poor response to tamoxifen … - Full text - MIT Libraries
EM Berns, JG Klijn, MP Look, N Grebenchtchikov, R … - Clin Cancer Res, 2003 - clincancerres.aacrjournals.org
... Interestingly, Pal et al. (11) recently showed a direct effect of TP53 on VEGF,
in that TP53 makes a complex with Sp1 and thereby inhibits Sp1-mediated VEGF ...
Cited by 6 - Web Search - clincancerres.aacrjournals.org - ncbi.nlm.nih.gov

Activation of nuclear factor kappaB in radioresistance of TP53-inactive human keratinocytes - Full text - MIT Libraries
X Chen, B Shen, L Xia, A Khaletzkiy, D Chu, JY … - Cancer Res, 2002 - cancerres.aacrjournals.org
... Tumor Biology. Activation of Nuclear Factor B in Radioresistance of TP53-inactive
Human Keratinocytes 1. ... 3. NF- B, but not TP53, was activated in HK18-IR cells. ...
Cited by 20 - Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Vascular endothelial growth factor expression is up-regulated by EWS-ETS oncoproteins and Sp1 and … - Full text - MIT Libraries
B Fuchs, CY Inwards, R Janknecht - Clin Cancer Res, 2004 - intl-clincancerres.aacrjournals.org
... VP The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress ...
Nobori T., Kaneko Y. Analysis of the p16INK4, p14ARF, p15, TP53, and MDM2 ...
Cited by 7 - Web Search - intl-clincancerres.aacrjournals.org - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Activation of the human PAX6 gene through the exon 1 enhancer by transcription factors SEF and Sp1 - Full text - MIT Libraries
JB Zheng, YH Zhou, T Maity, WS Liao, GF Saunders - Nucleic Acids Res, 2001 - nar.oupjournals.org
... AC and Van Meir,EG (???? Frequent co-alterations of TP53, p16/CDKN2A ... KV and
Chang,KS (1998) The promyelocytic leukemia protein interacts with Sp1 and inhibits ...
Cited by 4 - Web Search - pubmedcentral.nih.gov - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Oligo GEArray® Human Breast Cancer Biomarkers Microarray
PP Markers - search.cosmobio.co.jp
... IGFBP3, PTEN Transcription factors and regulators: AR, BRCA1, BRCA2, CTNNB1, EGR3,
ESR1, ESR2, FOS, JUN, MYC, NR4A1, PCNA, PGR, RB1, SP1, TNF, TP53, TSG101. ...
View as HTML - Web Search

Identification of Novel Candidate Oncogenes and Tumor Suppressors in Malignant Pleural Mesothelioma … - Full text - MIT Libraries
GJ Gordon, GN Rockwell, RV Jensen, JG Rheinwald, … - American Journal of Pathology, 2005 - ajp.amjpathol.org
Page 1. Tumorigenesis and Neoplastic Progression Identification of Novel Candidate
Oncogenes and Tumor Suppressors in Malignant Pleural ...
Web Search - ajp.amjpathol.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 5 versions »

A comparative analysis of relative occurrence of transcription factor binding sites in vertebrate … - Full text - MIT Libraries
M Stepanova, T Tiazhelova, M Skoblov, A Baranova - Bioinformatics, 2005 - bioinformatics.oxfordjournals.org
... Five TFs, namely TP53, NRSF, EVI1, SP1 and GC box element were characterized by
real occurrences prevailing on F-values in all five vertebrate genomes analyzed ...
Web Search - bioinformatics.oupjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 7 versions »

Early Induction of CDKN 1 A(P 21) and GADD 45 mRNA by a Low Dose of Ionizing Radiation is due to … - Full text - MIT Libraries
K Daino, S Ichimura, M Nenoi - Radiation Research, 2002 - bioone.org
... 15) , which has recently been identified as a regulator of TP53 target genes ... Regulation
of the catalase gene promoter by Sp1, CCAAT-recognizing factors, and a ...
Cited by 9 - Web Search - apt.allenpress.com - ncbi.nlm.nih.gov - csa.com - all 6 versions »

Modulation of cell cycle‐related protein expression by sodium butyrate in human non‐small cell … - Full text - MIT Libraries
C Pellizzaro, D Coradini, A Daniotti, G Abolafio, … - International Journal of Cancer, 2001 - doi.wiley.com
... NCI- H460 cells exhibited a wild-type TP53 gene ... 22 Their results demonstrated that
the WAF1/CIP1 gene can be regulated through specific Sp1 sites present on the ...
Cited by 19 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Pancreatic cancer research: challenges, opportunities, and recent developments.
ME Fernandez-Zapico, JA Kaczynski, R Urrutia - Current Opinion in Gastroenterology, 2002 - co-gastroenterology.com
... this approach resulted in the discovery of K-ras, TP16, TP53, and DPC4 as a ... our efforts
on the identification and functional characterization of Sp1-like zinc ...
Web Search - co-gastroenterology.com

GEArray S Series Human Immunology Signaling Pathways Gene Array: AR-SAHS-605
FG Grouping, A Molecules, I ICAM, CS Molecules, C … - eurogentec.com
... MAPKAPK2, MAPKAPK3, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MHC2TA, MKNK1, MLLT7, MYC,
MYF5, NFKB2, NFKBIB, NFKBIE, NR4A2, PCNA, RAF1, RELA, RPS6KA5, SP1, SP3, TP53. ...
View as HTML - Web Search - eurogentec.be

Exploring Toll-Like Receptor Regulation of Innate Immunity with the Tools of Systems Biology
KD Smith, V Thorsson - Current Genomics, 2004 - ingentaconnect.com
... NF-κB binding sites on human chromosome 22 in HeLa cells [23], as well chromosomes
21 and 22 binding sites for cMyc (MYC), Sp1 (SP1) and p53 (TP53) in Jurkat ...
Web Search

Methylation of the p73 gene in gliomas - Full text - MIT Libraries
T Watanabe, H Huang, M Nakamura, J Wischhusen, M … - Acta Neuropathol, 2002 - springerlink.com
... homologous to TP53 in three re- gions, corresponding to the TP53 transcriptional
domain ... in CpG dinucleotides and contains putative binding sites for Sp1, AP-2 ...
Cited by 13 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Modulation of retrovirally driven therapeutic genes by mutant TP 53 in anaplastic thyroid carcinoma
L Barzon, E Gnatta, I Castagliuolo, M Trevisan, F … - Cancer Gene Therapy, 2005 - nature.com
... TP53 in anaplastic thyroid carcinoma ... In conclusion, TP53 status in the
tumor cell can influence expression of therapeutic genes. ...
Web Search - nature.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

ATM-dependent and-independent gene expression changes in response to oxidative stress, gamma … - Full text - MIT Libraries
AN Heinloth, RE Shackelford, CL Innes, L Bennett, … - Radiat Res, 2003 - bioone.org
... While none of these genes are regulated by TP53 or E2F, three genes have binding
sites for SP1. These three genes are EPOR (35) , CXCR4 (36) and MCL1 (37) . ...
Cited by 8 - Web Search - apt.allenpress.com - bioone.org - ncbi.nlm.nih.gov - all 5 versions »

Associations between common polymorphisms in TP 53 and p 21 WAF 1/Cip 1 and phenotypic features of … - Full text - MIT Libraries
BL Powell, IL van Staveren, P Roosken, F Grieu, EM … - Carcinogenesis, 2002 - carcin.oupjournals.org
... WD (1996) Polymorphisms in p21(CIP1/WAF1) are not correlated with TP53 status in ...
of the p21(WAF1) cyclin-dependent kinase inhibitor gene through Sp1 and CBP ...
Cited by 11 - Web Search - carcin.oxfordjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov - all 6 versions »

Radiosensitization by inhibition of IkappaB-alpha phosphorylation in human glioma cells - Full text - MIT Libraries
GR Ding, N Honda, T Nakahara, F Tian, M Yoshida, H … - Radiat Res, 2003 - bioone.org
... effect of NFKB on radiosensitivity and PLD repair may be the TP53 protein. ... Coordinate
modulation of Sp1, NF-κB, and p53 in confluent human malignant melanoma ...
Cited by 5 - Web Search - apt.allenpress.com - bioone.org - ncbi.nlm.nih.gov - all 5 versions »

Identification and classification of p53-regulated genes - Full text - MIT Libraries
J Yu, L Zhang, PM Hwang, C Rago, KW Kinzler, B … - Cancer Res, 2004 - dx.doi.org
... FA Wright, R. Davuluri, JC Lockman, A. de la Chapelle, and NS Pellegata Gene expression
profiling of isogenic cells with different TP53 gene dosage reveals ...
Cited by 199 - Web Search - pnas.org - pubmedcentral.nih.gov - milkpa.idv.tw - all 8 versions »

Regulation of TNFRSF6 (Fas) expression in ataxia telangiectasia cells by ionizing radiation - Full text - MIT Libraries
J Albanese, N Dainiak - Radiat. Res, 2000 - bioone.org
... of TNFRSF6 in AT cells may proceed through TP53-independent mechanisms. Numerous
putative binding sites for transcription factors, including SP1, NFKB, AP1 ...
Cited by 7 - Web Search - bioone.org - apt.allenpress.com - ncbi.nlm.nih.gov

Toward a more complete recognition of immunoreactive antigens in squamous cell lung carcinoma - Full text - MIT Libraries
I Diesinger, C Bauer, N Brass, HJ Schaefers, N … - International Journal of Cancer, 2002 - doi.wiley.com
... antigens most frequently identified were the lymphoid blast crisis oncogene (LBC),
an unknown hypothetical protein and the p53-binding protein (TP53 BP), which ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

FHIT and TSG101 in thyroid tumours: aberrant transcripts reflect rare abnormal RNA processing events … - Full text - MIT Libraries
B McIver, SKG Grebe, L Wang, ID Hay, A Yokomizo, W … - Clinical Endocrinology, 2000 - dx.doi.org
... TP53 transcript amplification was performed by nested PCR, as described above, using
primers ... as in the PCR reactions and with sequencing primers SP1, SP2, SP3 ...
Cited by 4 - Web Search - blackwell-synergy.com - ingentaconnect.com - ncbi.nlm.nih.gov

The radioresponse of the central nervous system: a dynamic process - Full text - MIT Libraries
PJ Tofilon, JR Fike - Radiat Res, 2000 - bioone.org
... irradiation of the adult rat cerebral cortex has also been found to increase the
DNA-binding activity of the transcription factors Tp53, Ap1 and Sp1 (Raju et al ...
Cited by 36 - Web Search - bioone.org - apt.allenpress.com - ncbi.nlm.nih.gov

SINE retroposons can be used in vivo as nucleation centers for de novo methylation - Full text - MIT Libraries
P Arnaud, C Goubely, T Pelissier, JM Deragon - Mol Cell Biol, 2000 - mcb.asm.org
... the mouse aprt (adenine phosphoribosyl transferase) promoter after disruption of
Sp1 elements, which ... 13) and in the methylation of an exon of the TP53 gene (28 ...
Cited by 25 - Web Search - pubmedcentral.nih.gov - mcb.asm.org - ncbi.nlm.nih.gov

2 Genetic polymorphisms in the MMP-2 and MMP-9 genes and breast cancer 3 phenotype - Full text - MIT Libraries
F Grieu, WQ Li, B Iacopetta - Breast Cancer Research and Treatment, 2004 - kluweronline.com
... in the promoter region 12 of MMP-2 ()1306 CfiT) abolishes Sp1 binding and is ...
non-ductal type histology, positive ER 22 status and the absence of TP53 mutation. ...
Web Search - springerlink.com - ncbi.nlm.nih.gov

Interaktion genetischer und epigenetischer Veraenderungen in Karzinomen des Harntraktes
AR Florl - deposit.ddb.de
... Im Gegensatz dazu binden einige Faktoren methylierungsunabhängig. Die Faktoren
Sp1, CTF und YY1 sind beispielsweise ... von TP53. Ein ...
Web Search

Characterization of the human ribonucleotide reductase M2 subunit gene; genomic structure and …
B Zhou, Y Yen, F Alert - Cytogenet. Cell Genet, 2001 - content.karger.com
... GC boxes are typical Sp1 transcription factor binding sites found in many genes
and ... TP53 (alias P53) is a known tumor suppressor gene that has been postulated ...
Cited by 10 - Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 7 versions » - Get it from MIT Libraries

GEArray Q series Human p53 Signaling Pathway Gene Array: AR-SAHS-027
FG Grouping - eurogentec.com
... Functional Gene Grouping p53 family: TP53, TP63, TP73 ... HSPA4 (Hsp70), LRDD, MAP4,
NDRG (RTP), PIG8 (E124), PMP22, RELA, REPRIMO, SFN (14-3-3), SP1, STAT5A, TBP ...
View as HTML - Web Search - eurogentec.be

GEArray Q series Human p53 Signaling Pathway Gene Array Cat. No.* Kit Size HS-027-2/HS-027N-2 2 …
FG Grouping - tebu-bio.com
... Functional Gene Grouping p53 family: TP53, TP63, TP73 ... HSPA4 (Hsp70), LRDD, MAP4,
NDRG (RTP), PIG8 (E124), PMP22, RELA, REPRIMO, SFN (14-3-3), SP1, STAT5A, TBP ...
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GEArray Q series Human p53 Signaling Pathway Gene Array
FG Grouping - superarray.com
... p53 family: TP53, TP63, TP73 ... GTSE1 (B99), HIF1A, HSPA4 (Hsp70), LRDD, MAP4, NDRG
(RTP), PIG8 (E124), PMP22, RELA, REPRIMO, SFN (14-3-3), SP1, STAT5A, TBP, THRA ...
View as HTML - Web Search - superarray.com - cosmobio.co.jp - cosmobio.co.jp - all 5 versions »

Experimental and clinicopathologic study on the relationship between transcription factor Egr-1 and … - Full text - MIT Libraries
MY Wu, MH Chen, YR Liang, GZ Meng, HX Yang, CX … - World J Gastroenterol, 2001 - wjgnet.com
... in oncogene and tumor suppressor gene and abolishes the function of SP1, leading
to ... LOH at the sites of the DCC, APC, and TP53 tumor suppressor genes occurs in ...
Cited by 11 - View as HTML - Web Search - wjgnet.com - wjgnet.com - ncbi.nlm.nih.gov - all 5 versions »

Identification of a leader exon and a core promoter for the rat tuberous sclerosis 2( Tsc 2) gene … - Full text - MIT Libraries
T Kobayashi, S Urakami, JP Cheadle, R Aspinwall, P … - Mammalian Genome, 1997 - springerlink.com
... core sequence found in rat was not conserved; however, two other Sp1 sites were ...
regulation of Tsc2 and TSC2 may occur as suggested for murine TP53 or human ...
Cited by 18 - Web Search - ncbi.nlm.nih.gov

The p 53 story: layers of complexity - Full text - MIT Libraries
AW Braithwaite, JA Royds, P Jackson - Carcinogenesis, 2005 - carcin.oxfordjournals.org
... clearly contributes to malignant development, the role of natural TP53 variants
(polymorphisms ... analysis predicts that having G makes a better Sp1 binding motif ...
Web Search - carcin.oxfordjournals.org - ingentaconnect.com - ncbi.nlm.nih.gov

Metabolizing Enzymes in Human Breast Cancer
TJM Sci - journals.tubitak.gov.tr
... can be explained by rare, highly penetrant genes such as BRCA1, BRCA2 and TP53. ... CYP17
contains a single-base polymorphism that creates a SP1-type (CCACC box ...
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Unique Features of the Mode of Action of ET-743 - Full text - MIT Libraries
M D'Incalci, E Erba, G Damia, E Galliera, L … - The Oncologist, 2002 - theoncologist.alphamedpress.org
... TBP), and NF-Y. No inhibition of DNA binding was found for Sp1, Maf, MYB ... or cells
from the A2780/CX3 subline transfected with a dominant-negative mutant TP53 [26 ...
Cited by 12 - Web Search - dx.doi.org - theoncologist.alphamedpress.org - ncbi.nlm.nih.gov

Small molecule antagonists of the MDM2 oncoprotein as anticancer agents
JK Buolamwini, J Addo, S Kamath, S Patil, D Mason, … - Curr Cancer Drug Targets, 2005 - ingentaconnect.com
... in knockout mice causes death at the embryonic stage unless the TP53 gene (the ... results
in a higher affinity for the transcriptional activator Sp1, leading to ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

ERTargetDB: an integral information resource of transcription regulation of ER target genes
VX Jin, H Sun, TT Pohar, S Liyanarachchi, SK … - journals.endocrinology.org
... indirect tethering, where ERs interact with other transcription factors such as
AP-1, Sp1 ... 2005), Sp1 (Schultz et al. 2005) or NF-Kappaβ (Qin et al. 2002). ...
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FMGA: finding motifs by genetic algorithm
FFM Liu, JJP Tsai, RM Chen, SN Chen, SH Shih - Bioinformatics and Bioengineering, 2004. BIBE 2004. …, 2004 - ieeexplore.ieee.org
... Besides TBP and Sp1 factors, there are also other factors to aid the DNA ... E-cadherin
(CDH1), E2F1, FABP3, FHIT, M6PR, IGF2R, NF2, NME1, PTEN, TGFB1, TP53 We set ...
Cited by 1 - Web Search - doi.ieeecomputersociety.org - ieeexplore.ieee.org

The Function of BRCA 1 in DNA Damage Response
JS LEE, K COLLINS, A BROWN, CH LEE, JH CHUNG - Cold Spring Harbor Symposia on Quantitative Biology, 2000 - dx.doi.org
... One explanation may be that the high frequency of TP53 mutation or ... growth fac-
tor-I receptor promoter activity: Potential interaction between BRCA1 and Sp1. ...
Cited by 1 - Web Search - cshl-symposium.org - cshl-symposium.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Changes in p14 (ARF) do not play a primary role in human chondrosarcoma tissues - Full text - MIT Libraries
J Asp, C Brantsing, MS Benassi, S Inerot, L … - Int J Cancer, 2001 - doi.wiley.com
... Analysis of the p16INK4, p14 ARF , p15, TP53, and MDM2 genes and their prognostic ...
Sp1 sites in the mouse aprt gene promoter are required to prevent methylation ...
Cited by 3 - Web Search - doi.wiley.com - ncbi.nlm.nih.gov

Aberrant methylation of TMS1 in small cell, non small cell lung cancer and breast cancer - Full text - MIT Libraries
A Virmani, A Rathi, K Sugio, UG Sathyanarayana, S … - Int J Cancer, 2003 - doi.wiley.com
... to apoptosis, such as mutational inactivation of proapoptotic genes TP53 and BAX
or ... transcription factor binding sites, namely E2F AP-2, WT1, SP1, NRSE, SP1 ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Impaired regulation of tumor suppressor p53 caused by mutations in the xeroderma pigmentosum DDB2 … - Full text - MIT Libraries
T Itoh, C O'Shea, S Linn - Mol. Cell. Biol, 2003 - pubmedcentral.nih.gov
... from each of five XP-E strains of exons 5 through 8 of TP53, which are known ... regulatory
elements in intron 4 including CREB, CRE-BP1/c-Jun, p300, Sp1, E2F, Ap1 ...
Cited by 7 - Web Search - dx.doi.org - mcb.asm.org - ncbi.nlm.nih.gov - all 5 versions »

p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased … - Full text - MIT Libraries
S Rocha, AM Martin, DW Meek, ND Perkins - Mol. Cell. Biol, 2003 - mcb.asm.org
... and also consistent with the effects seen in H1299 w/tp53 cells, a ... MDM2 induces NF-
B/p65 expression transcriptionally through Sp1-binding sites: a novel, p53 ...
Cited by 21 - Web Search - pubmedcentral.nih.gov - dx.doi.org - ncbi.nlm.nih.gov - all 6 versions »

BMC Cancer - Full text - MIT Libraries
M Raponi, RT Belly, JE Karp, JE Lancet, D Atkins, … - BMC Cancer, 2004 - biomedcentral.com
Page 1. ...
View as HTML - Web Search - biomedcentral.com - bmc.ub.uni-potsdam.de

p53 and brain tumors: from gene mutations to gene therapy - Full text - MIT Libraries
G Fulci, N Ishii, EG Van Meir - Brain Pathol, 1998 - brainpathology.com
... Transfer of TP53 can induce apoptosis in different cell types, including human glioma ...
Cell, 90:595 p300 Avantaggiati ML., 1997, Cell, 89:1175 Sp1 Borellini F ...
Cited by 37 - Web Search - brainpath.medsch.ucla.edu - brainpath.medsch.ucla.edu - ncbi.nlm.nih.gov

Cytosine methylation and mammalian development - Full text - MIT Libraries
CP Walsh, TH Bestor - Genes Dev, 1999 - genesdev.org
... Magewu and Jones (1994) found that an exon of the TP53 gene that is ... The binding and
activity of Sp1 and some other transcription factors is insensitive to ...
Cited by 141 - Web Search - genesdev.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - all 7 versions »

Genetic predictors for drug resistance in soft tissue sarcoma: a review of publications in 2004.
J Fayette, JY Blay - Current Opinion in Oncology, 2005 - co-oncology.com
... of stresses [7••]. Its dysfunction may be caused by mutations of the TP53 gene as ...
A recent study showed that wild-type p53 binds to a Sp1 binding site (-244 ...
Web Search - co-oncology.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Genetic polymorphism in myeloperoxidase but not GSTM 1 is associated with risk of lung squamous cell … - Full text - MIT Libraries
W Lu, D Xing, J Qi, W Tan, X Miao, D Lin - International Journal of Cancer, 2002 - doi.wiley.com
... in the promoter region (-463G to A) and leads to the loss of SP1 transcription binding ...
at guanine residues in codons 157, 248 and 273 of the TP53 gene, which ...
Cited by 4 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

A comprehensive review of genetic association studies
JN Hirschhorn, K Lohmueller, E Byrne, K Hirschhorn - Genet Med, 2002 - psych.umn.edu
... PGR (64) SHBG (65) SOD2 (66) TP53 (67) VDR (68) Cervical cancer GSTT1 (69) MTHFR
(70) TP53 (71) ... MYCL1 (104) NAT1 (48) NAT2 (102, 105) TP53 (106) ...
Cited by 184 - View as HTML - Web Search - geneticsinmedicine.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Untersuchungen zum Einfluss des Strahlenprotektors Bowman-Birk-Proteinase-Inhibitor auf die …
A Radioonkologie, A Direktor, PDM Bamberg, S fuer … - w210.ub.uni-tuebingen.de
... 1993a). Neben dem TP53 werden noch eine Vielzahl anderer Substrate wie SP1, Fos,
Jun und Myc aktiviert, die ihrerseits Einfluss auf die Aktivierung und ...
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Loss of RUNX3 Expression Significantly Affects the Clinical Outcome of Gastric Cancer Patients and … - Full text - MIT Libraries
D Wei, W Gong, SC Oh, Q Li, WD Kim, L Wang, X Le, … - Cancer Research, 2005 - cancerres.aacrjournals.org
... the l3 loop and LSH motif DNA-binding domains of TP53 predict poor ... Transcription
factor Sp1 expression is a significant predictor of survival in human gastric ...
Web Search - cancerres.aacrjournals.org - ncbi.nlm.nih.gov