1: Pathol Biol (Paris). 1999 Apr;47(4):358-63. 

[Transcription factors and angiogenesis]

[Article in French]

Soncin F, Fafeur V, Vandenbunder B.

EP 560 CNRS, Institut Pasteur de Lille, Institut de Biologie de Lille, France.

Various strategies led to the identification of transcription factors that take
part to the control of different steps during the formation of new blood
vessels: the description of the expression pattern of genes encoding these
factors during embryonic development for ETS-1, ERG and FLI, SCL/TAL, GATA1 and
2, the description of the phenotype of embryos obtained after gene inactivation
by homologous recombination for ARNT or LKLF, and the study of transcriptional
regulation in cultured endothelial cells for EGR1 or HOX-D3. Altogether, these
results showed that there is no transcription factor specific for endothelial
cells or for one step in the formation of blood vessels. Rather, factors
controlling gene expression induced by hypoxia, shear-stress or growth factors
take part in the morphogenesis of the vascular tree. The study of these factors
may allow to identify potential therapeutic targets for treatments aimed at
inhibiting or stimulating the development of new blood vessels.

Publication Types:
    Review
    Review, Tutorial

PMID: 10372405 [PubMed - indexed for MEDLINE]


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