1: Oncol Rep. 2005 Jul;14(1):291-4. 

Comparative genomics on Fgf11 orthologs.

Katoh Y, Katoh M.

M&M Medical BioInformatics, Hongo 113-0033, Japan.

Human FGF19 is the ortholog of rodent Fgf15, and 22 FGF family genes exist
within the human genome as well as within the rodent genome. Mouse Fgf11 refSeq
NM_010198.1 and rat Fgf11 RefSeq NM_130816.1 correspond only to the coding
region. Here, complete coding sequences of mouse, rat and dog Fgf11 orthologs
were determined by using bioinformatics. Mouse Fgf11, rat Fgf11 and dog Fgf11
genes, consisting of five exons, were located within AL603707.5, AC098923.8 and
AC126237.5 genome sequences, respectively. Human FGF11 showed 97.8%, 96.9%,
96.9% and 68.9% total-amino-acid identity with dog, mouse, rat and zebrafish
Fgf11 orthologs, respectively. Rat Fgf11 showed Val205Met amino-acid
substitution compared with rat Fgf11 RefSeq NP_570829.1. Met 205 of rat Fgf11
determined in this study was conserved among vertebrate Fgf11 orthologs.
N-terminal signal peptide was not identified within vertebrate Fgf11 orthologs.
Two Asn-linked glycosylation sites were identified within zebrafish fgf11, but
not within mammalian Fgf11 orthologs. The 5'-flanking region, exonic regions,
and intronic regions except intron 3 were well conserved between human FGF11 and
mouse Fgf11 genes. Match program revealed that EVI1, ELK1, AP1 and E47-binding
sites were conserved between human FGF11 and mouse Fgf11 promoter regions. Human
FGF11 mRNA was expressed in embryonic stem (ES) cells, neuroblastoma,
retinoblastoma, and brain tumors. This is the first report on the dog Fgf11 gene
as well as on comparative genomics analyses of Fgf11 orthologs.

PMID: 15944803 [PubMed - indexed for MEDLINE]


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