1: J Hum Genet. 2003;48(12):654-8. Epub 2003 Nov 21. 

Allele frequencies of single nucleotide polymorphisms (SNPs) in 40 candidate
genes for gene-environment studies on cancer: data from population-based
Japanese random samples.

Yoshimura K, Hanaoka T, Ohnami S, Ohnami S, Kohno T, Liu Y, Yoshida T, Sakamoto
H, Tsugane S.

Cancer Information and Epidemiology Division, National Cancer Center Research
Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. kyoshimu@ncc.go.jp

Knowledge of genetic polymorphisms in gene-environment studies may contribute to
more accurate identification of avoidable risks and to developing tailor-made
preventative measures. The aim of this study was to describe the allele
frequencies of single nucleotide polymorphisms (SNPs) of select genes, which may
be included in future gene-environment studies on cancer in Japan. SNP typing
was performed on middle-aged Japanese men randomly selected from the general
population in five areas of Japan. We genotyped and calculated allele
frequencies of 153 SNPs located on 40 genes: CYP1A1, CYP1B1, CYP2C9, CYP2C19,
CYP2E1, CYP17A1, CYP19A1, AHR, ESR1, ESR2, ERRRG, PGR, EPHX1, EPHX2, HSD17B2,
HSD17B3, GSTM2, GSTM3, GSTT2, GSTP1, NAT1, NAT2, COMT, ADH1A, ADH1B, ADH1C,
ALDH2, NOS2A, NOS3, IL1A, IL1B, OGG1, NUDT1 [MTH1], DRD2, DRD3, DRD4, SLC6A4,
NR3C1 [GCCR], MTHFR, and NQO1. In the present study, the Japanese allele
frequencies were verified by using nationwide population samples.

PMID: 14634838 [PubMed - indexed for MEDLINE]


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