1: Neurosci Lett. 2005 Jul 1-8;382(1-2):175-8. Epub 2005 Apr 2. 

The neuronal POU transcription factor Brn-2 interacts with Jab1, a gene involved
in the onset of neurodegenerative diseases.

Huang YT, Iwamoto K, Kurosaki T, Nasu M, Ueda S.

Department of Biological Science, Graduate School of Sciences, The University of
Tokyo, Tokyo 113-0033, Japan.

Brain-2 (Brn-2), a Class III POU transcription factor, plays an important role
in the development of the neocortex and the establishment of neural cell
lineage. Here we performed a yeast two-hybrid screening to identify the Brn-2
binding proteins. We obtained Jun-activation-domain-binding protein 1 (Jab1) as
a new Brn-2 binding protein. Direct interaction between Brn-2 and Jab1 was
confirmed by using a surface plasmon resonance biosensor. Considering the
involvement of Jab1 in the onset of the neurodegenerative disorders such as
Parkinson's disease and Alzheimer's disease, the interaction between Brn-2 and
Jab1 may provide some insights into the understanding of neuronal development
and neurodegenerative diseases.

PMID: 15911144 [PubMed - indexed for MEDLINE]


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