1: Leuk Res. 2005 Oct 7; [Epub ahead of print] 

Histologic and molecular characterizations of megakaryocytic leukemia in mice.

Hao X, Shin MS, Zhou JX, Lee CH, Qi CF, Naghashfar Z, Hartley JW, Fredrickson
TN, Ward JM, Morse HC 3rd.

Laboratory of Immunopathology, National Institute of Allergy and Infectious
Diseases, National Institute of Health, Rockville, MD 20852, USA.

Six cases of megakaryocytic leukemia (MKL) were identified and analyzed for
morphology and molecular features. MKL were composed of megakaryocyte lineage
cells ranging from immature to quite mature cells. VWF, GATA1 and RUNX1 were
strongly expressed in megakaryocytes in both normal spleen and MKL as analyzed
by immunohistochemistry (IHC). Altered expression of Meis1, Pbx1 and Psen2 and
Lef1 in MKL detected with oligonucleotide microarrays was confirmed by qPCR and
IHC. This is the first report of spontaneous MKL in mice, defining VWF as a
biomarker for diagnosis and suggesting possible involvement of a series of genes
in disease pathogenesis.

PMID: 16219351 [PubMed - as supplied by publisher]


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