1: Clin Exp Immunol. 1998 Feb;111(2):339-44. 

Expression of Pax5 gene in human haematopoietic cells and tissues: comparison
with immunodeficient donors.

Kaneko H, Ariyasu T, Inoue R, Fukao T, Kasahara K, Teramoto T, Matsui E,
Hayakawa S, Kondo N.

Department of Paediatrics, Gifu University School of Medicine, Japan.

In mice, Pax5 gene is indispensable for B cell development. Pax5-deficient mice
fail to produce mature B cells owing to complete arrest of B cell development at
a precursor stage. However, the lineage and stage of human Pax5 gene expression
have remained elusive. In this investigation expression of the human Pax5 gene
was studied. Pax5 gene expression was detected in B cell lines but not in
myeloma cell lines. CD19 expression was correlated with Pax5 gene expression.
Adult spleen and bone marrow and fetal spleen and liver showed strong Pax5 gene
expression, as did the corresponding mouse tissues, as reported previously. In
common variable immunodeficiency (CVID) peripheral blood lymphocytes (PBL) with
a decreased number of B cells, no Pax5 gene expression was detected. Some CVID
PBL stimulated with IL-2, IL-10 and anti-CD40 monoclonal antibody, expressed the
Pax5 gene. Defect of Pax5 gene expression in CVID may be caused by regulatory T
cell disorder.

PMID: 9486401 [PubMed - indexed for MEDLINE]


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