1: Mol Genet Metab. 2000 Feb;69(2):85-100. 

Developmental patterning genes and their conserved functions: from model
organisms to humans.

Veraksa A, Del Campo M, McGinnis W.

Department of Biology, University of California, San Diego, La Jolla, California
92093, USA.

Molecular and genetic evidence accumulated during the past 20 years in the field
of developmental biology indicates that different animals possess many common
genetic systems for embryonic patterning. In this review we describe the
conserved functions of such developmental patterning genes and their relevance
for human pathological conditions. Special attention is given to the Hox genetic
system, involved in establishing cell identities along the anterior-posterior
axis of all higher metazoans. We also describe other conserved genetic systems,
such as the involvement of Pax6 genes in eye development and the role of
Nkx2.5-type proteins in heart development. Finally, we outline some fascinating
problems at the forefront of the studies of developmental patterning genes and
show how knowledge obtained from model genetic organisms such as Drosophila
helps to explain normal human morphogenesis and the genetic basis of some birth
defects. Copyright 2000 Academic Press.

Publication Types:
    Review

PMID: 10720435 [PubMed - indexed for MEDLINE]


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