1: Annu Rev Immunol. 1999;17:149-87. 

Transcriptional regulation of T lymphocyte development and function.

Kuo CT, Leiden JM.

Department of Medicine, University of Chicago, Illinois 60637, USA.

The development and function of T lymphocytes are regulated tightly by signal
transduction pathways that include specific cell-surface receptors,
intracellular signaling molecules, and nuclear transcription factors. Since
1988, several families of functionally important T cell transcription factors
have been identified. These include the Ikaros, LKLF, and GATA3 zinc-finger
proteins; the Ets, CREB/ATF, and NF-kappa B/Rel/NFAT transcription factors; the
Stat proteins; and HMG box transcription factors such as LEF1, TCF1, and Sox4.
In this review, we summarize our current understanding of the transcriptional
regulation of T cell development and function with particular emphasis on the
results of recent gene targeting and transgenic experiments. In addition to
increasing our understanding of the molecular pathways that regulate T cell
development and function, these results have suggested novel targets for genetic
and pharmacological manipulation of T cell immunity.

Publication Types:
    Review

PMID: 10358756 [PubMed - indexed for MEDLINE]


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