1: Mol Biol Cell. 2003 Nov;14(11):4376-86. Epub 2003 Sep 5. 

Gene expression patterns in ovarian carcinomas.

Schaner ME, Ross DT, Ciaravino G, Sorlie T, Troyanskaya O, Diehn M, Wang YC,
Duran GE, Sikic TL, Caldeira S, Skomedal H, Tu IP, Hernandez-Boussard T, Johnson
SW, O'Dwyer PJ, Fero MJ, Kristensen GB, Borresen-Dale AL, Hastie T, Tibshirani
R, van de Rijn M, Teng NN, Longacre TA, Botstein D, Brown PO, Sikic BI.

Stanford University School of Medicine, Stanford, California 94305-5151, USA.

We used DNA microarrays to characterize the global gene expression patterns in
surface epithelial cancers of the ovary. We identified groups of genes that
distinguished the clear cell subtype from other ovarian carcinomas, grade I and
II from grade III serous papillary carcinomas, and ovarian from breast
carcinomas. Six clear cell carcinomas were distinguished from 36 other ovarian
carcinomas (predominantly serous papillary) based on their gene expression
patterns. The differences may yield insights into the worse prognosis and
therapeutic resistance associated with clear cell carcinomas. A comparison of
the gene expression patterns in the ovarian cancers to published data of gene
expression in breast cancers revealed a large number of differentially expressed
genes. We identified a group of 62 genes that correctly classified all 125
breast and ovarian cancer specimens. Among the best discriminators more highly
expressed in the ovarian carcinomas were PAX8 (paired box gene 8), mesothelin,
and ephrin-B1 (EFNB1). Although estrogen receptor was expressed in both the
ovarian and breast cancers, genes that are coregulated with the estrogen
receptor in breast cancers, including GATA-3, LIV-1, and X-box binding protein
1, did not show a similar pattern of coexpression in the ovarian cancers.

PMID: 12960427 [PubMed - indexed for MEDLINE]


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