1: Biochem Biophys Res Commun. 1994 Feb 28;199(1):255-63. 

Structure of the mouse peroxisome proliferator activated receptor alpha gene.

Gearing KL, Crickmore A, Gustafsson JA.

Centre for Biotechnology, Karolinska Institute, Novum, Huddinge University
Hospital, Sweden.

We have isolated and characterised genomic clones spanning the mouse peroxisome
proliferator activated receptor alpha gene (PPAR alpha). The gene contains eight
exons spanning at least 30 kilobases. The DNA binding domain of PPARa consists
of two exons, each encoding one of the zinc fingers. Three exons encode the
ligand binding domain and 3' untranslated regions of PPAR alpha. There are two
5' untranslated exons and one exon encoding the N-terminal domain. The 5'
flanking region is GC rich and contains several putative SP1 binding sites. The
structure of the PPAR alpha gene is unique but shares similar features with
related members of the nuclear hormone receptor family.

PMID: 8123021 [PubMed - indexed for MEDLINE]


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