1: Int J Dev Biol. 1994 Dec;38(4):591-604. 

Control of skeletal muscle-specific transcription: involvement of paired
homeodomain and MADS domain transcription factors.

Duprey P, Lesens C.

Laboratoire de Biologie Moleculaire de la Differenciation, UFR de Biochimie,
Universite Paris VII Denis Diderot, France.

In the last few years, many aspects of skeletal muscle-specific gene regulation
have been explained by the activity of the helix-loop helix (HLH) myogenic
regulatory factors of the MyoD family, which are sequentially expressed during
skeletal muscle formation. However, evidence is accumulating that muscle
specific transcription requires functional interactions of these muscle-specific
HLH factors with other regulatory proteins whose expression is not only
restricted to skeletal muscle. These regulators include the SRF and MEF2 MADS
domain and the MHox paired homeodomain transcription factors. Together with the
aforementioned HLH factors, they build an increasingly complex network of
regulatory factors. Two members of the Pax multigenic family of developmental
control transcription factors, Pax-3 and 7, have been shown to be expressed not
only in nervous tissue but also in skeletal muscle precursor cells. Their
possible involvement in the control of muscle-specific transcription is
discussed in light of known molecular properties of Pax gene products described
in other biological systems.

Publication Types:
    Review
    Review, Tutorial

PMID: 7779681 [PubMed - indexed for MEDLINE]


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