1: Mol Cell. 2002 Nov;10(5):1119-28. 

ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins
involved in transcriptional regulation.

Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R, Dubois G, Mazo
A, Croce CM, Canaani E.

Kimmel Cancer Center and Department of Microbiology, Jefferson Medical College,
Philadelphia, PA 19107, USA. t_nakamura@mail.jci.tju.edu

ALL-1 is a member of the human trithorax/Polycomb gene family and is also
involved in acute leukemia. ALL-1 is present within a stable, very large
multiprotein supercomplex composed of > or =29 proteins. The majority of the
latter are components of the human transcription complexes TFIID (including
TBP), SWI/SNF, NuRD, hSNF2H, and Sin3A. Other components are involved in RNA
processing or in histone methylation. The complex remodels, acetylates,
deacetylates, and methylates nucleosomes and/or free histones. The complex's
H3-K4 methylation activity is conferred by the ALL-1 SET domain. Chromatin
immunoprecipitations show that ALL-1 and other complex components examined are
bound at the promoter of an active ALL-1-dependent Hox a9 gene. In parallel,
H3-K4 is methylated, and histones H3 and H4 are acetylated at this promoter.

PMID: 12453419 [PubMed - indexed for MEDLINE]


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