1: Thromb Haemost. 1977 Jun 30;37(3):541-8. 

Studies on the tissue thromboplastin during the coagulation-fibrinolytic
process--ultrastructural changes.

Hasegawa H, Nagata H, Murao M.

An electron-microscopical study was made on morphological changes in which T-Tbp
would undergo during clotting and fibrinolytic process. Morphological appearance
of concentrically arranged membrane structure in T-Tbp remained nearly intact
during blood coagulation process. T-Tbp, which existed in the sediments
following dissolution of fibrin clot by the application of UK, showed an
appearance of fine granules adhering to the surface of aggregates of particles
through SEM. Through TEM, T-Tbp in the sediments was found to have retained its
concentrically arranged membrane structures in most places, while, in some other
places the appearance of fused membranes, smaller single vesicles and long
sheets of membranes, and the formation of "blebs" etc. were observed. Various
morphological changes caused by fibrinolytic substances accompanied the loss in
coagulation activities. Our results showed that coagulation activities of T-Tbp
must be completely dependent upon the presence of the membrane structures.

PMID: 578034 [PubMed - indexed for MEDLINE]


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