1: J Parasitol. 2000 Apr;86(2):295-9. 

Interferon- or interleukin-10 production is induced by related Trypanosoma cruzi
antigens.

Cuna WR, Encina JL, Cuna CR.

Department of Tropical Diseases, Instituto Boliviano de Biologia de Altura, La
Paz, Bolivia.

The purpose of this study was to evaluate the effects of a crude Trypanosoma
cruzi antigen (TCA) and its partially purified subfractions TCF1, TCF2 on
peripheral blood mononuclear cells (PBMC) of normal donors and chagasic
patients. TCFI and TCF2 stimulated cells from normal donors and chagasic
patients in association with a significant production of interleukin (IL)-10.
Only PBMC from chagasic patients multiplied after incubation with TCA and
released mainly interferon-y but also IL-10. Neither the production of IL-2 and
IL-4 nor CD4/CD8 ratios were changed after culture with antigens. These data
suggest that some antigens active during the acute phase of T. cruzi infection
would stimulate the production of cytokines that promote progression of
infection, and the immune system can produce a desired cytokine(s) once the
appropriate antigenic stimulus is used.

PMID: 10780548 [PubMed - indexed for MEDLINE]


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