The leukemia-associated AML1 (Runx1)–CBF beta complex functions as a DNA-induced molecular clamp - Full text - MIT Libraries
J Bravo, Z Li, NA Speck, AJ Warren - Nat. Struct. Biol, 2001 - nature.com
... 177) was poorly defined in previous NMR studies because of the lack of NOEs from
this segment to the rest of the ... The leukemia-associated AML1 (Runx1)–CBFβ ...
Cited by 39 - Web Search - nature.com - cs.dartmouth.edu - ncbi.nlm.nih.gov

SLC22A4 and RUNX1: identification of RA susceptible genes - Full text - MIT Libraries
R Yamada, S Tokuhiro, X Chang, K Yamamoto - J Mol Med, 2004 - springerlink.com
... Identification of SLC22A4 and RUNX1 as RA-associated genes Genetics of RA ... The rest
of the genetic contribution seems to be from multiple non-HLA genes. ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Down with mutant GATA 1 - Full text - MIT Libraries
AS Hackam - Clinical Genetics, 2002 - ingentaconnect.com
... lead to altered expression of critical genes (such as RUNX1) that could ... This
lineage-specific developmental ar- rest, in combination with uncontrolled cellular ...
Web Search - ingentaconnect.com

AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34 cells, allowing nerve growth …
JC Mulloy, V Jankovic, M Wunderlich, R Delwel, J … - pnas.org
... ETO (RUNX1-CBFA2T1) [t(8;21)], RUNX1/MDS/EVI1 [t(3;21)], ETV6-RUNX1 [t(12 ... After an
overnight rest in the absence of cytokines, cells were pulsed for 10 min with ...
Web Search - dx.doi.org - dx.doi.org - pnas.org

The Runx 3 transcription factor regulates development and survival of TrkC dorsal root ganglia … - Full text - MIT Libraries
D Levanon, D Bettoun, C Harris-Cerruti, E Woolf, V … - The EMBO Journal, 2002 - embojournal.npgjournals.com
... Runx1 expression is also regulated through IRES-mediated translation control (Pozner
et al ... by uncoordinated gait and abnormal positioning of the legs at rest. ...
Cited by 73 - Web Search - nature.com - emboj.org - md.huji.ac.il - all 8 versions »

Children and adults with acute lymphoblastic leukaemia have similar gene expression profiles. - Full text - MIT Libraries
E Kuchinskaya, M Heyman, D Grander, M Linderholm, … - European Journal Of Haematology, 2005 - blackwell-synergy.com
... 17 Page 18. of samples with ETV6/RUNX1 translocations in this study consisted of
six children and ... different from the rest of the samples (data not shown). ...
Web Search - blackwell-synergy.com - ejh.dk - ncbi.nlm.nih.gov

Mammalian twisted gastrulation is essential for skeleto-lymphogenesis - Full text - MIT Libraries
T Nosaka, S Morita, H Kitamura, H Nakajima, F … - Mol. Cell. Biol, 2003 - mcb.asm.org
... used are as follows: 5'RUNX1, 5'-CCAGCAAGCTGAGGAGCGGCGA-3'; 3'RUNX1, 5'-
CCGACAAACCTGAGGTCGTTGAATCTCG-3 ... of the -/- mice died on the day of birth, the rest ...
Cited by 12 - Web Search - mcb.asm.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Hemogenic and nonhemogenic endothelium can be distinguished by the activity of fetal liver kinase ( … - Full text - MIT Libraries
H Hirai, M Ogawa, N Suzuki, M Yamamoto, G Breier, … - Blood, 2003 - bloodjournal.org
... the dorsal aorta, where hematopoietic clusters were formed, whereas the rest of
the ECs were GFP + . (MN) expressions of the transcripts for Runx1 were shown ...
Cited by 7 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov

Core-binding factor β interacts with Runx 2 and is required for skeletal development - Full text - MIT Libraries
CA Yoshida, T Furuichi, T Fujita, R Fukuyama, N … - Nature Genetics, 2002 - nature.com
... Similarly, the disrupted angiogenesis observed in Runx1 ... directly formed by osteoblasts
in the process of intramembranous ossification, whereas the rest of the ...
Cited by 43 - Web Search - cellbio.wustl.edu - surgeryresearch.com - ncbi.nlm.nih.gov - all 5 versions »

A Serrate-expressing signaling center controls Drosophila hematopoiesis - Full text - MIT Libraries
T Lebestky, SH Jung, U Banerjee - Genes & Development, 2003 - genesdev.org
... Runx1, also known as Acute Myeloid Leukemia 1 (AML1), is essential for the ... of
interesting characteristics that distinguish this region from the rest of the ...
Cited by 18 - Web Search - mcdb.ucla.edu - pubmedcentral.nih.gov - dx.doi.org - all 9 versions »

Gene Expression Profile in AML Gene expression profile reveals deregulation of genes with relevant …
NC Gutierrez, R Lopez-Perez, JM Hernandez, I … - Leukemia, 2005 - nature.com
... different from APL in genes whose expression was variable in the rest of AML ... However,
RUNX1 (at 21q22) expression levels had similar intensity in all AML cases ...
Web Search - nature.com

Histone Deacetylase 3 Interacts with Runx 2 to Repress the Osteocalcin Promoter and Regulate … - Full text - MIT Libraries
TM Schroeder, RA Kahler, X Li, JJ Westendorf - J Biol Chem, 2004 - jbc.org
... GST Pull-down Assays—GST and GST-Runx1 or Runx2 fusion proteins were produced in ...
to focus on its role in regulating Runx2 more closely for the rest of this ...
Cited by 3 - Web Search - jbc.org - ncbi.nlm.nih.gov

Multicolor karyotyping in acute myeloid leukemia
J Tchinda, S Volpert, N McNeil, T NEUMANN, I … - Leuk Lymphoma, 2003 - taylorandfrancis.metapress.com
... In these cases, the copy number gain of the RUNX1 (AML1) gene did not correlate ... AL
11 + 6 + 1 Complex G- Vs SKY: concordant in 3 cases Rest: identification of ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Multicolor Karyotyping in Acute Myeloid Leukemia
J TCHINDA, S VOLPERT, N McNEIL, T NEUMANN, I … - Leukemia & Lymphoma, 2003 - dx.doi.org
... In these cases, the copy number gain of the RUNX1 (AML1) gene did not correlate ... AL
11 + 6 + 1 Complex G- Vs SKY: concordant in 3 cases Rest: identification of ...
Web Search

Functional analysis of RUNX2 mutations in Japanese patients with cleidocranial dysplasia … - Full text - MIT Libraries
T Yoshida, H Kanegane, M Osato, M Yanagida, T … - Am J Hum Genet, 2002 - journals.uchicago.edu
... 2002) and none found in RUNX1. ... but the number and presence of supernumerary teeth
was highly variable and did not correlate with either the rest of the ...
Cited by 13 - Web Search - journals.uchicago.edu - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Gene expression profile reveals deregulation of genes with relevant functions in the different …
S Salamanca-CSIC - Leukemia, 2005 - nature.com
... different from APL in genes whose expression was variable in the rest of AML ... However,
RUNX1 (at 21q22) expression levels had similar intensity in all AML cases ...
Web Search - ncbi.nlm.nih.gov - nature.com - Get it from MIT Libraries

Inherited thrombocytopenias: toward a molecular understanding of disorders of platelet production
AE Geddis, K Kaushansky - Curr Opin Pediatr, 2004 - co-pediatrics.com
... in both mice and humans show that HSCs engineered to express Runx1-Eto exhibit ... At
rest, the discoid shape of the circulating platelet is maintained by a ...
Cited by 2 - Web Search - co-pediatrics.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

BMC Evolutionary Biology - Full text - MIT Libraries
G Glusman, A Kaur, L Hood, L Rowen - BMC Evolutionary Biology, 2004 - biomedcentral.com
... We also studied the relationships between the RUNX1, RUNX2 and RUNX3 orthologs in ...
The first sixteen codons derive from exon 1, the rest of the alignment from ...
View as HTML - Web Search - bmc.ub.uni-potsdam.de - iscid.org

Design principle of gene expression used by human stem cells: implication for pluripotency - Full text - MIT Libraries
S AIMS, P FINDINGS - The FASEB Journal, 2005 - fasebj.org
... and BNC for skin; and BMI1, CD34, TIE, KIT, TAL1 (SCL), and RUNX1 for blood ... The rest
will be down-regulated upon commitment to the cell fate for which they are ...
Cited by 2 - Web Search - dx.doi.org - arxiv.org - adsabs.harvard.edu - all 7 versions »

Decreased transcription of the human FCGR2B gene mediated by the-343 G/C promoter polymorphism and … - Full text - MIT Libraries
MC Blank, RN Stefanescu, E Masuda, F Marti, PD … - Hum Genet, 2005 - springerlink.com
... by the CC promoter compared with the GG promoter under rest- ing conditions (P ... a
SNP affecting the binding of the transcription binding factor RUNX1, located in ...
Web Search - ncbi.nlm.nih.gov

Runx3 is involved in hair shape determination. - Full text - MIT Libraries
E Raveh, S Cohen, D Levanon, Y Groner, U Gat - DEVELOPMENTAL DYNAMICS, 2005 - doi.wiley.com
... Runx1 are expressed in the DP and epidermal compartments of the whiskers ... The DP
expression persists also in the regression (catagen) and rest (telogen) stages ...
Web Search - ncbi.nlm.nih.gov

Analysis of Myelodysplastic Syndromes with Complex Karyotypes by High-Resolution Comparative Genomic …
A Martınrez, M Urioste, L Melchor, D Blesa, L … - GENES, CHROMOSOMES & CANCER, 2005 - doi.wiley.com
... These amplifications were shown by FISH to involve some genes previously described
as amplified in hematological malignancies, such as ERBB2, MLL, and RUNX1. ...
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Quantitative genetic variation: a post-modern view - Full text - MIT Libraries
M Farrall - Human Molecular Genetics, 2004 - hmg.oupjournals.org
... a dozen QTL could explain 25% of the heritability with the rest attributable to ... gene
that modify HIV-1 infection and progression (29) and RUNX1 binding site ...
Cited by 7 - Web Search - hmg.oupjournals.org - eprints.ouls.ox.ac.uk - ncbi.nlm.nih.gov - all 5 versions »

Design Principle of Gene Expression Used by Human Stem Cells; Implication for Pluripotency
R Title - arxiv.org
... TCF3, RUNX1, FLT3, LMO2, SCA1, MEIS1, MPL, TEK, SCA1, MDR1 and others. ... gap were
interpreted as over-expressing the gene and marked as 1. The rest of the ...
View as HTML - Web Search - weizmann.ac.il - weizmann.ac.il

Runx 2 and Runx 3 are essential for chondrocyte maturation, and Runx 2 regulates limb growth through … - Full text - MIT Libraries
CA Yoshida, H Yamamoto, T Fujita, T Furuichi, K … - Genes & Development, 2004 - genesdev.org
... facial bones, and parts of the mandible and clavicle, whereas the rest of the ... The
Runx family consists of three genes, Runx1, Runx2, and Runx3 (Komori 2002 ). ...
Cited by 11 - Web Search - genesdev.org - pubmedcentral.nih.gov - dx.doi.org - all 9 versions »

Mechanisms of BCR–ABL in the pathogenesis of chronic myelogenous leukaemia - Full text - MIT Libraries
R Ren - Nature Reviews Cancer, 2005 - nature.com
... cells,and the interactions of BCR–ABL- expressing cells with the rest of the ... AML1
(also known as RUNX1 and CBFα2),part of which is fused to EVI1 in AME, is ...
Cited by 2 - Web Search - nature.com - ncbi.nlm.nih.gov

Gene expression profiles in the rat streptococcal cell wall-induced arthritis model identified using … - Full text - MIT Libraries
I Rioja, C Clayton, S Graham, P Life, M Dickson - Arthritis Res Ther, 2004 - dx.doi.org
... The rest of the markers exhibited significant fold changes in gene expression ... revealed
high upregulation in runt-related transcription factor 1 (RUNX1) and a ...
Web Search - pubmedcentral.nih.gov - bmc.ub.uni-potsdam.de - arthritis-research.com - all 8 versions »

The Genetic Origins OF Cognition AND Heart Disease IN Down Syndrome
JR Korenberg, G Barlow, LS Salandanan, MD Chen, GE … - doi.wiley.com
... KCNE RUNX1 CBR1 D21S267 ... Adults with DS also have substantially smaller cerebral and
cerebellar hemispheres and hippocampal formations than the rest of the ...
Web Search

Identification and Characterization of Genes Involved in Embryonic Crystal Cell Formation During … - Full text - MIT Libraries
AB Milchanowski, AL Henkenius, M Narayanan, V … - Genetics, 2004 - bruinfly.ucla.edu
... 1998). JAK/ cell number. AML-1, or Runx1, was first isolated as a fusion partner ...
The Engrailed was different from the rest in that it showed wild-type ...
View as HTML - Web Search - dx.doi.org - genetics.org - ncbi.nlm.nih.gov

Increased progenitor proliferation and apoptotic cell death in the sensory lineage of mice …
M Kobayashi, JHLP Ernfors - springerlink.com
... Runx1 is expressed in small-diameter nociceptive neurons, whereas Runx3 is ex- pressed
in ... In the cerebellum and the rest of the brain, N-myc is essential for ...
Web Search

Chromosome Rearrangement Breakpoint Clustering: The Role of Clonal Selection
ON Umanskaya, AA Bystritskiy, SV Razin - MOLECULAR BIOLOGY, 2005 - springerlink.com
... performed in bcr-containing zones [12]; therefore, it is unknown whether these zones
dif- fer from the rest of the ... RUNX1/AML1: A central player in hematopoiesis ...
Web Search - Get it from MIT Libraries

Structural Context of Exons in Protein Domains: Implications for Protein Modelling and Design - Full text - MIT Libraries
B Contreras-Moreira, PF Jonsson, PA Bates - J. Mol. Biol, 2003 - uxmal.cifn.unam.mx
... no different, in terms of their contact profile, com- pared with the rest of the ...
34–195) of signalling protein sonic hedgehog 1eaqa CL1 3 runx1 runt domain ...
View as HTML - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Analysis of the role of AML1-ETO in leukemogenesis, using an inducible transgenic mouse model - Full text - MIT Libraries
KL Rhoades, CJ Hetherington, N Harakawa, DA … - Blood, 2000 - bloodjournal.org
... 1-3 The AML1 gene, also known as RUNX1, encodes a novel transcription factor that
forms ... Total RNA was harvested from the rest of the bone marrow from the double ...
Cited by 83 - Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Novel transcription factors in human CD34 antigen-positive hematopoietic cells - Full text - MIT Libraries
I Gomes, TT Sharma, S Edassery, N Fulton, BG Mar, … - Blood, 2002 - bloodjournal.org
... Hs.129914 RUNX1 Runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 ...
Hs.227630 REST RE1-silencing transcription factor 4q12-q13.3 4.3 L W ...
Cited by 3 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

Cyclin A-dependent Phosphorylation of the ETS-related Protein, MEF, Restricts Its Activity to the G … - Full text - MIT Libraries
Y Miyazaki, P Boccuni, S Mao, J Zhang, H Erdjument … - J Biol Chem, 2001 - intl.jbc.org
... that MEF physically and functionally interacts with members of the AML1/RUNX1 family
of ... dependent fashion, being higher in G 1 than during the rest of the cell ...
Cited by 8 - Web Search - jbc.org - jbc.org - ncbi.nlm.nih.gov

Modeling Human Hematopoietic and Cardiovascular Diseases in Zebrafish
TE North, LI Zon - Key words, 2003 - doi.wiley.com
... cmyb, gata1, gata2, globin, hhex, ikaros, lmo2, pu1, rag1, runx1, scl, and ... number
of erythrocytes is signif- icantly reduced, with maturation ar- rest at the ...
Cited by 5 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov - Get it from MIT Libraries

Differential transcriptional regulation of individual TCR V beta segments before gene rearrangement - Full text - MIT Libraries
F Chen, L Rowen, L Hood, EV Rothenberg - J. Immunol, 2001 - jimmunol.org
... The rest of the cells were used for RNA extraction. ... myeloblastosis transforming gene,
and acute myelogenous leukemia gene-1 (AML1; Runx1) family transcription ...
Cited by 15 - Web Search - jimmunol.org - jimmunol.org - ncbi.nlm.nih.gov - all 5 versions »

Characterization of the malignant melanoma of soft-parts cell line GG-62 by expression analysis … - Full text - MIT Libraries
KL Schaefer, D Wai, C Poremba, E Korsching, F van … - Virchows Archiv, 2002 - springerlink.com
... 4, group A, member 2) and MAD1L1 (yeast mitotic ar- rest deficient homolog-like ... factor
1 Nuclear EN2 Engrailed homolog 2 (transcription/DNA) RUNX1 Runt-related ...
Cited by 8 - Web Search - ncbi.nlm.nih.gov

Update on pediatric systemic lupus erythematosus
D Stichweh, E Arce, V Pascual - Curr Opin Rheumatol, 2004 - co-rheumatology.com
... alterations, however, are reversed when SLE T cells are allowed to rest in vitro
and ... Helms C, Cao L, Krueger JG, et al.: A putative RUNX1 binding site variant ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Issues in Development
MAS MOORE - dx.doi.org
... generate abundant HSC that immediately and rapidly migrate to the YS where they
are detected in abundance, or Runx1 insufficiency blocks ... The rest of the DiI ...
Web Search - liebertonline.com - liebertonline.com

Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesis - Full text - MIT Libraries
CJ Evans, V Hartenstein, U Banerjee - Dev Cell, 2003 - genetics.med.harvard.edu
... Lozenge Specification of CC fate Murine AML-1/Runx1 Required for definitive
hematopoiesis Okuda et al., 1996; Wang et al., 1996a; Lebestky et al., 2000; Fosset ...
Cited by 20 - View as HTML - Web Search - mcdb.ucla.edu - ncbi.nlm.nih.gov - all 4 versions »

Inhibitory Module of Ets-1 Allosterically Regulates DNA Binding through a Dipole-facilitated … - Full text - MIT Libraries
H Wang, LP McIntosh, BJ Graves - J Biol Chem, 2002 - jbc.org
... In the model of the unbound state, helix H1 packs with the rest of the ... binding
cooperativity between Ets-1 and its protein partner CBF 2 (RUNX1) requires the ...
Cited by 6 - Web Search - otter.biochem.ubc.ca - dx.doi.org - ncbi.nlm.nih.gov - all 5 versions »

Analysis of translocations that involve the NUP98 gene in patients with 11p15 chromosomal …
YN Kobzev, J Martinez-Climent, S Lee, J Chen, JD … - GENES, CHROMOSOMES & CANCER, 2004 - doi.wiley.com
... Thus, NUP98, along with MLL, ETV6 (TEL), and RUNX1 (AML1), is one of the rare ... was
seen with hybridization with the other 2 BACs, which spanned the rest of the ...
Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Groucho homologue Grg 5 interacts with the transcription factor Runx 2–Cbfa 1 and modulates its … - Full text - MIT Libraries
W WANG, YG Wang, AM Reginato, DJ Glotzer, N Fukai, … - Developmental Biology, 2004 - stat.nus.edu.sg
... Runx1 is important in hematopoiesis and Runx3 may play a role as a gastrointes-
tinal tumor suppressor and possibly a transcription factor during neurogenesis ...
Cited by 5 - View as HTML - Web Search - ncbi.nlm.nih.gov

Modeling the dosage effect of oncogenes in leukemogenesis
R Ren - Current Opinion in Hematology, 2004 - co-hematology.com
... their susceptible host cells and the interactions of these cells with the rest of
the ... mRNAs, such as c-Myc mRNA [65] and the AML1 (or RUNX1) mRNA transcribed ...
Cited by 4 - Web Search - hmb.utoronto.ca - co-hematology.com - ncbi.nlm.nih.gov - all 5 versions » - Get it from MIT Libraries

The BMP/BMPR/Smad pathway directs expression of the erythroid-specific EKLF and GATA1 transcription … - Full text - MIT Libraries
CA Adelman, S Chattopadhyay, JJ Bieker - Development, 2002 - dev.biologists.org
... in SR1, we generated EBs with this serum substitute for the rest of the ... AML (Runx1)
is a transcription factor that is commonly rearranged in acute myeloid and ...
Cited by 11 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation - Full text - MIT Libraries
I Taniuchi, MJ Sunshine, R Festenstein, DR Littman - Mol. Cell, 2002 - saturn.med.nyu.edu
... Together, these of distinct requirements for trans acting factors for CD4
silencing at different stages of differentiation: Runx1 ...
Cited by 18 - View as HTML - Web Search - ingentaconnect.com - ingentaconnect.com - ncbi.nlm.nih.gov

A survey of the year 2002 literature on applications of isothermal titration calorimetry - Full text - MIT Libraries
MJ Cliff, JE Ladbury - Journal of Molecular Recognition, 2003 - doi.wiley.com
... Architecture of the p40–p47–p67phox complex in the rest- ing state of the ... Altered
affinity of CBF beta-SMMHC for Runx1 explains its role in leukemogenesis. ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Identification and characterization of two types of erythroid progenitors that express GATA-1 at … - Full text - MIT Libraries
N Suzuki, N Suwabe, O Ohneda, N Obara, S Imagawa, … - Ann. NY Acad. Sci, 2005 - bloodjournal.org
Page 1. Suzuki et al . Identification and characterization of two types of
erythroid progenitors that express GATA-1 at distinct levels ...
Cited by 8 - Web Search - dx.doi.org - bloodjournal.org - ncbi.nlm.nih.gov - all 5 versions »

Mouse Embryonic Explant Culture System for Analysis of Hematopoietic and Vascular Development
MH Baron, D Mohn - Methods Mol Med, 2005 - biomed.humanapress.com
... or GFP transgenic or knockin mice could be used as a source of epiblasts to assess
activation of markers of stem/progenitor (eg, Flk1-lacZ or Runx1-lacZ, ref. ...
Cited by 1 - Web Search - journals.humanapress.com - neurosci.humanapress.com - ncbi.nlm.nih.gov - Get it from MIT Libraries