Cooperation between the GATA and RUNX factors Serpent and Lozenge during Drosophila hematopoiesis - Full text - MIT Libraries
L Waltzer, G Ferjoux, L Bataille, M Haenlin - The EMBO Journal, 2003 - embojournal.npgjournals.com
... panel). (D) RUNX1 and GATA1 deleted of its N-terminal domain interact in
vivo. ... (2003) reported that RUNX1 interacts with GATA1. Using ...
Cited by 7 - Web Search - nature.com - emboj.org - pubmedcentral.nih.gov - all 6 versions »

Leukaemia- a developmental perspective - Full text - MIT Libraries
S Izraeli - British Journal of Haematology, 2004 - blackwell-synergy.com
... Gering et al, 2003). Unlike RUNX1 and GATA1, no inherited disorders associated
with germline mutations in SCL have been described. ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov

Down with mutant GATA1 - Full text - MIT Libraries
I Previews - Clinical Genetics, 2002 - blackwell-synergy.com
... factor, RUNX1, which has been associated with similar myeloid malignancies.
Additionally, analysis of two DS-AMKL remission cases did not detect any GATA1 ...
Web Search

A leukemogenic twist for GATA 1 - Full text - MIT Libraries
AT Look - Nature Genetics, 2002 - nature.com
... The resultant RUNX1 fusion proteins contribute to either myeloid or lymphoid acute
leukemia, apparently through ... Somatic GATA1 mutations in AMKL Wechsler et al. ...
Cited by 2 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The BMP/BMPR/Smad pathway directs expression of the erythroid-specific EKLF and GATA1 transcription … - Full text - MIT Libraries
CA Adelman, S Chattopadhyay, JJ Bieker - Development, 2002 - dev.biologists.org
... GATA1 promoters. Also relevant is the ability of Smads to interact with members
of the AML family of transcription factors (Pardali et al., 2000). AML (Runx1) ...
Cited by 11 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

The Runx1 Transcription Factor Inhibits the Differentiation of Naive CD4 T Cells into the Th2 … - Full text - MIT Libraries
O Komine, K Hayashi, W Natsume, T Watanabe, Y Seki … - The Journal of Experimental Medicine - intl.jem.org
... Recently, repressor of GATA (ROG) and friend of GATA1 (FOG1) were shown to bind ... It
must be noted that the expression pattern of Runx1 in the early activation ...
Cited by 13 - Web Search - jem.org - dx.doi.org - ncbi.nlm.nih.gov - all 8 versions »

[CITATION] Disruption of C/EBP {alpha} Function in Acute Myeloid Leukemia
S Froehling, H Doehner
... Mutational inactivation of PU1, GATA1, and C/EBP has been observed in patients with ...
in the gene encoding runt-related transcription factor 1 (RUNX1), has been ...
Web Search - content.nejm.org - ncbi.nlm.nih.gov - Get it from MIT Libraries

Increased dosage of Runx1/AML1 acts as a positive modulator of myeloid leukemogenesis in BXH2 mice - Full text - MIT Libraries
M Yanagida, M Osato, N Yamashita, H Liqun, B Jacob … - Oncogene, 2005 - nature.com
... of RUNX1, which could stimulate cyclin D expression through its interaction with
STAT3. This growth advantage, when partnered with a GATA1 mutation that blocks ...
Web Search - nature.com - ncbi.nlm.nih.gov

Down with mutant GATA 1 - Full text - MIT Libraries
AS Hackam - Clinical Genetics, 2002 - ingentaconnect.com
... factor, RUNX1, which has been as- sociated with similar myeloid malignancies. Ad-
ditionally, analysis of two DS-AMKL remission cases did not detect any GATA1 ...
Web Search - ingentaconnect.com

[CITATION] Disruption of C/EBPa Function in Acute Myeloid Leukemia
S Froehling, H Doehner
Web Search

Acquired mutations in GATA 1 in the megakaryoblastic leukemia of Down syndrome - Full text - MIT Libraries
J Wechsler, M Greene, MA McDevitt, J Anastasi, JE … - Nature Genetics, 2002 - nature.com
... in patients with X-linked macrothrombocytopenia because of a novel GATA1 mutation ...
In vitro analyses of known and novel RUNX1/AML1 mutations in dominant familial ...
Cited by 68 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

The‘definitive’(and‘primitive’) guide to zebrafish hematopoiesis - Full text - MIT Libraries
AJ Davidson, LI Zon - Oncogene, 2004 - nature.com
... vlad tepes gata1 Familial dyserythropoietic anemia and thrombocytopenia ... lmo2 (Thompson
et al., 1998), gata2 (Thompson et al., 1998), runx1 (Kalev-Zylinska et al ...
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Scl is required for dorsal aorta as well as blood formation in zebrafish embryos - Full text - MIT Libraries
LJ Patterson, M Gering, R Patient - Blood, 2005 - bloodjournal.org
... We present evidence that the crucial erythroid, myeloid, and stem cell genes,
gata1, pu.1, and runx1, may be direct targets for Scl. ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Origins of leukaemia in children with Down syndrome - Full text - MIT Libraries
JK Hitzler, A Zipursky - Nature Reviews Cancer, 2005 - nature.com
... 28. Ahmed, M. et al. Natural history of GATA1 mutations in Down Syndrome. ... RUNX1 and
GATA-1 coexpression and cooperation in megakaryocytic differentiation. ...
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AML1-FOG2 fusion protein in myelodysplasia - Full text - MIT Libraries
EM Chan, EM Comer, FC Brown, KE Richkind, ML … - Blood, 2005 - bloodjournal.org
... or point mutation of acute myeloid leukemia 1 (AML1)/RUNX1, which encodes ... AML1 to
most of FOG2, represses the transcriptional activity of both CBF and GATA1. ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

CASE REPORT Large fontanelles are a shared feature of haploinsufficiency of RUNX2 and its co- … - Full text - MIT Libraries
T Goto, M Aramaki, H Yoshihashi, G Nishimura, Y … - Congenital Anomalies, 2004 - blackwell-synergy.com
... Complete loss of Runx1 (Okuda et al. ... 2002), a Gata1 promoter construct that directs
the reporter gene expression to a primitive and definitive erythroid cell ...
Web Search - ingentaconnect.com - ncbi.nlm.nih.gov

GATA 1 mutations in Down Syndrome: Implications for biology and diagnosis of children with transient …
JD Crispino - Pediatric Blood & Cancer, 2005 - doi.wiley.com
... onlyagainstthebackdropoftrisomy21.Bythis model, cells that harbor a GATA1 mutation
disappear ... tional cofactors encoded by chromosome 21, such as RUNX1 and ETS2. ...
Cited by 2 - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Core-binding factor β interacts with Runx 2 and is required for skeletal development - Full text - MIT Libraries
CA Yoshida, T Furuichi, T Fujita, R Fukuyama, N … - Nature Genetics, 2002 - nature.com
... Both RUNX1 and CBFβ are essential for hematopoiesis 2–6 . Haploinsufficiency of
another runt ... of Cbfb –/– mice by introducing Cbfb using the Gata1 promoter ...
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Report on the ‘Expert Workshop on the Biology of Chromosome 21: towards gene-phenotype … - Full text - MIT Libraries
K Gardiner, MT Davisson, M Pritchard, D Patterson, … - Cytogenetic and Genome Research, 2005 - content.karger.com
... in mice with hypo- morphic or dominant negative Runx1 or Cbfb alleles. Shai Israeli
(Sheba Medical School, Tel Aviv) described acquired mutations in GATA1, an X ...
Web Search - dx.doi.org - karger.com - ncbi.nlm.nih.gov - all 5 versions »

Requisite roles of Runx2 and Cbfb in skeletal development - Full text - MIT Libraries
T Komori - J Bone Miner Metab, 2003 - springerlink.com
... the following roles of these genes in different cell lineages: Runx1 is essential ...
generated Cbfb transgenic mice under the control of the Gata1 promoter, which ...
Cited by 4 - Web Search - springerlink.com - ncbi.nlm.nih.gov

The core-binding factor bold beta subunit is required for bone formation and hematopoietic … - Full text - MIT Libraries
J Miller, A Horner, T Stacy, C Lowrey, JB Lian, G … - Nature Genetics, 2002 - nature.com
... ratio, and, conversely, that overexpression of a functional Runx1 protein selectively ...
megakaryocyte, eosinophil and mast cell–restricted Gata1 promoter to ...
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Runx 3 is required for hematopoietic development in zebrafish - Full text - MIT Libraries
ML Kalev-Zylinska, JA Horsfield, MVC Flores, JH … - Developmental Dynamics, 2003 - doi.wiley.com
... through forced transient expression of runx3 but in contrast to runx1 (Kalev-Zylinska ...
Early Expression of scl, lmo2, and gata1 Is Preserved in runx3-Morpholino ...
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Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants - Full text - MIT Libraries
D Traver, BH Paw, KD Poss, WT Penberthy, S Lin, LI … - Nature Immunology, 2003 - nature.com
... blood and vessel development and expression of a human RUNX1-CBF2T1 transgene ... A nonsense
mutation in zebrafish gata1 causes the bloodless phenotype in vlad ...
Cited by 14 - Web Search - zfblasta.tch.harvard.edu - eanimal.snu.ac.kr - ncbi.nlm.nih.gov - all 6 versions »

The core-binding factor β subunit is required for bone formation and hematopoietic maturation - Full text - MIT Libraries
J Miller, A Horner, T Stacy, C Lowrey, JB Lian, G … - Nature Genetics, 2002 - nature.com
... and, con- versely, that overexpression of a functional Runx1 protein selec ... the erythroid,
megakaryocyte, eosinophil and mast cell–restricted Gata1 promoter to ...
Cited by 25 - Web Search - cancer.dartmouth.edu - cancer.dartmouth.edu - ncbi.nlm.nih.gov - all 5 versions »

Molecular Mechanisms of Megakaryocyte Differentiation - Full text - MIT Libraries
H Schulze, RA Shivdasani - Seminars in Thrombosis and Hemostasis, 2004 - thieme-connect.com
... 986 12 Hitzler JK, Cheung J, Li Y, Scherer SW, Zipursky A. GATA1 mutations in ... RUNX1
and GATA-1 coexpression and cooperation in megakaryocytic differentiation. ...
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Functional conservation of hematopoietic factors in Drosophila and vertebrates - Full text - MIT Libraries
N Fossett, RA Schulz, JJ Sanz-Ezquerro, C Tickle, … - Differentiation, 2001 - blackwell-synergy.com
... The mammalian family members include Runx1, Runx2, and Runx3 (Westendorf and Hiebert,
1999). ... Runx1 hematopoietic function involves dimerization with CBF . ...
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Non-cell autonomous requirement for the bloodless gene in primitive hematopoiesis of zebrafish - Full text - MIT Libraries
EC Liao, NS Trede, D Ransom, A Zapata, M Kieran, … - Development, 2002 - dev.biologists.org
... of both primitive and definitive hematopoiesis such as Scl, Lmo2, Gata1, Gata2 and ...
hematopoiesis, such as Myb, Kit, Slf (Pou3f4), Tel, Aml1 (Runx1), Cbfb and ...
Cited by 12 - Web Search - dev.biologists.org - ncbi.nlm.nih.gov

CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid … - Full text - MIT Libraries
GA Blobel, T Nakajima, R Eckner, M Montminy, SH … - Biochemistry, 1998 - dx.doi.org
... BM Weinstein, PP Liu, and M. Yamamoto Self-Association of Gata1 Enhances
Transcriptional ... M. Mogass, R. Khetawat, LL Delehanty, and AN Goldfarb RUNX1 and GATA- ...
Cited by 136 - Web Search - pnas.org - pubmedcentral.nih.gov - surrey.ac.uk - all 7 versions »

Inherited thrombocytopenias: toward a molecular understanding of disorders of platelet production
AE Geddis, K Kaushansky - Curr Opin Pediatr, 2004 - co-pediatrics.com
... in both mice and humans show that HSCs engineered to express Runx1-Eto exhibit ... of
severe anemia [65], a megakaryocyte-specific deletion of Gata1 that maintains ...
Cited by 2 - Web Search - co-pediatrics.com - ncbi.nlm.nih.gov - Get it from MIT Libraries

Mutations of the PU. 1 Ets domain are specifically associated with murine radiation-induced, but not … - Full text - MIT Libraries
N Suraweera, E Meijne, J Moody, LG Carvajal- … - Oncogene, 2005 - nature.com
... proteins including GATA1 binding protein 1 (GATA1), CCAAT/enhancer binding protein
beta (CEBPB), and other myeloid regulators such as c-jun and RUNX1/AML-1 ...
Cited by 1 - Web Search - nature.com - ncbi.nlm.nih.gov

Oncogenes et leucemies: historique et perspectives
S Gisselbrecht, BG Roussy - M e decine et Science, 2003 - erudit.org
... du CBF (core binding factor) qui comporte deux sous-unités CBFA2 (ou AML1, RUNX1)
et CBFβ ... Ces leucémies présentent des mutations ponctuelles du gène GATA1. ...
Cited by 2 - Cached - Web Search

Tel/Etv 6 is an essential and selective regulator of adult hematopoietic stem cell survival - Full text - MIT Libraries
H Hock, E Meade, S Medeiros, JW Schindler, PJM … - Genes & Development, 2004 - genesdev.org
... 2003 ), Aml1/runx1 (Ichikawa et al. ... committed lineages by using lineage-specific
promoters; that is, CD19-Cre: B lineage; Lck-Cre: T cells; Gata1-Cre: erythroid ...
Cited by 1 - Web Search - genesdev.org - pubmedcentral.nih.gov - ncbi.nlm.nih.gov

Regulation of skeletal development by the Runx family of transcription factors - Full text - MIT Libraries
T Komori - Journal of Cellular Biochemistry, 2005 - doi.wiley.com
... Specific transloca- tions in the Runx1 and Cbfb genes are involved in ... mice by
introducing Cbfb using the Gata1 promoter, which directs transgene expression to ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

Oligo GEArray® Human Hematopoietic Stem Cells and Hematopoiesis Microarray
S Conditions - search.cosmobio.co.jp
... BCL11A, CBFB, CD80, CD86, CEBPE, CEBPG, EGR1, ETS1, ETV6, GATA1, GATA2, GFI1 ... MYC,
NCOA6, NFYA, NOTCH1, NOTCH2, NOTCH4, PAX5, RBPSUH, RHOH, RUNX1, SCAND1, STAT1 ...
View as HTML - Web Search

Development of a human acute myeloid leukaemia screening panel and consequent identification of …
ML Smith, R Arch, LL Smith, N Bainton, M Neat, C … - ingentaconnect.com
... mutations identified in three of the tested genes FLT3-CEBPA-NRAS and FLT3-RUNX1-
CEBPA ... H., Haas, OA & Izraeli, S. (2003) Mutations in exon 2 of GATA1 are early ...
Web Search

Progress in Hematology
AB Cantor - Int J Hematol, 2005 - cardenjennings.metapress.com
... Natural history of GATA1 mutations in Down syndrome. Blood. ... RUNX1 and GATA-1
coexpression and coopera- tion in megakaryocytic differentiation. Blood. ...
Web Search

Hematopoietic perturbation in zebrafish expressing a tel-jak2a fusion.
SM Onnebo, MM Condron, DO McPhee, GJ Lieschke, AC … - Experimental Hematology, 2005 - eanimal.snu.ac.kr
... tel-jak2a (D,F,H), were analyzed for expression of gata1 at 24 ... Transient ubiquitous
overexpression in zebra- fish of human RUNX1-CBF2T1, the oncogenic product ...
View as HTML - Web Search - ncbi.nlm.nih.gov - Get it from MIT Libraries

Disruption of differentiation in human cancer: AML shows the way - Full text - MIT Libraries
DG Tenen - Nature Reviews Cancer, 2003 - nature.com
... 15. Huang, G. et al. Dimerization with PEBP2 protects RUNX1/AML1 from
ubiquitin-proteasome-mediated degradation. EMBO J. 20, 723-733 (2001). ...
Cited by 66 - Web Search - nature.com - ncbi.nlm.nih.gov - ncbi.nlm.nih.gov

Research Paper Development of a human acute myeloid leukaemia screening panel and consequent … - Full text - MIT Libraries
ML Smith, R Arch, LL Smith, N Bainton, M Neat, C … - British Journal of Haematology, 2005 - blackwell-synergy.com
... Analysis was performed on six genes known to be mutated in AML (RUNX1, FLT3, KIT,
CEBPA, PTPN11 and NRAS) and an additional two candidate genes (CCND3 and FES ...
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research paper Microarray transcript profiling distinguishes the transient from the acute type of … - Full text - MIT Libraries
S McElwaine, C Mulligan, J Groet, M Spinelli, A … - British Journal of Haematology, 2004 - blackwell-synergy.com
... include the abolition of GATA1-mediated cell cycle arrest via CDKN2C. From the
chromosome 21 genes shown in Fig 4B we decided to verify RUNX1 further because ...
Web Search

Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem … - Full text - MIT Libraries
S Gerecht-Nir, JE Dazard, M Golan-Mashiach, S … - Developmental Dynamics, 2005 - doi.wiley.com
... 4 LMO2 LIM domain only 2 5 TIE Tyrosine kinase 6 GATA1 GATA binding protein 1 7
RUNX1 Runt-related transcription factor 1 8 216966 at CD41(Gpllb) 9 PTPRC CD45 ...
Cited by 2 - Web Search - weizmann.ac.il - weizmann.ac.il - ncbi.nlm.nih.gov

Absence of Yolk sac Hematopoiesis from Mice with a Targeted Disruption of the scl Gene - Full text - MIT Libraries
L Robb, I Lyons, R Li, L Hartley, F Kontgen, RP … - Proceedings of the National Academy of Sciences - pnas.org
... which differentiate into endothelial cells in the absence of Gata1 Development,
December 22 ... L. Carlsson, N. Speck, J. Palis, and G. Keller Runx1 is essential ...
Cited by 181 - Web Search - pubmedcentral.nih.gov - ncbi.nlm.nih.gov - adsabs.harvard.edu

The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, … - Full text - MIT Libraries
MA Hall, DJ Curtis, D Metcalf, AG Elefanty, K … - Blood, 2004 - dx.doi.org
... IR Williams, NA Speck, and DG Gilliland Loss of Runx1 perturbs adult ... which differentiate
into endothelial cells in the absence of Gata1 Development, December 22 ...
Cited by 21 - Web Search - pnas.org - intl.pnas.org - pubmedcentral.nih.gov - all 7 versions »

Mutant-specific gene programs in the zebrafish - Full text - MIT Libraries
GJ Weber, SE Choe, KA Dooley, NN Paffett-Lugassy, … - Blood, 2005 - bloodjournal.org
... blood and vessel development and expression of a human RUNX1-CBF2T1 transgene ... A nonsense
mutation in zebrafish gata1 causes the bloodless phenotype in vlad ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov

Histone Deacetylase 3 Interacts with Runx 2 to Repress the Osteocalcin Promoter and Regulate … - Full text - MIT Libraries
TM Schroeder, RA Kahler, X Li, JJ Westendorf - J Biol Chem, 2004 - jbc.org
... It associates with several transcription factors, including GATA1, peroxisome
proliferator-activated ... GST Pull-down Assays—GST and GST-Runx1 or Runx2 fusion ...
Cited by 3 - Web Search - jbc.org - ncbi.nlm.nih.gov

Microarray transcript profiling distinguishes the transient from the acute type of megakaryoblastic … - Full text - MIT Libraries
S McElwaine, C Mulligan, J Groet, M Spinelli, A … - British Journal of Haematology, 2004 - ingentaconnect.com
... The TMD and AMKL blasts are morphologically and immuno-phenotypically identical,
and have the same acquired mutations in GATA1. ... RNA utiliz ation GATA1 exon 2 ...
Cited by 1 - Web Search - ncbi.nlm.nih.gov

acquises de la cellule souche hematopoietique ou d’un precurseur deja commis vers les lignees …
S YNTHESE - MEDECINE/SCIENCES, 2003 - ist.inserm.fr
... du CBF (core binding factor) qui comporte deux sous-unités CBFA2 (ou AML1, RUNX1)
et CBFβ ... Ces leucémies présentent des mutations ponctuelles du gène GATA1. ...
View as HTML - Web Search - erudit.org

Novel transcription factors in human CD34 antigen-positive hematopoietic cells - Full text - MIT Libraries
I Gomes, TT Sharma, S Edassery, N Fulton, BG Mar, … - Blood, 2002 - bloodjournal.org
... 6 whereas GATA1 and GATA2 are down-regulated. ... Hs.129914 RUNX1 Runt-related transcription
factor 1 (acute myeloid leukemia 1; aml1 oncogene) 21q22.3 13.6 I W ...
Cited by 3 - Web Search - bloodjournal.org - dx.doi.org - ncbi.nlm.nih.gov - all 7 versions »

The Molecular Basis of Leukemia - Full text - MIT Libraries
DG Gilliland, CT Jordan, CA Felix, CT Jordan - Hematology, 2004 - asheducationbook.org
... When mutations such as RUNX1-ETO are expressed alone, they impair differentiation
and ... with Down syndrome is associated with mutations in the GATA1 gene that ...
Cited by 1 - Web Search - neuroscienzemolecolari.it - asheducationbook.org - ncbi.nlm.nih.gov

The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial … - Full text - MIT Libraries
A Kubo, V Chen, M Kennedy, E Zahradka, GQ Daley, G … - Blood, 2005 - bloodjournal.org
... While Scl and Runx1 play central roles in the establishment of the hematopoietic ...
Molecular analysis revealed comparable levels of T 38 and Gata1 39 expression ...
Web Search - bloodjournal.org - ncbi.nlm.nih.gov