1: Development. 2001 Sep;128(17):3307-19. 

Headless flies generated by developmental pathway interference.

Jiao R, Daube M, Duan H, Zou Y, Frei E, Noll M.

Institute for Molecular Biology, University of Zurich, Winterthurerstr. 190,
CH-8057 Zurich, Switzerland.

Ectopic expression of transcription factors in eye-antennal discs of Drosophila
strongly interferes with their developmental program. Early ectopic expression
in embryonic discs interferes with the developmental pathway primed by Eyeless
and generates headless flies, which suggests that Eyeless is necessary for
initiating cell proliferation and development of both the eye and antennal disc.
Interference occurs through a block in the cell cycle that for some ectopic
transcription factors is overcome by D-CycE or D-Myc. Late ectopic expression in
cone cell precursors interferes with their differentiation. We propose that this
developmental pathway interference is a general surveillance mechanism that
eliminates most aberrations in the genetic program during development and
evolution, and thus seriously restricts the pathways that evolution may take.

PMID: 11546747 [PubMed - indexed for MEDLINE]


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2: Mol Genet Metab. 2000 Sep-Oct;71(1-2):391-6. 

Kidney development: regulatory molecules crucial to both mice and men.

Bates CM.

Children's Research Institute, Children's Hospital, Columbus, Ohio 43205, USA.
batesc@pediatrics.ohio-state.edu

Although the study of embryonic kidney development began in the 1950s, three
decades passed until scientists began identifying the molecular controls of
renal organogenesis. Most of these advances have come from mouse gene targeting
and rodent kidney explant manipulation. Translation of the rodent data to human
congenital kidney disease has only just begun. The activities of those
regulatory molecules proven to be used in common appear remarkably similar in
mouse and human renal development. Examples of these genes include glial cell
line-derived neurotrophic factor (GDNF), RET, PAX2, Wilms tumor suppressor
(WT1), and components in the renin-angiotensin pathway. Other factors that
participate in mouse renal organogenesis, such as N-Myc, may later be proven
important in human kidney development. Copyright 2000 Academic Press.

Publication Types:
    Review
    Review, Tutorial

PMID: 11001832 [PubMed - indexed for MEDLINE]


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