Chapter 4: Decoding early visual representations from fMRI ensemble responses

Yukiyasu Kamitani
ATR Computational Neuroscience Laboratories

Despite the wide-spread use of human neuroimaging, its potential to read out perceptual contents has not been fully explored. Mounting evidence from animal neurophysiology has revealed the roles of the early visual cortex in representing visual features such as orientation and motion direction. However, non-invasive neuroimaging methods have been thought to lack the resolution to probe into these putative feature representations in the human brain. In this chapter, we present methods for fMRI decoding of early visual representations, which find the mapping from fMRI ensemble responses to visual features using machine learning algorithms. First, we show how early visual features represented in 'sub-voxel' neural structures could be predicted, or decoded, from ensemble fMRI responses. Second, we discuss how multi-voxel patterns could represent more information than the sum of individual voxels, and how an effective set of voxels can be selected from all available voxels that leads to robust decoding. Third, we demonstrate a modular decoding approach in which a novel stimulus, not used for the training of the decoding algorithm, can be predicted by combining the outputs of multiple modular decoders. Finally, we discuss a method for neural mind-reading, which attempts to predict a person's subjective state using a decoder trained with unambiguous stimulus presentation.

Key words: neural decoding, multi-voxel pattern, machine learning, ensemble feature selectivity, sparse representation, voxel correlation, modular decoding, visual image reconstruction, neural mind-reading

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